Neuroinflammation
Mostrando 1-12 de 29 artigos, teses e dissertações.
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1. Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats
RESUMO Antecedentes: A epilepsia apresenta comorbidades neuropsiquiátricas como depressão, transtorno bipolar e ansiedade. Os medicamentos que visam o tratamento da epilepsia podem ser úteis para a epilepsia e suas comorbidades neuropsiquiátricas. Objetivo: Investigar os efeitos da modulação serotonérgica em citocinas pró-inflamatórias e as convul
Arquivos de Neuro-Psiquiatria. Publicado em: 2022
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2. Effect of prednisolone on language function in children with autistic spectrum disorder: a randomized clinical trial,,
Abstract Objective: To describe the effect of prednisolone on language in children with autism spectrum disorder. This study is based upon two hypotheses: autism etiology may be closely related to neuroinflammation; and, an effective treatment should restore the individual's language skills. Method: This is a prospective, double-blinded, randomized, placeb
J. Pediatr. (Rio J.). Publicado em: 2021-02
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3. Delay of neuropathic pain sensitization after application of dexamethasone-loaded implant in sciatic nerve-injured rats
Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammatory effects induced by a dexamethasone-loaded biodegradable implant. Chronic constriction injury (CCI) of the
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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4. Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats
RESUMO OBJETIVO Nosso objetivo foi explorar os efeitos dos neuropeptídeos grelina, obestatina e peptídeo intestinal vasoativo (VIP) nas convulsões e concentrações plasmáticas de biomarcadores neuroinflamatórios, incluindo peptídeo relacionado ao gene da calcitonina (CGRP), substância-P (SP) e interleucina-1 beta (IL-1β) em convulsões induzidas p
Rev. Assoc. Med. Bras.. Publicado em: 10/10/2019
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5. Potential Therapeutic Targets of the Endocannabinoid System in Common Neurodegenerative Disorders and Organic Acidemias
Abstract The cannabinoid chemistry is currently being addressed in preclinical approaches as a viable therapeutic alternative for the management of a wide range of signs, symptoms, and some biochemical hallmarks of many neurological pathologies (such as neuroinflammation and neurodegeneration). This clinical orientation is grounded on the consistent promisso
J. inborn errors metab. screen.. Publicado em: 16/05/2019
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6. Anxiolytic properties of compounds that counteract oxidative stress, neuroinflammation, and glutamatergic dysfunction: a review
Objective: Anxiety disorders are highly prevalent and the efficacy of the available anxiolytic drugs is less than desired. Adverse effects also compromise patient quality of life and adherence to treatment. Accumulating evidence shows that the pathophysiology of anxiety and related disorders is multifactorial, involving oxidative stress, neuroinflammation,
Braz. J. Psychiatry.. Publicado em: 11/10/2018
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7. Investigação do efeito neuroprotetor da atorvastatina em um modelo in vitro de toxicidade induzida pelo peptídeo ¿-amiloide
Alzheimer¿s disease is an age-related neurodegenerative disorder characterized by progressive memory loss, inability to perform the activities of daily living and personality changes. AD is characterized histopathologically by the presence of senile plaques, neurofibrillary tangles, synapse loss and neuronal death. Moreover, it is now recognized that neuroi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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8. Estudo da ação da lovastatina no desenvolvimento do modelo experimental de epilepsia induzido pela pilocarpina em ratos / Study of lovastatin on development of experimental model of epilepsy induced by pilocarpine in rats
Introducao: A inflamacao tem sido relacionada a varias doencas neurodegenerativas e dados clinicos e experimentais sugerem uma funcao crucial nos processos inflamatorios no desenvolvimento da epilepsia, em particular, nos mecanismos geradores de crises (ictogenese) e na transformacao de uma rede neuronal normal a uma rede geradora de crises. A lovastatina, s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2011
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9. Geração de espécies reativas de oxigênio e neuroinflamação induzidas por enucleação ocular no sistema visual de ratos. / Reactive oxygen species generation and neuroinflammation induced by ocular enucleation in the rat visual system.
O modelo de enucleação ocular em roedores é frequentemente empregado para o estudo dos efeitos da desaferentação de estruturas retinorrecipientes. Avaliamos a geração de espécies reativas de oxigênio (EROs), no colículo superior (CS) e núcleo geniculado lateral dorsal do tálamo (GLD) após enucleação ocular. A oxidação da dihidroetidina revel
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2011
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10. Report of cases in patients with acute herpetic neuralgia using a Mangifera indica extract
It has been accepted that neuroinflammation, oxidative stress and glial activation are involved in the central sensitization underlying neuropathic and inflammatory pain. Vimang® is the brand name of an aqueous extract of Mangifera indica L., Anacardiaceae, traditionally used in Cuba for its antioxidant, antiinflammatory, analgesic, and immunomodulatory pro
Revista Brasileira de Farmacognosia. Publicado em: 08/07/2011
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11. Stress-induced neuroinflammation: mechanisms and new pharmacological targets
Stress is triggered by numerous unexpected environmental, social or pathological stimuli occurring during the life of animals, including humans, which determine changes in all of their systems. Although acute stress is essential for survival, chronic, long-lasting stress can be detrimental. In this review, we present data supporting the hypothesis that stres
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-12
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12. Participação do oxido nitrico no desenvolvimento da encefalomielite alergica experimental em ratos
Nitric oxide (NO) is a free radical endogenously synthetised by oxidation of one of the guanidinum nitrogen atoms of the aminoacid L-arginine by molecular oxygen. This biosynthesis is catalised by a family of enzimes generically known as nitric oxide synthases (NOS), which can be inhibited by structural analogs of L-arginine having substituent groups at the
Publicado em: 2001