Nifedipine
Mostrando 1-12 de 362 artigos, teses e dissertações.
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1. Influence of sonication and in vitro evaluation of nifedipine self-nanoemulsifying drug delivery system
In order to develop a self-nanoemulsifying system, three components, olive oil, Tween 80, and Capmul, were used to construct a ternary phase diagram that helped to find the optimum formulation, which was loaded with nifedipine. The effect of sonication on drug loading was also evaluated. After that, measurement of the droplet size, size distribution, zeta po
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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2. Prescription of potentially inappropriate medication for the elderly: comparing health service providers
Resumo Objetivo: Comparar a prescrição de medicamentos em idosos usuários do SUS com usuários de Plano de Saúde Suplementar à luz dos critérios de Beers. Método: Trata-se de uma análise documental, quantitativa, utilizando dois bancos de dados, obtidos a partir de pesquisas realizados no mesmo município. No primeiro, a amostra incluiu 532 pessoas
Rev. bras. geriatr. gerontol.. Publicado em: 05/08/2019
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3. Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys
Abstract Objective: Myofibroblasts have been associated with the development of several pathologic fibrotic conditions. This longitudinal study aims to assess the proliferative and antiapoptotic effects of cyclosporin, nifedipine and phenytoin on gingival connective tissue cells of nonhuman primate, as well as to analyze a possible role of myofibroblasts in
J. Appl. Oral Sci.. Publicado em: 08/11/2018
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4. Promotion of cutaneous penetration of nifedipine for nanoemulsion
ABSTRACT This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index (IP<0.1), spherical shape without aggregation, pH compatible with typical skin levels and stabil
Braz. J. Pharm. Sci.. Publicado em: 06/07/2017
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5. DEVELOPMENT OF ORAL NIFEDIPINE-LOADED POLYMERIC NANOCAPSULES: PHYSICOCHEMICAL CHARACTERISATION, PHOTOSTABILITY STUDIES,
IN VITRO ANDIN VIVO EVALUATIONIn this study, nifedipine (NFP)-loaded polymeric nanocapsules were prepared and characterised with a view to protect the drug from degradation. Nanocapsule suspensions were prepared using two different surfactants (pluronic F68 and polyvinyl alcohol). Physicochemical stability and
in vivo antihypertensive effect were evaluated. The particlQuím. Nova. Publicado em: 2015-07
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6. Investigation of the Environmental Transport of Human Pharmaceuticals to Surface Water: A Case Study of Persistence of Pharmaceuticals in Effluent of Sewage Treatment Plants and Hospitals in Malaysia
The present work reports the occurrence and monitoring of 11 pharmaceuticals (i.e., caffeine, prazosin, enalapril, carbamazepine, nifedipine, gliclazide, levonorgestrel, simvastatin, hydrochlorothiazide, diclofenac-Na and mefenamic acid) in surface water and in the influent and effluent of sewage treatment plants (STPs) and hospitals (HSPs). A total of 105 w
J. Braz. Chem. Soc.. Publicado em: 2015-06
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7. Nifedipine-induced histological changes in the parotid glands of hypertensive rats
Nifedipine is a widely used anti-anginal and anti-hypertensive agent. It is associated with significant gingival changes attributed more to collagen hyperplasia than to enhancement of protein synthesis. We investigated the influence of nifedipine on morphological changes in the parotid glands of rats in a model of hypertension. Twenty-eight male Wistar rats
Braz. oral res.. Publicado em: 11/06/2014
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8. Antischistosomal activity of a calcium channel antagonist on schistosomula and adult Schistosoma mansoni worms
Current schistosomiasis control strategies are largely based on chemotherapeutic agents and a limited number of drugs are available today. Praziquantel (PZQ) is the only drug currently used in schistosomiasis control programs. Unfortunately, this drug shows poor efficacy in patients during the earliest infection phases. The effects of PZQ appear to operate o
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-08
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9. Influência do nifedipino na disposição cinética dos enantiômeros da venlafaxina e seus metabólitos em voluntários sadios / Influence of nifedipine on the kinetic disposition of venlafaxine enantiomers and its metabolites in healthy volunteers
A venlafaxina é um fármaco usado no tratamento da depressão e dos transtornos de ansiedade generalizada. É disponível na clínica na forma de mistura racêmica dos enantiômeros S-(+) e R-(-) em formulação de liberação controlada. O enantiômero S-(+) inibe a recaptação da serotonina, enquanto o enantiômero R-(-) inibe a recaptação da serotonin
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/06/2012
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10. Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures
Calcium ion participates in the regulation of neural transmission and the presynaptic release of neurotransmitters. It is also involved in epileptic events, cardiac arrhythmias and abnormal conduction of stimuli. The purpose of the present study was to evaluate the effects of nifedipine, a calcium channel blocker, on epileptic seizures and on reperfusion arr
Braz J Med Biol Res. Publicado em: 2012-11
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11. Arginine induces GH gene expression by activating NOS/NO signaling in rat isolated hemi-pituitaries
The amino acid arginine (Arg) is a recognized secretagogue of growth hormone (GH), and has been shown to induce GH gene expression. Arg is the natural precursor of nitric oxide (NO), which is known to mediate many of the effects of Arg, such as GH secretion. Arg was also shown to increase calcium influx in pituitary cells, which might contribute to its effec
Braz J Med Biol Res. Publicado em: 2012-11
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12. Solubility enhancement, physicochemical characterization and formulation of fast-dissolving tablet of nifedipine-betacyclodextrin complexes
Este estudo teve por objetivo principal incrementar a dissolução do nifedipino, fármaco pouco solúvel em água, por meio de sua complexação com β-ciclodextrina e estudar o efeito do método de preparação sobre o perfil de dissolução in vitro. A razão estequiométrica, determinada por ensaio de solubilidade de fase, para a complexação de nifedip
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2012-03