Neuronal Apoptosis
Mostrando 13-24 de 240 artigos, teses e dissertações.
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13. Apoptosis in hypothalamic neurons from rats fed high-fat diet / Apoptose de neuronios hipotalamicos em ratos alimentados com dieta hiperlipidica
Obesity and diabetes have reached epidemic proportions in several regions of the world. General changes in life-style, including consumption of fat-rich diets, are amongst the most important factors leading to an unprecedented increase in the prevalence of these diseases. The complete characterization of the pathophysiological mechanisms leading to obesity a
Publicado em: 2009
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14. O processo inflamatório, a resposta imune "in situ" e a morte neuronal em sistema nervoso central de pacientes com raiva transmitida por morcegos / Inflammatory process, in situ immune response and neuronal death in central nervous system of patients with rabies transmitted by bats
Viral disease of central nervous system almost invariable fatal, rabies causes about 60.000 deaths yearly, and still remain a neglected disease in most countries, specially in developing ones. We study the meningeal, perivascular and parenquimal environment in central nervous system from patients who dies after bat transmitted rabies, looking for the inflamm
Publicado em: 2009
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15. Action of melatonin on neuronal death induced by sciatic nerve transection in neonatal rats / Ação da melatonina sobre a morte neuronal induzida pela secção do nervo ciatico em ratos neonatos
Morte neuronal pode ser induzida em ratos neonatos por axotomia periférica. A privação de fatores tróficos sintetizados por células alvo seria uma importante causa, pois favoreceria a ocorrência de estresse oxidativo. No presente estudo, ratos com dois dias de vida (P2) foram submetidos a secção unilateral do ciático, tratados diariamente com o anti
Publicado em: 2006
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16. "Avaliação do dano neuronal e axonal tardio, secundário ao traumatismo craniencefálico moderado e grave, por técnicas quantitativas em ressonância magnética" / Evaluation of delayed neuronal and axonal damage, secondary to moderate and severe traumatic brain injury, using quantitative magnetic resonance techniques.
Closed traumatic brain injury (TBI) is a classic model of monophasic neuronal and axonal injury, where tissue damage mainly occurs at the moment of trauma, followed by anterograde and retrograde Wallerian degeneration in the subsequent days. There are some evidences of delayed progression of the neuronal and axonal loss after TBI, mainly shown by gradual dev
Publicado em: 2005
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17. Immunohistochemical investigation of neuronal injury in cerebral cortex of cobra-envenomed rats
The immunohistochemical expression of neuron-specific enolase, NSE (a cytoplasmic glycolytic enzyme of the neurons), synaptophysin, SYN (a major membrane glycoprotein of synaptic vesicles), and Bcl-2 (anti-apoptotic protein) were determined in cerebral cortex of rats envenomed with neurotoxic venom from Egyptian cobra. Male rats were intramuscularly (IM) inj
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2004
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18. Apoptosis of sensory neurons and satellite cells after sciatic nerve transection in C57BL/6J mice
The rate of axonal regeneration, after sciatic nerve lesion in adult C57BL/6J mice, is reduced when compared to other isogenic strains. It was observed that such low regeneration was not due just to a delay, since neuronal death was observed. Two general mechanisms of cell death, apoptosis and necrosis, may be involved. By using the terminal deoxynucleotidyl
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-03
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19. Cyclin D1 is an essential mediator of apoptotic neuronal cell death.
Many neurons in the developing nervous system undergo programmed cell death, or apoptosis. However, the molecular mechanism underlying this phenomenon is largely unknown. In the present report, we present evidence that the cell cycle regulator cyclin D1 is involved in the regulation of neuronal cell death. During neuronal apoptosis, cyclin D1-dependent kinas
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20. Development of a Human Neuronal Cell Model for Human Immunodeficiency Virus (HIV)-Infected Macrophage-Induced Neurotoxicity: Apoptosis Induced by HIV Type 1 Primary Isolates and Evidence for Involvement of the Bcl-2/Bcl-xL-Sensitive Intrinsic Apoptosis Pathway
Neuronal apoptosis within the central nervous system (CNS) is a characteristic feature of AIDS dementia, and it represents a common mechanism of neuronal death induced by neurotoxins (e.g., glutamate) released from human immunodeficiency virus (HIV)-infected macrophages (HIV/macrophage-induced neurotoxicity). Neuronal apoptosis may result from activation of
American Society for Microbiology.
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21. Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection
HIV-1 infection in the brain induces neuronal apoptosis leading to HIV-associated dementia. To explore the underlying mechanism, we developed a murine model by using human peripheral blood mononuclear cell (PBMC)–transplanted nonobese diabetic (NOD)–severe combined immunodeficiency (SCID) (hu-PBMC-NOD-SCID) mice. Administration of lipopolysaccharide (LPS
The National Academy of Sciences.
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22. Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis in Human Neuronal Cells
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) causes AIDS dementia complex (ADC) in certain infected individuals. Recent studies have suggested that patients with ADC have an increased incidence of neuronal apoptosis leading to neuronal dropout. Of note, a higher level of the HIV-1 accessory protein Vpr has been de
American Society for Microbiology.
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23. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
Caspase-9 is critical for cytochrome c (cyto-c)-dependent apoptosis and normal brain development. We determined that this apical protease in the cyto-c pathway for apoptosis resides inside mitochondria in several types of cells, including cardiomyocytes and many neurons. Caspase-9 is released from isolated mitochondria on treatment with Ca2+ or Bax, stimuli
The National Academy of Sciences.
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24. Serum from patients with type 2 diabetes with neuropathy induces complement-independent, calcium-dependent apoptosis in cultured neuronal cells.
We hypothesized that sera from type 2 diabetic patients with neuropathy contains an autoimmune immunoglobulin that promotes complement-independent, calcium-dependent apoptosis in neuronal cell lines. Neuronal cells were cultured in the presence of complement-inactivated sera obtained from patients with type 2 diabetes with and without neuropathy and healthy