Neuronal Apoptosis
Mostrando 1-12 de 240 artigos, teses e dissertações.
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1. Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway
Oxiracetam (ORC) is a commonly used nootropic drug for improving cognition and memory impairments. The therapeutic effect and underlying mechanism of ORC in vascular dementia (VaD) treatment remain unknown. In this study, 3-month-old male Sprague-Dawley rats with permanent bilateral common carotid artery occlusion-induced VaD were treated orally with low (10
Braz J Med Biol Res. Publicado em: 07/11/2019
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2. A new experimental model of intrinsic denervation in ileum from wistar rats through intramural microinjections of benzalkonium chloride
RESUMO: Existe vasta literatura sobre a desnervação intrínseca de segmentos do tubo digestório através da aplicação de CB na serosa da víscera. Entretanto, essa técnica tem a desvantagem de causar peritonite, formação de bridas e alta mortalidade, não sendo factível para eventuais utilizações em humanos. O objetivo do presente estudo foi avali
Pesq. Vet. Bras.. Publicado em: 02/05/2019
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3. Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage
BACKGROUND Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS We characterized the levels of circulating cytokines, chemok
Mem. Inst. Oswaldo Cruz. Publicado em: 14/05/2018
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4. Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by expansion of the polyglutamine domain of the ataxin-3 (ATX3) protein. MJD/SCA3 is the most frequent autosomal dominant ataxia in many countries. The mechanism underlying MJD/SCA3 is thought to be mainly related to protein misfold
Braz J Med Biol Res. Publicado em: 21/11/2016
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5. Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of adult rats with ventricular fibrillation after cardiopulmonary resuscitation
OBJECTIVE: The role of Ulinastatin in neuronal injury after cardiopulmonary resuscitation has not been elucidated. We aim to evaluate the effects of Ulinastatin on inflammation, oxidation, and neuronal injury in the cerebral cortex after cardiopulmonary resuscitation. METHODS: Ventricular fibrillation was induced in 76 adult male Wistar rats for 6 min, af
Clinics. Publicado em: 2013-09
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6. Caracterização das vias de morte celular induzida pela metilecgonidina, produto da pirólise da cocaína / Neurotoxicity of anydroecgonine methyl ester, a crack cocaine pyrolysis product
A cocaína é considerada a principal droga de abuso utilizada na América do Sul, sendo que o crack é a via de administração que mais cresceu nos últimos anos. Cabe salientar que o usuário do crack sofre ação tanto da cocaína quanto das substâncias advindas da sua pirólise, dentre elas a metilecgonidina (AEME). Trabalho publicado pelo nosso grupo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/10/2012
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7. A metanandamida, um agonista canabinóide, protege a linhagem de neuroblastoma neuro2A da morte celular induzida por peróxido de hidrogênio. / The methanandamide, a cannabinoid agonist, protect the lineage of neuro 2A cell death induced by hydrogen peroxide.
Neurodegenerative diseases are progressive disorder affecting specific neuronal populations in the central nervous system, leading to neuronal death. Several factors contribute to the development of neurodegenerative diseases, including increased free radical formation and / or oxidative stress. The cannabinoid system has been suggested as an important syste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/07/2012
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8. Evaluation of the neurotoxic effects of ayahuasca tea / Avaliação dos efeitos neurotóxicos do chá ayahuasca
Ayahuasca tea is a psychotropic beverage that has caused controversy due to the fact of being used indiscriminately by some group of people and the ease of purchase in the worldweb. The tea is derived by boiling the bark of the liana Banisteriopsis Caapi (B. Caapi) together with the leaves of Psychotria Viridis (P.Viridis). B. Caapi contains alkaloids as har
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/06/2012
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9. Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock
BACKGROUND: Severe pathogenic infection triggers excessive release of cytokines as part of the massive inflammatory response associated with septic shock. OBJECTIVES: To investigate the protective effect of caffeic acid phenethye ester (CAPE) against lipopolysaccharide (LPS) induced endotoxemia, hepatic and neuronal damage and the associated systemic inflamm
Brazilian Journal of Infectious Diseases. Publicado em: 2011-08
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10. Material particulado fino presente no ar da cidade de São Paulo promove alterações nas células de Purkinje: um estudo experimental em embrião de galinha / Urban fine particles induce alterations in Purkinje cells: an experimental study in chick embryo
Air pollutants are associated to several diseases including those related to central nervous system. The aim of this work was to evaluate the effect of urban fine particles (PM2.5) in chicken embryo Purkinje cells. A single dose of PM2.5 suspension in two different concentrations (1.5 or 20.0 Pg.100Pl-1) was injected in fresh laid fertilized eggs on E0. Cont
Publicado em: 2011
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11. Development of an in vitro model of expanded ataxin-3 cytotoxic effects and evaluation of different therapeutic strategies to control of these effects / Desenvolvimento de um modelo in vitro dos efeitos citotóxicos da ataxina-3 expandida e avaliação de diferentes estratégias terapêuticas para o controle desses efeitos
Spinocerebellar ataxia-3 (SCA3), also known as Machado-Joseph disease (MJD), belongs to a group of neurodegenerative disorders caused by expansion of a polyglutamine stretch, called polyglutamine diseases. MJD is the most frequent inherited autosomal dominant ataxia in many countries. Clinical manifestations are varied, including abnormal motor coordination
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/02/2010
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12. Stem cell factor protects against neuronal apoptosis by activating AKT/ERK in diabetic mice
Neuronal apoptosis occurs in the diabetic brain due to insulin deficiency or insulin resistance, both of which reduce the expression of stem cell factor (SCF). We investigated the possible involvement of the activation of the MAPK/ERK and/or AKT pathways in neuroprotection by SCF in diabetes. Male C57/B6 mice (20-25 g) were randomly divided into four groups
Brazilian Journal of Medical and Biological Research. Publicado em: 02/10/2009