Nitro Compounds
Mostrando 13-24 de 135 artigos, teses e dissertações.
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13. Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes
Abstract Background: Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required. Nitro-heterocyclic derivatives have been used a
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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14. Synthesis and in vitro anti-HIV-1 evaluation of some N-arylsulfonyl-3-formylindoles
As our ongoing work on research of anti-HIV-1 inhibitors, fifteen N-arylsulfonyl-3-formylindoles (3a-o) were designed and prepared through two step synthetic route. Firstly, 3-formylindoles (2a-c) were synthesized via the Vilsmeier-Haack reaction. Subsequently, treatment of 2a-c with the appropriate arylsulfonyl chlorides led to the corresponding target comp
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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15. In vitro Evaluation of Oxidative Stress Caused by Fine Particles (PM2.5) Exhausted from Heavy-Duty Vehicles Using Diesel/Biodiesel Blends under Real World Conditions
In this work, the redox activity of fine diesel/biodiesel particulate matter (PM2.5) was studied in order to approach its toxicity from reactive oxygen species, due to adverse effects it may cause to human health. The oxidative potential was measured by the dithiothreitol (DTT) assay in order to study the relative contribution of water-soluble transition met
J. Braz. Chem. Soc.. Publicado em: 2018-06
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16. Preparation of Derivatives of Betulinic Acid, Steviol and Isosteviol and Evaluation of Antitrypanosomal and Antimalarial Activities
Derivatives of steviol, isosteviol and betulinic acid were prepared and tested in vitro against Plasmodium falciparum W2 (chloroquine-resistant) and Trypanosoma cruzi. The best results against P. falciparum were found for the betulinic acid derivatives 3-[(2,4-dinitrophenyl)hydrazono]lup-20(29)-en-28-oic acid and 3-hydroxy-20-[(2,4-dinitrophenyl)hydrazono]-2
J. Braz. Chem. Soc.. Publicado em: 2016-06
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17. Conformational Variability in Sulfonamide Chalcone Hybrids: Crystal Structure and Cytotoxicity
Four sulfonamide-chalcone derivatives were prepared and their crystal structure were elucidated by single-crystal X-ray diffraction technique. They were synthesized by Claisen-Schmidt condensation reaction between N-(4-acetylphenyl)benzenesulfonamide or N-(4-acetylphenyl)-2,5-dichlorobenzenesulfonamide with benzaldehyde or p-nitrobenzaldehyde. Values of Z' >
J. Braz. Chem. Soc.. Publicado em: 2016-05
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18. Zwitterionic Surfactant Stabilized Palladium Nanoparticles as Catalysts in Aromatic Nitro Compound Reductions
Palladium nanoparticles (NPs) stabilized by ImS3-14, a zwitterionic surfactant structurally related to ionic liquids, are revealed here to be good catalysts for the reduction of a large number of substituted aromatic nitro compounds. Our mass spectrometry results are consistent with the formation of amino products in a direct route, where the aromatic nitro
J. Braz. Chem. Soc.. Publicado em: 2016-02
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19. Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group
Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic properties have been attributed to the presence of the nitro group. However, we synthesised nitroimidazoles with activity against the trypomastigotes of Trypanosoma cruzi, but that were not genotoxic. Herein, nitroimidazoles (11-19) bearing different substituent groups
Mem. Inst. Oswaldo Cruz. Publicado em: 26/05/2015
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20. Anti-Trypanosoma cruzi compounds: our contribution for the evaluation and insights on the mode of action of naphthoquinones and derivatives
A doença de Chagas causada pelo Trypanosoma cruzi afeta cerca de oito milhões de pessoas em países em desenvolvimento, sendo classificada como uma doença tropical negligenciada pela Organização Mundial da Saúde. A quimioterapia disponível para esta doença é baseada em dois nitro-heterocíclicos, nifurtimox e benznidazol, ambos com graves efeitos co
J. Braz. Chem. Soc.. Publicado em: 2014-10
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21. Dft theoretical study of energetic nitrogen-rich C4N6H8-n(NO2)n derivatives
Density functional theory (DFT) calculations at the B3LYP/6-31G** theoretical level were performed for a series of guanidine-fused bicyclic skeleton derivatives C4N6H8-n(NO2)n (n = 1 - 6). The heats of formation (HOFs) were calculated by isodesmic reactions, and the detonation properties were evaluated using the Kamlet - Jacobs equations. The bond dissociati
Quím. Nova. Publicado em: 2014
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22. ReaÃÃes biocatalÃticas usando cÃlulas Ãntegras de Lens culinaris (Lentilha). / REACTIONS USING WHOLE CELL BIOCATALYTIC LENS CULINARIS (LENTIL)
This paper describes the use of seeds of lentil (Lens culinaris) as intact plant system in biocatalytic reactions of reduction and hydrolysis. Initially, some plant sources were evaluated for their action in the biocatalytic reduction of aromatic ketone acetophenone. The plants that showed positive results in the reduction reaction underwent determination of
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/10/2012
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23. Planejamento, síntese e avaliação da atividade anti-T. cruzi de derivados furfurilidênicos com estruturas azometínica e oxadiazolínica / Design, synthesis, identification and anti-Trypanosoma cruzi activity evaluation of furfurylidene azomethine and oxadiazole derivatives
The search for alternative therapies for the treatment of Chagas disease presents great importance, since there are only two currently available drugs, nifurtimox and benznidazole. Both have considerable adverse effects and, in Brazil, is used only benznidazole. Nitro-heterocyclic compounds with activity against Trypanosoma cruzi, the causative agent of Chag
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2012
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24. SYNTHESIS,CHARACTERIZATION AND THEORETICAL STUDY OF ORTHO-SUBSTITUTED SCHIFF BASES AND THEIR COPPER(II) COMPLEXES AS POTENTIAL ANTITUMOR AGENTS / SÍNTESE, CARACTERIZAÇÃO E ESTUDO TEÓRICO DE BASES DE SCHIFF ORTO-SUBSTITUÍDAS E SEUS COMPLEXOS DE COBRE(II) COMO POTENCIAIS AGENTES ANTITUMORAIS
Nowadays, the neoplastic processes have been one of the most concern diseases. The malignance tumor, also called cancer, is the most aggravating pathological process, responsible for the death of the patient in most cases. In this context, several drugs have been designed with the objective to eliminate the cancer cells selectively; among them, some coordina
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2012