One Trial Tolerance
Mostrando 13-24 de 32 artigos, teses e dissertações.
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13. Respostas bioquímicas e fisiológicas de plantas de citros atingidas pelo glyphosate / Biochemical and physiological citrus plants responses under glyphosate application
The objective of this research was to evaluate physiological and biochemical responses of citrus (Citrus spp.) plants sprayed with the herbicide glyphosate. Four studies were done to attain this objective. By the first one, it were investigated the effects of glyphosate (dosages from 0 to 720 g a.e.ha-1 applied on plants canopies) on the leaf contents of shi
Publicado em: 2006
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14. Papel dos receptores GABA-benzodiazepínicos da matéria cinzenta periaquedutal na modulação da ansiedade em camundongos ingênuos e reexpostos ao labirinto em cruz elevado.
Sabe-se que a experiência prévia ao labirinto em cruz elevado (LCE) aumenta a esquiva de roedores aos braços abertos e compromete o efeito ansiolítico de benzodiazepínicos em uma exposição subseqüente ao aparelho, um fenômeno conhecido como one trial tolerance (OTT). Este estudo avaliou os efeitos da administração do benzodiazepínico midazolam (M
Publicado em: 2006
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15. Estudo comparativo do conforto e efeitos adversos de interfaces para ventilaÃÃo nÃo invasiva em voluntÃrios sadios / Comparative study of the comfort and adverse effect of interfaces for not invasive ventilation in healthy volunteers
Rationale: Non-invasive ventilation (NIV) is defined as a ventilatory support technique using an interface (usually a mask) instead of tracheal intubation to adapt the patientâs respiratory system to the ventilator. Although it is as efficacious as the invasive method in terms of improving gas exchange in patients with respiratory failure due to various eti
Publicado em: 2006
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16. Changes in the biogenic amine content of the prefrontal cortex, amygdala, dorsal hippocampus, and nucleus accumbens of rats submitted to single and repeated sessions of the elevated plus-maze test
It has been demonstrated that exposure to a variety of stressful experiences enhances fearful reactions when behavior is tested in current animal models of anxiety. Until now, no study has examined the neurochemical changes during the test and retest sessions of rats submitted to the elevated plus maze (EPM). The present study uses a new approach (HPLC) by l
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-12
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17. Neurochemical correlates of the exploratory behaviour in limbics structures of rats submitted to single or repeated sessions on the elevated plus-maze test / Correlatos neuroquímicos em estruturas límbicas do comportamento exploratório de ratos submetidos à exposição única e repetida ao teste do labirinto em cruz elevado
O efeito ansiolítico dos benzodiazepínicos (BZDs) é reduzido depois da primeira exposição ao labirinto em cruz elevado (LCE). Várias hipóteses tem sido formuladas para explicar este fenômeno chamado one-trial tolerance (OTT), entretanto, nenhuma delas é conclusiva. No presente estudo, examinamos este fenômeno através da análise etofarmacológica
Publicado em: 2005
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18. The Randomised Intervention Treatment of Angina (RITA) Trial protocol: a long term study of coronary angioplasty and coronary artery bypass surgery in patients with angina.
The Randomised Intervention Treatment of Angina (RITA) Trial is a prospective, randomised study to compare the short term and long term effects of percutaneous transluminal coronary angioplasty and coronary artery bypass surgery. During the study a register of patients undergoing coronary arteriography at the fourteen participating centres is being maintaine
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19. Effects of Videogame Distraction using a Virtual Reality Type Head-Mounted Display Helmet on Cold Pressor Pain in Children
Objective To test whether a head-mounted display helmet enhances the effectiveness of videogame distraction for children experiencing cold pressor pain. Method Forty-one children, aged 6–14 years, underwent one or two baseline cold pressor trials followed by two distraction trials in which they played the same videogame with and without the helmet in
Oxford University Press.
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20. Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice.
The peptide-Z-Pro-D-Leu, injected daily in mice receiving morphine chronically, was found to prevent development of physical dependence as measured by changes in body temperature and body weight due either to abrupt or to naloxone-induced withdrawal. On the other hand, administration of Z-Pro-D-Leu only on the last day of morphine treatment did not alter the
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21. Effect of oral salbutamol and slow-release aminophylline on exercise tolerance in chronic bronchitis.
In a double-blind placebo-controlled trial in 24 patients fulfilling the MRC criteria for chronic bronchitis, oral salbutamol 4 mg and slow-release aminophylline (Phyllocontin) 450 mg produced similar and significant (p less than 0.05) mean increases in forced expiratory volume in one second (FEV1). A significantly greater increase in mean FEV1 and forced vi
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22. A blind randomised cross-over trial comparing metipranolol 0.3% with timolol 0.25% in open-angle glaucoma: a pilot study.
A blind randomised cross-over study was conducted on 10 patients (20 eyes) to compare the effect in patients with open-angle glaucoma of metipranolol 0.3% with that of timolol 0.25% on intraocular pressure following one month's topical instillation with each preparation alone. There was no statistically significant difference in intraocular pressure reductio
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23. The effect of aerosol ipratropium bromide and salbutamol on exercise tolerance in chronic bronchitis.
In a double-blind placebo controlled trial in 24 patients fulfilling the MRC criteria for chronic bronchitis, ipratropium bromide 40 microgram and salbutamol 200 microgram produced similar and significant (P less than 0.001) increases in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). A greater increase in FEV1 and FVC was seen
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24. Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine.
Tacrine has been studied in two clinical trials of identical design in patients with probable Alzheimer disease. One trial enrolled patients in the United States, while the other enrolled patients in France. A population pharmacodynamic model has been used to describe the cognitive component of the Alzheimer disease assessment scale (ADASC) using mixed effec