Ngal
Mostrando 25-36 de 36 artigos, teses e dissertações.
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25. Effect of allopurinol on the kidney function, histology and injury biomarker (NGAL, IL 18) levels in uninephrectomised rats subjected to ischaemia-reperfusion injury
PURPOSE:To investigate whether allopurinol exerts a protective effect on kidneys by measuring new kidney injury biomarkers (NGALp, NGALu, KIM 1 and IL 18) and analysing the renal function and histology in uninephrectomised rats subjected to ischaemia-reperfusion injury.METHODS: Thirty two Wistar rats were randomly allocated to four groups: Sham (S): laparoto
Acta Cir. Bras.. Publicado em: 2014-08
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26. The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia,
Acta Cir. Bras.. Publicado em: 2013-01
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27. Solução salina hipertônica na insuficiência cardíaca descompensada / Hypertonic saline solution in decompensated heart failure
A ocorrência de disfunção renal em pacientes com insuficiência cardíaca descompensada é evento comum e associado a pior prognóstico. Entretanto, intervenções direcionadas a prevenção e tratamento da disfunção renal nestas circunstâncias revelaram resultados desapontadores. O objetivo deste estudo foi investigar o efeito da solução salina hipe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2012
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28. Lipocalina associada à gelatinase de neutrófilos (NGAL) e calprotectina no tecido laminar de equinos após obstrução jejunal, tratados ou não com hidrocortisona
A laminite é uma doença podal grave que acomete os equídeos, sendo responsável por intenso sofrimento. Neste estudo foram pesquisadas a presença de calprotectina por meio da imunoistoquímica, e de lipocalina associada à gelatinase de neutrófilos (NGAL), por zimografia, no tecido laminar do casco de equinos após obstrução intestinal. Os animais for
Pesq. Vet. Bras.. Publicado em: 2012-09
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29. A evolução da lesão renal aguda em pacientes de terapia intensiva e o Neutrophil Gelatinese Associated Lipocalin (NGAL) / The evolution of the acute kidney injury in critical care patients and the Neutrophil Gelatinase Associated Lipocalin (NGAL)
Introdução: A lesão renal aguda (LRA) ocorre em unidades de terapia intensiva (UTI), com incidência de 30%, enquanto que a incidência hospitalar é 3-5%. A mortalidade nestes pacientes, inalterada nas últimas décadas, varia entre 50 e 70%. O padrão clínico para diagnóstico da LRA é a dosagem da creatinina sérica, que é um método pouco sensível
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/12/2011
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30. Lipocalina associada com gelatinase de neutrófilos humanos (ngal) para o diagnóstico da injúria renal aguda após transplante de rim
Introdução: Na Nefrologia, e em particular nos transplantes renais, houve uma substancial evolução nos últimos anos. Atualmente a Lipocalina Associada à Gelatinase dos Neutrófilos Humanos (NGAL) é considerado um biomarcador precoce de injúria renal nos pacientes transplantados de rim. Metodologia: A revisão sistemática com enfoque diagnóstico –
Publicado em: 2010
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31. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
Neutrophil gelatinase–associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This complex converts renal progenitors into epithelial tubules. In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney epithelial cells or accelerates their recovery from damage
American Society for Clinical Investigation.
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32. Urinary NGAL Marks Cystic Disease in HIV-Associated Nephropathy
Nephrosis and a rapid decline in kidney function characterize HIV-associated nephropathy (HIVAN). Histologically, HIVAN is a collapsing focal segmental glomerulosclerosis with prominent tubular damage. We explored the expression of neutrophil gelatinase-associated lipocalin (NGAL), a marker of tubular injury, to determine whether this protein has the potenti
American Society of Nephrology.
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33. Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells.
The mechanism of protein targeting to individual granules in cells that contain different subsets of storage granules is poorly understood. The neutrophil contains two highly distinct major types of granules, the peroxidase positive (azurophil) granules and the peroxidase negative (specific and gelatinase) granules. We hypothesized that targeting of proteins
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34. Urine Neutrophil Gelatinase-Associated Lipocalin Moderately Predicts Acute Kidney Injury in Critically Ill Adults
Urine neutrophil gelatinase-associated lipocalin (uNGAL) has shown promise as a biomarker for the early detection of acute kidney injury (AKI) in fixed models of injury, but its ability to predict AKI and provide prognostic information in critically ill adults is unknown. We prospectively studied a heterogeneous population of 451 critically ill adults, 64 (1
American Society of Nephrology.
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35. Human Tear Lipocalin Exhibits Antimicrobial Activity by Scavenging Microbial Siderophores
Human tear lipocalin (TL; also known as Lcn1) is a secretory protein present in large amounts in fluids that cover epithelial surfaces such as tears and respiratory secretions. It is supposed to act as a physiological scavenger of hydrophobic, potentially harmful molecules, but there is evidence that it also inhibits bacterial growth. In the present study, w
American Society for Microbiology.
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36. Urinary Biomarkers in the Early Detection of Acute Kidney Injury after Cardiac Surgery
Background and objectives: Serum creatinine (Scr) does not allow for early diagnosis of acute kidney injury (AKI). The diagnostic utility of urinary kidney injury molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), and neutrophil gelatinase associated lipocalin (NGAL) was evaluated for the early detection of postoperative AKI in a prospective study of 9
American Society of Nephrology.