P16ink4a Expression
Mostrando 1-12 de 89 artigos, teses e dissertações.
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1. Association between HPV infection and prostate cancer in a Mexican population
Abstract The aim of this study was to evaluate the association between prostate cancer (PCa) and Human papillomavirus (HPV) infection in the Mexican population. We studied 356 paraffin-embedded tissues from unrelated Mexican men with PCa or benign prostatic hyperplasia (BPH), with the latter serving as control. HPV detection was performed by polymerase chain
Genet. Mol. Biol.. Publicado em: 29/11/2018
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2. Knockout of p16INK4a promotes aggregative growth of dermal papilla cells
Summary Objective: Dermal papilla cells (DPCs) are located in the hair follicles and play an important role in hair growth. These cells have the ability to induce hair follicle formation when they display aggregative behavior. DPCs derived from the androgenetic alopecia (AGA) area undergo premature senescence in vitro, associated with p16INK4a expression. T
Rev. Assoc. Med. Bras.. Publicado em: 2017-10
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3. A phthalide derivative isolated from endophytic fungiPestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells
MP [4-(3′,3′-dimethylallyloxy)-5-methyl-6-methoxyphthalide] was obtained from liquid culture of Pestalotiopsis photiniaeisolated from the Chinese Podocarpaceae plant Podocarpus macrophyllus. MP significantly inhibited the proliferation of HeLa tumor cell lines. After treatment with MP, characteristic apoptotic features such as DNA fragmentation and chrom
Braz J Med Biol Res. Publicado em: 30/07/2013
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4. p16 (INK4a) has clinicopathological and prognostic impact on oropharynx and larynx squamous cell carcinoma
CDKN2A encodes proteins such as p16 (INK4a), which negatively regulate the cell-cycle. Molecular genetic studies have revealed that deletions in CDKN2A occur frequently in cancer. Although p16 (INK4a) may be involved in tumor progression, the clinical impact and prognostic implications in head and neck squamous cell carcinoma (HNSCC) are controversial. The o
Braz J Med Biol Res. Publicado em: 2012-12
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5. An evaluation of p16INK4a expression in cervical intraepithelial neoplasia specimens, including women with HIV-1
Although several studies have evaluated the role of p16INK4a as a diagnostic marker of cervical intraepithelial neoplasia (CIN) and its association with disease progression, studies regarding the role of p16INK4a in human immunodeficiency virus (HIV)-infected patients remain scarce. The present study was designed to determine the potential utility of p16INK4
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-08
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6. Testosterone therapy delays cardiomyocyte aging via an androgen receptor-independent pathway
The testicular feminized (Tfm) mouse carries a nonfunctional androgen receptor (AR) and reduced circulating testosterone levels. We used Tfm and castrated mice to determine whether testosterone modulates markers of aging in cardiomyocytes via its classic AR-dependent pathway or conversion to estradiol. Male littermates and Tfm mice were divided into 6 experi
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-11
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7. Chlamydia trachomatis and human papillomavirus coinfection: association with p16INK4a and Ki67 expression in biopsies of patients with pre-neoplastic and neoplastic lesions
The objective of this study was to identify the frequency of coinfection by human papillomavirus (HPV) and Chlamydia trachomatis (CT) in cervical lesions and relate it with immunohistochemical expression of p16INK4a and Ki67, both oncogenicity markers. A cross-sectional study with 86 women from primary care units in southern Brazil was conducted. Cervical sw
Brazilian Journal of Infectious Diseases. Publicado em: 2011-04
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8. Immunohistochemical expression of p53, p16 and hTERT in oral squamous cell carcinoma and potentially malignant disorders
Oral carcinogenesis is a multi-step process. One possible step is the development of potentially malignant disorders known as leukoplakia and erytroplakia. The objective of this study was to use immunohistochemistry to analyze the patterns of expression of the cell-cycle regulatory proteins p53 and p16INK4a in potentially malignant disorders (PMD) of the ora
Brazilian Oral Research. Publicado em: 2011-02
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9. Análise de polimorfismos e de expressão do gene p16INK4a em neoplasias cervicais / Analysis of polymorphisms and expression of the p16INK4a gene in cervical neoplasms
O câncer de colo do útero é o segundo carcinoma mais frequente em mulheres no mundo e um dos cânceres femininos mais incidentes no Brasil. Em lesões pré-malignas e malignas do colo uterino, a proteína p16INK4a, que participa do controle do ciclo celular, apresenta um aumento considerável de sua expressão, devido possivelmente à presença de oncopro
Publicado em: 2011
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10. Expressão de p53, p16ink4a, p21Waf1/cip1, p21Ras e p27Kip1/cip1 em pacientes com adenocarcinoma gástrico com invasão da submucosa submetidos a gastrectomia com linfadenectomia D2 / Expression of p53, p16ink4a, p21Waf1/cip1, p21Ras, and p27Kip1/cip1 in patients exhibiting gastric adenocarcinoma with submucosa invasion submitted to gastrectomy with D2 linfadenectomy
INTRODUCTION: Early gastric cancer that invades the submucosa might have a lymphonodal involvement in about 20% of the cases. Gastrectomy and D2 linfadenectomy is a procedure that has presented mortality and morbidity. Determining which patients would have a greater risk of lymphonodal involvement would allow treatments with fewer complications. Recently, se
Publicado em: 2010
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11. Expressão da p16INK4 em lesões precursoras de baixo grau do carcinoma escamoso do colo uterino : estudo prospectivo de seguimento
The squamous carcinoma of the cervix uterine is one of the neoplasias of bigger incidence in the whole world, also in Brazil, being responsible for the death of thousand of women to each year, great part of them occurring in full productive age. Throughout last the fifty years, diverse researchers have studied this neoplasia. We know that the invading phase
Publicado em: 2010
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12. GTPases Rho e o potencial regenerativo da retina de mamíferos / Rho GTPases and the regenerative potential of the mammalian retina
Ciliary Body (CB) is a potential source of stem cells in the adult retina, but its activation is still unknown. Rho GTPases play a role in actin-based cytoskeleton reorganization, regulate signaling pathways and gene transcription, cell survival and cell proliferation. In this study we investigated the expression of Rho GTPases in CB cells and their role on
Publicado em: 2010