Nitazoxanide
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Inhibition of Brazilian ZIKV strain replication in primary human placental chorionic cells and cervical cells treated with nitazoxanide
ABSTRACT Zika virus (ZIKV) infection during pregnancy is associated with a congenital syndrome. Although the virus can be detected in human placental tissue and sexual transmission has been verified, it is not clear how the virus reaches the fetus. Despite the emerging severity caused by ZIKV infection, no specific prophylactic and/or therapeutic treatment i
Braz J Infect Dis. Publicado em: 2020-12
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2. Antimicrobial susceptibility of Brazilian Clostridium difficile strains determined by agar dilution and disk diffusion
Abstract Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate rec
Braz J Infect Dis. Publicado em: 2016-10
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3. Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with HPLC
A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of
Química Nova. Publicado em: 2010
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4. Nitazoxanida : desenvolvimento e validação de métodos analíticos e estudo da estabilidade / Nitazoxanide: development and validation of analytical methods and stability study
A nitazoxanida é um novo antiparasitário de amplo espectro e pertence à classe dos nitrotiazóis. No Brasil, encontra-se disponível na forma de comprimidos revestidos e pó para suspensão oral, sob nome cormercial de Annita . A análise de fármacos é necessária em todas as fases do desenvolvimento farmacêutico e na manutenção da segurança e efic�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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5. Stripping voltammetric methods for determination of the antiparasitic drug nitazoxanide in bulk form, pharmaceutical formulation and human serum
Voltamogramas cíclicos de nitazoxanida medidos no eletrodo de gota de mercúrio no tampão universal Britton-Robinson com valores de pH de 2 a 11 contendo 20% (v/v) de etanol exibiram um único pico catódico irreversível de 4-elétrons, correspondendo à redução de seu grupo NO2 para hidroxilamina. Observou-se que a nitazoxanida adsorve na superfície d
Journal of the Brazilian Chemical Society. Publicado em: 2010
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6. ENSAIO CLÍNICO RANDOMIZADO DA NITAZOXANIDA NO TRATAMENTO DE POLIPARASITOSES INTESTINAIS EM MUNICÍPIOS DA ZONA DA MATA, MINAS GERAIS / Random clinical test of the nitazoxanide in the treatment of intestinal poliparasitism in cities in Zona da Mata, Minas Gerais
As parasitoses intestinais são um importante problema de saúde pública principalmente nos países subdesenvolvidos ou em desenvolvimento. Embora o parasitismo intestinal seja amplamente reconhecido como relevante no contexto epidemiológico de diversas comunidades, os estudos sobre o assunto são ainda insuficientes, principalmente no Brasil. Em vista da
Publicado em: 2009
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7. In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms.
The antibacterial activities of nitazoxanide and its main metabolite, tizoxanide, were tested against a broad range of bacteria, including anaerobes. Metronidazole, amoxicillin, amoxicillin-clavulanic acid, piperacillin, cefoxitin, imipenem, and clindamycin were used as positive controls. MICs were determined by reference agar dilution methods. The 241 anaer
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8. Nitazoxanide, a Potential Drug for Eradication of Helicobacter pylori with No Cross-Resistance to Metronidazole
Nitazoxanide, a thiazolide compound, and its desacetyl derivative, tizoxanide, have antimicrobial properties against anaerobic bacteria, as well as against helminths and protozoa. Because the treatment of Helicobacter pylori infection may be jeopardized by metronidazole resistance, nitazoxanide and tizoxanide were tested in vitro against these bacteria. The
American Society for Microbiology.
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9. Successful Treatment with Nitazoxanide of Enterocytozoon bieneusi Microsporidiosis in a Patient with AIDS
A patient with AIDS and chronic diarrhea caused by Enterocytozoon bieneusi was successfully treated with nitazoxanide, producing a complete clinical and parasitological response, while off of antiviral therapy. This suggests that nitazoxanide may be effective in treating microsporidiosis caused by E. bieneusi, a disease for which there is no established trea
American Society for Microbiology.
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10. Nitazoxanide in Treatment of Helicobacter pylori: a Clinical and In Vitro Study
Nitazoxanide (NTZ) is an antibiotic with microbiological characteristics similar to those of metronidazole but without an apparent problem of resistance. The aim of this study was the prospective evaluation of NTZ given as a single agent in the treatment of Helicobacter pylori infection. Twenty culture-positive patients with dyspepsia who had previously fail
American Society for Microbiology.
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11. Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori
Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species. Here we describe development and use of a spectrophotometric assay, based on nitroreduction of NTZ at 412 nm, to identify H. pylori enzymes responsible for its activation and mode of act
American Society for Microbiology.
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12. Efficacy of Nitazoxanide against Cryptosporidium parvum in Cell Culture and in Animal Models
Nitazoxanide (NTZ), a drug currently being tested in human clinical trials for efficacy against chronic cryptosporidiosis, was assessed in cell culture and in two animal models. The inhibitory activity of NTZ was compared with that of paromomycin (PRM), a drug that is partially effective against Cryptosporidium parvum. A concentration of 10 μg of NTZ/ml (32
American Society for Microbiology.