Novel Object Recognition
Mostrando 13-16 de 16 artigos, teses e dissertações.
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13. Neurology of anomia in the semantic variant of primary progressive aphasia
The semantic variant of primary progressive aphasia (PPA) is characterized by the combination of word comprehension deficits, fluent aphasia and a particularly severe anomia. In this study, two novel tasks were used to explore the factors contributing to the anomia. The single most common factor was a blurring of distinctions among members of a semantic cate
Oxford University Press.
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14. Hippocampal Damage and Exploratory Preferences in Rats: Memory for Objects, Places, and Contexts
Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from th
Cold Spring Harbor Laboratory Press.
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15. Working memory deficits in retinoid X receptor γ-deficient mice
Retinoid signaling has been recently shown to be required for mnemonic functions in rodents. To dissect the behavioral and molecular mechanisms involved in this requirement, we have analyzed the spatial and recognition working memory in mice carrying null mutations of retinoid receptors RARβ and RXRγ. Double mutants appeared deficient in spatial working me
Cold Spring Harbor Laboratory Press.
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16. A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4
Mice carrying a truncated form of cAMP-responsive element binding protein (CREB)-binding protein (CBP) show several developmental abnormalities similar to patients with Rubinstein-Taybi syndrome (RTS). RTS patients suffer from mental retardation, whereas long-term memory formation is defective in mutant CBP mice. A critical role for cAMP signaling during
National Academy of Sciences.