Optimizing Behavior
Mostrando 25-27 de 27 artigos, teses e dissertações.
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25. Pressão arterial e manipulação tubular renal de sodio em um modelo de septicemia em ratos
Acute renal failure is a frequent complication in septic patients associated with a high mortality rate. An important characteristic is a decrease in glomerular filtration rate, which is even present in situations where renal blood flow has been maintained. Prevailing hypothesis on the pathogenesis of renal failure suggest an inappropriate and uncontrolled r
Publicado em: 2001
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26. Pleiotropic Overdominance and the Maintenance of Genetic Variation in Polygenic Characters
A model of selection is described in which optimizing phenotypic selection is combined with pleiotropic overdominance. Thus, the role that mutation commonly plays in models of phenotypic evolution is replaced by balancing selection. Expressions are provided for the equilibrium genetic variance in phenotype and for the heterozygosity. An approximate analysis
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27. Mutational Analysis Suggests That Activation of the Yeast Pheromone Response Mitogen-activated Protein Kinase Pathway Involves Conformational Changes in the Ste5 Scaffold Protein
Ste5 is essential for pheromone response and binds components of a mitogen-activated protein kinase (MAPK) cascade: Ste11 (MEKK), Ste7 (MEK), and Fus3 (MAPK). Pheromone stimulation releases Gβγ (Ste4-Ste18), which recruits Ste5 and Ste20 (p21-activated kinase) to the plasma membrane, activating the MAPK cascade. A RING-H2 domain in Ste5 (residues 177�
The American Society for Cell Biology.