Oxygen And Glucose Deprivation Ogd
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Participação das vias de estresse oxidativo na neuroproteção mediada pelo treinamento físico em fatias cerebrais submetidas à privação de oxigênio e glicose
Ischemia leads to a variety of pathological events, including excitotoxicity, inflammation, delayed neuronal dysfunction and cell death through hyperactivation of glutamate receptors and production of free radicals, such as nitric oxide (NO). The mechanism by which cerebral excess formation of NO, which mediates neuronal death involving energy depletion, lip
Publicado em: 2011
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2. Avaliação de parâmetros neuroquímicos em fatias de hipocampo de rato submetidas à privação de oxigênio e glicose
Mesmo a isquemia sendo a terceira causa de morte em países industrializados, os mecanismos relacionados a esta doença ainda continuam polêmicos e obscuros. Utilizou-se a técnica de privação de oxigênio e glicose (OGD) em fatias do hipocampo de rato para investigar parâmetros mitocondriais, neurais, astrogliais e metabólicos no período de isquemia e
Publicado em: 2010
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3. Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors
Hypoxic–ischemic brain injury in premature infants results in cerebral white matter lesions with prominent oligodendroglial injury and loss, a disorder termed periventricular leukomalacia (PVL). We have previously shown that glutamate receptors mediate hypoxic–ischemic injury to oligodendroglial precursor cells (OPCs) in a model of PVL in the develop
National Academy of Sciences.
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4. Requirement for nitric oxide activation of p21ras/extracellular regulated kinase in neuronal ischemic preconditioning
The mechanisms underlying neuronal ischemic preconditioning, a phenomenon in which brief episodes of ischemia protect against the lethal effects of subsequent periods of prolonged ischemia, are poorly understood. Ischemia can be modeled in vitro by oxygen-glucose deprivation (OGD). We report here that OGD preconditioning induces p21ras (Ras) activation in an
The National Academy of Sciences.
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5. mTOR/S6 Kinase Pathway Contributes to Astrocyte Survival during Ischemia*
Neurons are highly dependent on astrocyte survival during brain damage. To identify genes involved in astrocyte function during ischemia, we performed mRNA differential display in astrocytes after oxygen and glucose deprivation (OGD). We detected a robust down-regulation of S6 kinase 1 (S6K1) mRNA that was accompanied by a sharp decrease in protein levels an
American Society for Biochemistry and Molecular Biology.
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6. Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice
To investigate the role of brain angiotensin II (ANG II) in the pathogenesis of injury following ischemic stroke, mice overexpressing renin and angiotensinogen (R+A+) and their wild-type control animals (R−A−) were used for experimental ischemia studies. Focal brain ischemia was induced by middle cerebral artery occlusion (MCAO). The severity of ischemic
American Physiological Society.