Nephrotoxicity
Mostrando 13-24 de 269 artigos, teses e dissertações.
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13. Hepatotoxicity and nephrotoxicity of 3-bromopyruvate in mice
ABSTRACT PURPOSE: To investigate the hepatotoxicity and nephrotoxicity of 3-Bromopyruvate (3BP) in mice. METHODS: Fifteen nude mice were grafted subcutaneously in the left flank with MDA-MB-231 cells, then all mice were divided into control group (PBS), 3BP group (8 mg/kg), positive group (DNR: 0.8 mg/kg) when tumor volume reached approximately 100 mm3. 28
Acta Cir. Bras.. Publicado em: 2016-11
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14. The effect of the carotenoid bixin and annatto seeds on hematological markers and nephrotoxicity in rats subjected to chronic treatment with cisplatin
ABSTRACT This study assessed the protective effect of the carotenoid bixin and annatto seeds against possible nephrotoxicity induced with a single peritoneal administration of pharmacological cisplatin in male Wistar rats. After 48 h, the blood cell differential count showed a significant reduction in neutrophil counts in rats that received a diet rich in bi
Rev. bras. farmacogn.. Publicado em: 2016-08
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15. A New Steroidal Saponin from the Tubers of Ophiopogon japonicus and Its Protective Effect Against Cisplatin-Induced Renal Cell Toxicity
A new furostanol saponin, ophiopogonin T, was isolated from the tubers of Ophiopogon japonicus. Its structure was established by extensive spectroscopic techniques including 1D (1H and 13C) and 2D nuclear magnetic resonance (NMR) experiments (correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlati
J. Braz. Chem. Soc.. Publicado em: 2016-04
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16. Nephrotoxicity during tenofovir treatment: a three-year follow-up study in a Brazilian reference clinic
Abstract In this study, 275 patients in use of tenofovir were retrospectively followed-up for three years to evaluate risk factors involved in impaired renal function. Analysis of variance (ANOVA) and Tukey's test were used to verify any differences in creatinine levels and estimated clearance at 0, 6, 12, 24 and 36 months, adjusting for the co-variables sex
Braz J Infect Dis. Publicado em: 2016-02
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17. Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications
ABSTRACTCarthami flos, the dried floret of Carthamus tinctorius L., Asteraceae (safflower), has been widely used in traditional Chinese medicine to treat a broad range of ailments, such as coronary heart disease, angina pectoris, gynecologic disease, stroke, and hypertension. However, although several studies on Carthami flos have been done consecutively, th
Rev. bras. farmacogn.. Publicado em: 2015-10
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18. Urine alpha1-microglobulin is a better marker for early tubular dysfunction than beta2-microglobulin among tenofovir-exposed human immunodeficiency virus-infected men who have sex with men
Objectives: Men who have sex with men are at risk of tenofovir nephrotoxicity due to its wide use in both treatment and prophylaxis for human immunodeficiency virus infection, but little is known about the urinary biomarkers of early renal dysfunction in this population. This study aims to identify useful biomarkers of early renal dysfunction among human im
Braz J Infect Dis. Publicado em: 2015-08
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19. Efficacy of polymyxins in the treatment of carbapenem-resistant Enterobacteriaceae infections: a systematic review and meta-analysis
In recent years, carbapenem-resistant Enterobacteriaceae has become endemic in many countries. Because of limited treatment options, the abandoned "old antibiotics", polymyxins, have been reintroduced to the clinic. To evaluate the clinical efficacy of polymyxins in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae , we systemica
Braz J Infect Dis. Publicado em: 2015-04
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20. Effects of immunosuppression with tacrolimus and mycophenolate mofetil on renal histology and function in single kidney rats submitted to ischemia and reperfusion
PURPOSE: To evaluate renal histological changes and renal function in single kidney rats submitted to renal ischemia-reperfusion and to immunosuppression with tacrolimus and mycophenolate-mofetil. METHODS: Experimental study with 80 Wistar rats distributed into control, Sham and six other groups treated with immunosuppressive drugs. Animals undergoing surge
Acta Cir. Bras.. Publicado em: 2015-02
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21. Influence of cyclosporine on the occurrence of nephrotoxicity after allogeneic hematopoietic stem cell transplantation: a systematic review
Cyclosporine, a drug used in immunosuppression protocols for hematopoietic stem cell transplantation that has a narrow therapeutic index, may cause various adverse reactions, including nephrotoxicity. This has a direct clinical impact on the patient. This study aims to summarize available evidence in the scientific literature on the use of cyclosporine in re
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-10
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22. Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats
Purpose To demonstrate the effect of a 4% pulverized garlic supplemented diet on the nephrotoxicity induced by gentamicin in rats. Materials and Methods Twenty four healthy male Wistar rats, weighing between 220 - 260grams, were divided into three groups. The rats were randomly assigned to either the gentamicin injection without garlic supplementation g
Int. braz j urol.. Publicado em: 2014-08
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23. Efeito protetor da N-Acetilcisteína sobre a nefrotoxicidade de meios de contraste baseados no gadolínio em modelo experimental de doença renal crônica / Protective effect of N-acetylcysteine on the nephrotoxicity of contrast media based on gadolinium in an experimental model of chronic kidney disease
INTRODUÇÃO: O Gadolínio (Gd) é um raro metal da classe dos lantanídios usado como meio de contraste devido as suas propriedades paramagnéticas. Após sua descoberta, foi considerado um contraste pouco nefrotóxico em pacientes com doença renal crônica (DRC). Atualmente, existem evidências de que o Gd pode apresentar nefrotoxicidade semelhante aos co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/03/2012
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24. Efeito do cigarro na nefrotoxicidade crônica causada pela Ciclosporina A em ratos.
A nefrotoxicidade crônica induzida pela ciclosporina A (CsA) é caracterizada por disfunção renal e fibrose tubulointersticial irreversível. Associado ao uso da CsA, o hábito de fumar é um fator de risco que reduz a taxa de filtração glomerular, aumenta a resistência vascular renal, deteriora a função renal e causa alterações morfológicas como
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/01/2012