Nigrostriatal
Mostrando 1-12 de 74 artigos, teses e dissertações.
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1. O ESTILO DE VIDA ATIVO MELHORA O PERFIL DE EXPRESSÃO DE PROTEÍNAS EM INDIVÍDUOS COM A PATOLOGIA DE CORPOS DE LEWY
RESUMO. Estudos dos efeitos da atividade física relataram melhora nos sintomas e na qualidade de vida de pacientes com doença de Parkinson (DP). Além disso, alterações morfológicas do cérebro após o exercício físico foram relatadas em modelos animais da DP. No entanto, essas mudanças relacionadas ao estilo de vida não foram avaliadas em tecido ce
Dement. neuropsychol.. Publicado em: 2021-03
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2. Benefits of physical exercise on Parkinson’s disease disorders induced in animal models
Abstract Aim: The preventive and therapeutic role of physical exercise in Parkinson’s disease (PD) has been the target of study of many scientific groups, and the research often is done in experimental models, especially rodents. Thus, the aim of this review was to analyze a database, elucidating the main benefits that the systematized practice of physic
Motriz: rev. educ. fis.. Publicado em: 21/10/2019
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3. Efeitos da ovariectomia e treinamento de força na concentração tecidual de dopamina e serotonina na via nigroestriatal e mesolímbica de ratas
O estrogênio é um hormônio esteróide conhecido por representar um papel relevante nos eventos celulares do desenvolvimento, manutenção da fisiologia do corpo e ações moduladoras no sistema nervoso central (SNC) durante a vida. O objetivo do presente estudo foi investigar o efeito da ovariectomia (OVX) e da intervenção do treinamento de força sobre
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/02/2011
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4. Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl- D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 μg 6-OHDA (6-OHDA group) or vehicle (artificial cerebrospinal
Publicado em: 2011
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5. Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl-D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 mg 6-OHDA (6-OHDA group) or vehicle (artificial cerebrospinal fl
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-01
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6. EFEITOS DOS NEUROLÉPTICOS ATÍPICOS ZIPRASIDONA E AMISULPRIDA EM MODELOS ANIMAIS DE DISCINESIA TARDIA.
Tardive dyskinesia - the main side effect of long-term treatment with typical neuroleptics - has been related to nigrostriatal dopaminergic supersensitivity. Treatment with atypical neuroleptics is associated with a decreased risk for development of tardive dyskinesia. The aim of the present study was to verify the effects of several doses the atypical neuro
Publicado em: 2009
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7. Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta
Dopaminergic neurotransmission is involved in the regulation of sleep. In particular, the nigrostriatal pathway is an important center of sleep regulation. We hypothesized that dopaminergic neurons located in substantia nigra pars compacta (SNpc) could be activated by gentle handling, a method to obtain sleep deprivation (SD). Adult male C57/BL6J mice (N = 5
Brazilian Journal of Medical and Biological Research. Publicado em: 30/09/2008
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8. O papel do sistema dopaminérgico nigroestriatal na neurobiologia do sono / The role of the dopaminergic nigrostriatal system in the sleep neurobiology.
Dopamine (DA) is critically involved in regulating neural processes responsible for complex movements and emotions. Alterations in central dopaminergic neurotransmission have been implicated in important neurological and psychiatric disorders such as Parkinsons disease (PD) and schizophrenia. In addition, DA has recently been recognized as instrumental in th
Publicado em: 2008
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9. Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in mice
Depression found in Parkinson disease (PD) usually responds to selective serotonin reuptake inhibitors (SSRIs). Drugs that modify experimental neuroleptic catalepsy (NC) might affect extrapyramidal symptoms in PD. Therefore, the effects of SSRIs on NC were tested in mice, 26-36 g, separated by sex. Catalepsy was induced with haloperidol (H; 1 mg/kg, ip) and
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-12
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10. 123-I ioflupane (Datscan®) presynaptic nigrostriatal imaging in patients with movement disorders
A imagem pré-sináptica através de 123-I Ioflupane (Datscan®) tem mostrado um papel significante na avaliação de pacientes com distúrbios do movimento. 123-I Ioflupane SPECT é capaz de distinguir entre Mal de Parkinson (MP) e outras formas de parkinsonismo sem degenerações da via nigroestriatal incluindo um distúrbio comum de movimento parecido com
Brazilian Archives of Biology and Technology. Publicado em: 2005-10
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11. Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice
It has been suggested that nigrostriatal dopaminergic transmission is modulated by nitric oxide (NO). Since there is evidence that gonadal hormones can affect extrapyramidal motor behavior in mammals, we investigated the effects of isosorbide dinitrate (ISD), linsidomine (SIN-1) and S-nitroso-N-acetylpenicillamine (SNAP), three pharmacologically different NO
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-02
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12. Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum
Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in the control of dopamine release. To test this hypothesis, we used a classical model of unilateral selective lesion of these neurons in rats based on 6-hydroxydopamine (6-OHDA) injection into the substantia nigra. B
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-02