Olanzapine
Mostrando 1-12 de 51 artigos, teses e dissertações.
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1. Clozapine prescription trends in Brazil in the last decade
Objective: Clozapine is a second-generation antipsychotic indicated for treatment-resistant schizophrenia. Studies in several countries have shown a low rate of clozapine use despite the fact that approximately 30% of schizophrenia cases are treatment-resistant. In Brazil, few studies have addressed the frequency and variety of antipsychotic use in individua
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Facial processing in bipolar disorder is mediated by clinical and biological aspects
Objective: The process of detecting faces can be considered one of the initial steps in face recognition, which is essential for human interaction. We sought to investigate whether a face perception task reliably detects subtle perceptual disturbances between patients with bipolar disorder (BD) and healthy controls. Methods: In this multisite study, we exam
Brazilian Journal of Psychiatry. Publicado em: 2022
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3. Health-related quality of life in patients treated with atypical antipsychotics
Objective: To assess health-related quality of life and associated factors in patients treated with atypical antipsychotics, as well as to determine utility values using the EuroQol-5D-3L instrument. Methods: A cross-sectional study was conducted at a state-run pharmacy in the Brazilian National Health System. Individuals were included if they were using a
Braz. J. Psychiatry. Publicado em: 2020-12
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4. Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs
Antipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes mellitus. The study was designed to assess various biochemic
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
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5. Sex-differential effects of olanzapine vs. aripiprazole on glucose and lipid metabolism in first-episode schizophrenia
Abstract Objective To compare sex difference in metabolic effect of olanzapine versus aripiprazole on schizophrenia. Methods A twelve-week prospective open-label cohort study to compare four subgroups according to first-episode schizophrenia patients’ type of drug usage and sex: female aripiprazole (n = 11), male aripiprazole (n = 11), female olanzapin
Arch. Clin. Psychiatry (São Paulo). Publicado em: 06/06/2019
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6. Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
Olanzapine and risperidone are widely prescribed atypical antipsychotics used in the treatment of schizophrenia and various other psychiatric disorders. Both of these drugs have been extensively reported to cause Type 2 diabetes mellitus and pancreatitis, however, the mechanism of olanzapine and risperidone-induced toxicity has not been so far unveiled. We,
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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7. Effect of pH on weakly acidic and basic model drugs and determination of their ex vivo transdermal permeation routes
ABSTRACT The aim of the present study was to investigate the effect of donor pH on the transdermal permeability of the model drugs across rat skin and also to determine the major route of transport of the drugs. Weakly acidic drugs (partition coefficient) ibuprofen (3.6), aceclofenac (3.9), glipizide (1.9) and weakly basic drugs olanzapine (3.6), telmisartan
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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8. DELIRIUM EM IDOSOS: REVISÃO SISTEMÁTICA DE TRATAMENTOS FARMACOLÓGICOS E NÃO-FARMACOLÓGICOS
RESUMO Delirium é uma condição comum associada com prognóstico pobre, especialmente em idosos. O impacto das diferentes abordagens de tratamento na morbi-mortalidade e bem-estar de longo prazo não é completamente compreendido. OBJETIVO: Determinar a eficácia dos tratamentos farmacológico e não-farmacológico em pacientes idosos com delirium. MÉTO
Dement. neuropsychol.. Publicado em: 2017-09
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9. The Use of Near Infrared Spectroscopy and Multivariate Calibration for Determining the Active Principle of Olanzapine in a Pharmaceutical Formulation
The aim of this study was to quantitatively determine the olanzapine in a pharmaceutical formulation for assessing the potentiality of near infrared spectroscopy (NIR) combined with partial least squares (PLS) regression. The method was developed with samples based on a commercial formulation containing olanzapine and seven excipients. Laboratory and commerc
J. Braz. Chem. Soc.. Publicado em: 2017-05
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10. Psychotic syndrome secondary to meningioma treated with a low dose of olanzapine
Rev. Bras. Psiquiatr.. Publicado em: 2015-06
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11. Meta-analysis on the efficacy and tolerability of the augmentation of antidepressants with atypical antipsychotics in patients with major depressive disorder
We assessed the efficacy and tolerability of the augmentation of antidepressants (ATDs) with atypical antipsychotics (AAPs) to treat patients with major depressive disorder. A retrograde study to identify relevant patient data included databases of PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Database of Abstracts of Reviews of Effects
Braz J Med Biol Res. Publicado em: 13/06/2014
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12. LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using small plasma volume (0.1 mL) to apply in a preclinical pharmacokinetic investigation. The method was linear over the concentration ranges o
Quím. Nova. Publicado em: 2014