Nicotinic Receptors
Mostrando 13-24 de 287 artigos, teses e dissertações.
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13. Analise histologica do aparato venenifero e caracterização farmaco-bioquimica da peçonha de Vitalius dubius (Araneae, Theraphosidae) / Histological analysis of the venom apparatus and biochemical and pharmacological characterization of venom from Vitalius dubius (Araneae, Theraphosidae)
Vitalius dubius is a medium-sized, non-aggressive tarantula found in southeastern Brazil. In this work, we examined the histological organization of the venom apparatus of V. dubius and investigated some biochemical and pharmacological properties of this spider´s venom. The venom apparatus consisted of two chelicerae fitted with large fangs for prey immobil
Publicado em: 2008
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14. Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells
The influence of melatonin on the developmental pattern of functional nicotinic acetylcholine receptors was investigated in embryonic 8-day-old chick retinal cells in culture. The functional response to acetylcholine was measured in cultured retina cells by microphysiometry. The maximal functional response to acetylcholine increased 2.7 times between the 4th
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-04
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15. Ectopic development of skeletal muscle induced by subcutaneous transplant of rat satellite cells
The present study analyzes the ectopic development of the rat skeletal muscle originated from transplanted satellite cells. Satellite cells (10(6) cells) obtained from hindlimb muscles of newborn female 2BAW Wistar rats were injected subcutaneously into the dorsal area of adult male rats. After 3, 7, and 14 days, the transplanted tissues (N = 4-5) were proce
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-03
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16. Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors
Na última década vários sistemas de neurotransmissores têm sido relacionados ao controle do desenvolvimento do sistema nervoso. Nesta revisão, nós discutimos as evidências de que os receptores nicotínicos da acetilcolina podem apresentar uma função incomum durante o desenvolvimento, que não deve estar relacionada com seu papel na neurotransmissão
Anais da Academia Brasileira de Ciências. Publicado em: 2002-09
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17. Evaluation of the cholinomimetic actions of trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana (Gastropoda, Opisthobranchia)
Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses. In the present study, the pharmacological profile of trimethylsulfonium was characterized on muscarinic and nicotinic acetylcholine receptors. In rat jejunum the co
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-04
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18. "Nicotinic acetylcholine receptors in the chick retina in culture development: modulation by endogenous melatonin" / "Receptores nicotínicos de acetilcolina no desenvolvimento da retina de pinto em cultura: modulação por melatonina endógena"
Receptores nicotínicos da acetilcolina são encontrados na retina de pintos desde o início do desenvolvimento embrionário. As propostas desse trabalho foram caracterizar esses receptores no desenvolvimento de células de retinas embrionárias de pinto com oito dias, em cultura, e investigar se luzindole, um antagonista de receptores de melatonina, interfe
Publicado em: 2002
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19. Frequent occurrence of nicotinic acetylcholine receptors in GABAergic neurons of the chick visual system
Double-labeling immunohistochemical methods were used to investigate the occurrence of the alpha8 and alpha5 nicotinic receptor subunits in presumptive GABAergic neurons of the chick nervous system. Nicotinic receptor immunoreactivity was often found in cells exhibiting GABA-like immunoreactivity, especially in the visual system. The alpha8 subunit appeared
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-10
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20. Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines.
alpha-Bungarotoxin (alpha Bgtx) is a toxin known to interact with muscle nicotinic receptors and with some neuronal nicotinic receptors. We show that alpha Bgtx binding sites are also expressed in nonmuscle and nonneuronal human cells, including small cell lung carcinoma and several epithelial cell lines. These receptors are immunologically related to the al
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21. Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac)
Fluoxetine (Prozac), a widely used antidepressant, is said to exert its medicinal effects almost exclusively by blocking the serotonin uptake systems. The present study shows that both muscle and neuronal nicotinic acetylcholine receptors are blocked, in a noncompetitive and voltage-dependent way, by fluoxetine, which also increases the rate of desensitizati
The National Academy of Sciences of the USA.
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22. Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family.
A family of genes coding for proteins homologous to the alpha subunit of the muscle nicotinic acetylcholine receptor has been identified in the rat genome. These genes are transcribed in the central and peripheral nervous systems in areas known to contain functional nicotinic receptors. In this paper, we demonstrate that three of these genes, which we call a
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23. The Conformation of Cholinergic Molecules at Nicotinic Nerve Receptors
A correlation of the crystal structure analyses of the potent nicotinic agonists acetylcholine, acetyl-α-methylcholine, lactoylcholine, 1,1-dimethyl-4-phenylpiperazine, and nicotine allows one to determine the conformation of cholinergic agonists relevant to nicotinic nerve receptors.
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24. Strychnine activates neuronal α7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains
Recent work has shown that strychnine, the potent and selective antagonist of glycine receptors, is also an antagonist of nicotinic acetylcholine (AcCho) receptors including neuronal homomeric α7 receptors, and that mutating Leu-247 of the α7 nicotinic AcCho receptor-channel domain (L247Tα7; mut1) converts some nicotinic antagonists into agonists. Therefo
The National Academy of Sciences.