Oral Epithelial Dysplasia Immunohistochemistry
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Atividade gelatinolítica in situ e imuno-expressão das metaloproteinases 2 e 9 em lesões potencialmente malignas e carcinomas espinocelulares bucais / In situ gelatinolytic activity and immunoexpression of metalloproteinases 2 and 9 in oral potentially malignant lesions and squamous cell carcinomas
The transition from normal oral mucosa to invasive carcinoma has a complex and multifactorial etiology. Oral leukoplakia (OL) is regarded as the most prevalent potentially malignant oral lesion, with a higher tendency for malignant transformation if compared to normal oral mucosa. Although an increased activity of matrix metalloproteinases (MMPs) 2 and 9 in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
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2. Immunohistochemical expression of p53, p16 and hTERT in oral squamous cell carcinoma and potentially malignant disorders
Oral carcinogenesis is a multi-step process. One possible step is the development of potentially malignant disorders known as leukoplakia and erytroplakia. The objective of this study was to use immunohistochemistry to analyze the patterns of expression of the cell-cycle regulatory proteins p53 and p16INK4a in potentially malignant disorders (PMD) of the ora
Brazilian Oral Research. Publicado em: 2011-02
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3. Leucoplasias bucais: estudo comparativo entre o grau histológico de displasia, imunoexpressão de hMLH1 e p53 e análise quantitativa de AgNOR
hMLH1 is a protein of the mammalian mismatch repair system (MMR), which maintains genomic stability during repeated duplication. Investigations point to a role of hMLH1 in oral carcinogenesis, and its expression pattern may be related to epigenetic events and microsatellite instability in oral leukoplakias and squamous cell carcinomas. It seems that those al
Publicado em: 2010
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4. Leucoplasia oral: tratamento cirúrgico com laser de CO2 e de diodo e análise por imuno-histoquímica da expressão de proteínas relacionadas à carcinogênese (p53, COX-2 e EGFR) / Oral leukoplakia: surgical treatment with CO2 and diode lasers and analysis of the expression of proteins related to carcinogenesis (p53, COX-2 e EGFR) by immunohistochemistry
Oral leukoplakia (OL) is a potentially malignant lesion, defined as a white patch that cannot be characterized as any other disease of the oral mucosa. In general, OL should be treated; however no treatment available has been able to prevent malignant transformation. The aim of this study was to evaluate the efficacy of surgical treatment with CO2 and diode
Publicado em: 2010
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5. Comparação imunoistoquímica das expressões das proteínas p27 e c-jun na carcinogênese intra-oral / Immunohistochemical comparison between the p27 and c-jun proteins expression in the oral carcinogenesis
The expression of many cell cycle proteins has been studied in a number of malignant lesions. Among the main ones is the p27, which is encoded by the same name tumor suppressor gene, and it is altered in carcinomas, including oral cancers. Another protein that plays a role in the cell cycle control is the c-jun, which is encoded by a proto-oncogene, and acts
Publicado em: 2009
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6. Expressão da acido graxo sintase, ErbB-2, p27 E Skp2 na carinogenese bucal induzida por 1-oxido 4-nitroquinolina em camundongos e efeito antitumoral do Orlistat / Fatty Acid Sintase, ErbB-2, p27 E Skp2 expression in oral carcinogenesis induced by 4-nitroquinoline 1-oxide and antitumoral Orlistat effects
Squamous cell carcinoma of the oral cavity is one of the most common malignant epithelial neoplasms, and a better understanding of its molecular pathways could help the development of new treatment or preventive agents. Several proteins such as Fatty Acid Synthase (FAS), ErbB-2, p27 and Skp2 are involved in the tumorigenesis process. FAS has an enzyme with m
Publicado em: 2007
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7. Expressão imuno-histoquímica das integrinas α2ß1, α3ß1, e α5ß1, em mucosa oral normal, hiperplasia fibroepitelial inflamatória oral e displasia epitelial oral
The objective of this study was perform by the streptoavidin-biotin technique an immunohistochemical analysis of α2β1, α3β1e α5β1 integrins in 11 normal oral mucosa (NOM), 16 oral inflammatory fibroepithelial hyperplasia (OIFH) and 25 oral epithelial dysplasia (OED) (16 mild, 2 moderates and 7 severe), to determine if exists qua
Publicado em: 2006
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8. "Estudo da expressão da p16 em casos de líquen plano bucal" / p16 immunoexpression in oral lichen planus
We realized immunohistochemical procedures with p16 and Ki-67 in lesions of oral lichen planus to verify the presence and kind of its immunoexpression amog the two groups of patients, asymptomatic and symptomatic, correlating the clinical and histopathological diagnosis with the immunohistochemical data in order to verify if oral lichen planus can be conside
Publicado em: 2006
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9. Estudo imunohistoquimico das citoqueratinas, do indice de proliferação celular e da resposta inflamatoria na paracoccidioidomicose bucal
Paracoccidioidomycosis (Pmycosis) is a common systemic mycosis in Latin America, with variable clinical presentation. The chronic form frequently involves the oral mucosa, showing multiple moriform like lesions. Microscopically, oral Pmycosis is cha_acterized by pseudoepitheliomatous hyperplasia (PEH), and granulomatous inflammatory response, besides polimor
Publicado em: 2004
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10. Skp2 is oncogenic and overexpressed in human cancers
Skp2 is a member of the F-box family of substrate-recognition subunits of SCF ubiquitin–protein ligase complexes that has been implicated in the ubiquitin-mediated degradation of several key regulators of mammalian G1 progression, including the cyclin-dependent kinase inhibitor p27, a dosage-dependent tumor suppressor protein. In this study, we examin
The National Academy of Sciences.