Normal And Pathological Ageing
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Effects of ageing on cognitive performance / Efeitos do envelhecimento sobre o desempenho cognitivo
This research aims to offer a contribution about human ageing process, trying to show that there are important differences between normal and pathological ageing processes, specially when we focus on cognitive aspects. An epidemiologic-descriptive and transversal method was used, with a sample of 88 participants, with ages equal or superior to 60 years. The
Publicado em: 2005
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2. ACTH and cortisol secretion in patients with Alzheimer's disease.
The "glucocorticoid cascade hypothesis" for pathological ageing of the brain is supported by strong experimental data, but the clinical correlates are far less clear. The basal ACTH and cortisol secretion have been studied before and after the dexamethasone suppression test in patients in the early stages of clinically probable Alzheimer's disease and in con
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3. Age-related degenerative changes in the mouse mandibular joint.
The mandibular joints of ageing male ICR mice were studied by light and electron microscopy. A high incidence of degenerative joint disease was found relatively early in adult life, osteoarthrosis being evident by the seventh month. Initially the pathological changes were those of chondromalacia confined to isolated foci on the articular surface of the condy
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4. Small bowel enterocyte abnormalities caused by methotrexate treatment in acute lymphoblastic leukaemia of childhood.
Jejunal biopsy specimens from 10 children with acute lymphoblastic leukaemia on methotrexate treatment were compared with 10 from children being investigated for diarrhoea or failure to thrive. In association with methotrexate treatment on both light and electron microscopy, there were marked morphological abnormalities in the villus enterocytes. These consi
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5. Ageing and degeneration in the macular region: a clinico-pathological study.
Clinical and pathological examination was performed on 378 eyes from 216 patients aged 43 to 97 years. This series represented eyes in which the fundi were normal or showed various manifestations of senile macular degeneration. The eyes were divided into six groups according to the histological appearance of a linear deposit at the base of the retinal pigmen
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6. Subclinical peripheral nerve involvement in AIDS: an electrophysiological and pathological study.
Thirty patients with AIDS without symptoms or signs of peripheral neuropathy were compared electrophysiologically with 23 age and sex matched healthy controls. The patients had a mean reduction in the amplitude of common peroneal compound muscle action potentials of 37% (95% CI 11-70%) and of sural sensory action potentials of 34% (CI 18-49%). Mean conductio
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7. Extracellular matrix, supramolecular organisation and shape.
Connective tissue function is defined as the formation and maintenance of shape, without which centralised physiologies (circulatory, digestive or nervous) could not have evolved. Two elements, inextensible (collagenous) fibrils and compression-resistant interfibrillar soluble polymers (proteoglycans), cope with all usual stresses. Relationships between the