Neural Degeneration
Mostrando 13-24 de 54 artigos, teses e dissertações.
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13. Mutations in the Novel Membrane Protein Spinster Interfere with Programmed Cell Death and Cause Neural Degeneration in Drosophila melanogaster
Mutations in the spin gene are characterized by an extraordinarily strong rejection behavior of female flies in response to male courtship. They are also accompanied by decreases in the viability, adult life span, and oviposition rate of the flies. In spin mutants, some oocytes and adult neural cells undergo degeneration, which is preceded by reductions in p
American Society for Microbiology.
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14. “Global” cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain
Many diseases of the central nervous system (CNS), particularly those of genetic, metabolic, or infectious/inflammatory etiology, are characterized by “global” neural degeneration or dysfunction. Therapy might require widespread neural cell replacement, a challenge not regarded conventionally as amenable to neural transplantation. Mouse mutants character
The National Academy of Sciences.
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15. VEGF: a critical player in neurodegeneration
VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEG
American Society for Clinical Investigation.
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16. The aetiology of mirror writing: a new hypothesis.
Twenty-eight cases of mirror writing were seen during a period of three and a half years. These consisted of 12 patients with essential tremor, nine with Parkinson's disease, three with spino-cerebellar degeneration and four other cases. There were no cases of hemiparesis, aphasia, apraxia, agnosia or confusion. Fragmentary reversals were excluded from this
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17. Cytosol-endoplasmic reticulum interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila
Intracellular deposition of aggregated and ubiquitinated proteins is a prominent cytopathological feature of most neurodegenerative disorders frequently correlated with neural cell death. To elucidate mechanisms in neural cell death and degeneration, we characterized the Drosophila ortholog of Sec61α (DSec61α), a component of the translocon that is involve
National Academy of Sciences.
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18. Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity.
The low-affinity nerve growth factor receptor (NGFR) p75NGFR induces apoptosis in the absence of nerve growth factor (NGF) binding but enhances neural survival when bound by NGF. Basal forebrain cholinergic neurons express the highest levels of p75NGFR in the adult human brain and are preferentially involved in Alzheimer disease, raising the question of whet
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19. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.
The immunosuppressant drug FK506 acts by binding to receptor proteins, FK506-binding proteins (FKBPs), which in turn can bind to and regulate a Ca(2+)-dependent phosphatase, calcineurin, and a Ca2+ release channel, the ryanodine receptor. Based on our findings in regeneration models that levels of FKBPs during neural regeneration parallel those of growth-ass
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20. Some observations about retinal vascular-neuronal interrelationships.
The relationship between the intraretinal vessels of the human fundus and the surrounding neuronal tissue is discussed with regard to various disease states. Present evidence suggests that primary retinal neuronal death does not lead to secondary retinal capillary death. Primary retinal capillary non-perfusion generally leads to concomitant retinal neuronal
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21. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.
This study determined whether retinal degeneration during diabetes includes retinal neural cell apoptosis. Image analysis of retinal sections from streptozotocin (STZ) diabetic rats after 7.5 months of STZ diabetes identified 22% and 14% reductions in the thickness of the inner plexiform and inner nuclear layers, respectively (P < 0. 001). The number of surv
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22. The origin of the neural macrophage: a quantitative ultrastructural study of cell population changes during Wallerian degeneration.
The changes that follow a localised crush injury to the rat sural nerve have been used to study endoneurial populations during Wallerian degeneration. The removal of products of degeneration, and in particular myelin debris, is accomplished by globule-laden cells which appear in the endoneurium during the first few days of repair. The origin of these cells h
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23. The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older individuals worldwide. The disease is characterized by abnormal extracellular deposits, known as drusen, that accumulate along the basal surface of the retinal pigmented epithelium. Although drusen deposition is common in older individuals, large numbers of drusen
The National Academy of Sciences.
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24. The transcription factor Sox10 is a key regulator of peripheral glial development
The molecular mechanisms that determine glial cell fate in the vertebrate nervous system have not been elucidated. Peripheral glial cells differentiate from pluripotent neural crest cells. We show here that the transcription factor Sox10 is a key regulator in differentiation of peripheral glial cells. In mice that carry a spontaneous or a targeted mutation o
Cold Spring Harbor Laboratory Press.