Neuroendocrine Cells
Mostrando 13-24 de 237 artigos, teses e dissertações.
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13. Histologia, imunohistoquimica e ultra-estrutura do epitelio da uretra pelvica e peniana nas linhagens de ratos albinos UChA e UChB, bebedoras voluntarias de etanol
The extreme use of ethanol causes significant alterations in the urogenital tract, however papers relating the ethanol chronic consumption to the urethral morphology are unknown. The objective of the present paper was to describe the histology, histochemistry, immunohistochemistry and ultrastructure of the urethral epithelium in an ethanol-drinking rat strai
Publicado em: 2004
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14. Aspectos anátomo-histológicos e neuroendócrinos do ceco da capivara Hydrochoerus hydrochaeris Linnaeus, 1766 (Mammalia, Rodentia) / Anatomohistological and neuroendocrine aspects of cecum of the capybara Hydrochoerus hydrochaeris Linnaeus, 1766 (Mammalia, Rodentia)
A capivara, um roedor herbívoro de estômago simples, vem sendo apontada no mercado de carnes por ter um excelente desempenho zootécnico. Sua carne é apreciada e sua carcaça valiosa, apresenta elevado potencial reprodutivo e manifesta eficiente aproveitamento dos alimentos. Este, provavelmente seja conseqüência da realização da cecotrofia, que faz do
Publicado em: 2003
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15. The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics
Cytokines are molecules that were initially discovered in the immune system as mediators of communication between various types of immune cells. However, it soon became evident that cytokines exert profound effects on key functions of the central nervous system, such as food intake, fever, neuroendocrine regulation, long-term potentiation, and behavior. In t
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-10
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16. Depletion of neuroendocrine cells in rectal biopsy specimens from HIV positive patients.
AIMS: To compare the density of neuroendocrine cells in rectal biopsy specimens from human immunodeficiency virus (HIV) infected individuals with that of a control group. METHODS: Neuroendocrine cells in rectal biopsies were identified using an immunohistochemical stain for chromogranin and subsequently quantified using a method of linear intercept. RESULTS:
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17. Appropriate and inappropriate neuroendocrine products in pulmonary tumourlets.
Pulmonary tumourlets are focal aggregates of neuroendocrine cells that occur in the periphery of the lung and may be associated with chronic inflammation and scarring. Six such lesions were seen in five lungs from a series of 35 pairs of lungs studied at necropsy. All were immunoreactive for neurone-specific enolase, protein gene product 9.5, and a range of
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18. Cell type-specific gene expression in the neuroendocrine system. A neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein.
The acidic secretory protein chromogranin A universally occurs in amine and peptide hormone and neurotransmitter storage granules throughout the neuroendocrine system. What factors govern the activity of the chromogranin A gene, to yield such a widespread yet neuroendocrine-selective pattern of expression? To address this question, we isolated the mouse chro
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19. Synaptophysin: a marker protein for neuroendocrine cells and neoplasms.
Synaptophysin is an integral membrane glycoprotein (Mr 38,000) that occurs in presynaptic vesicles of neurons and in similar vesicles of the adrenal medulla. By using a monoclonal antibody to this protein (SY38), we have found, by immunohistochemistry and immunoblotting, that an identical or similar protein is also expressed in neuroendocrine tumors of neura
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20. Insertion of the v-Ha-ras oncogene induces differentiation of calcitonin-producing human small cell lung cancer.
Human small cell lung cancers (SCLC) and cell lines derived therefrom are phenotypically heterogeneous concerning neuroendocrine differentiation. Unlike most SCLC tumors and cell lines that express poorly differentiated neuroendocrine phenotypes, the SCLC cell line DMS 53 exhibits mature endocrine differentiation features, including unusually high expression
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21. Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma.
Cigarette smoking is associated with hyperplasia of pulmonary neuroendocrine cells and variably increased levels of bombesin-like peptides in the lower respiratory tract. Because the neuropeptide bombesin is a chemoattractant for monocytes and a mitogen for 3T3 fibroblasts, we hypothesized that an excess of neuroendocrine cells and bombesin-like peptides cou
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22. A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A.
Chromogranin A, a soluble acidic protein, is a ubiquitous component of secretory vesicles throughout the neuroendocrine system. We reported previously the cloning and initial characterization of the mouse chromogranin A gene promoter, which showed that the promoter contains both positive and negative domains and that a proximal promoter spanning nucleotides
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23. A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells
A transgenic mouse model of metastatic prostate cancer has been developed that is 100% penetrant in multiple pedigrees. Nucleotides −6500 to +34 of the mouse cryptdin-2 gene were used to direct expression of simian virus 40 T antigen to a subset of neuroendocrine cells in all lobes of the FVB/N mouse prostate. Transgene expression is initiated between 7 an
The National Academy of Sciences.
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24. Changes in neuroendocrine elements in bronchial mucosa in chronic lung disease in adults.
BACKGROUND--It is not clear whether there is any association between metaplasia of the bronchial epithelium and changes in the distribution of neuroendocrine cells. This study examined, by immunohistological techniques, the distribution of neuroendocrine cells and juxtamucoscal nerve fibres in bronchial biopsies showing metaplastic changes. METHODS--Bronchia