Natriuresis
Mostrando 1-12 de 157 artigos, teses e dissertações.
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1. SGLT-2 inhibitors in diabetes: a focus on renoprotection
SUMMARY Type 2 diabetes mellitus is an important public health problem, with a significant impact on cardiovascular morbidity and mortality and an important risk factor for chronic kidney disease. Various hypoglycemic therapies have proved to be beneficial to clinical outcomes, while others have failed to provide an improvement in cardiovascular and renal fa
Rev. Assoc. Med. Bras.. Publicado em: 13/01/2020
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2. Fluid volume kinetics of dilutional hyponatremia; a shock syndrome revisited
OBJECTIVE: To evaluate whether the pathophysiology of shock syndromes can be better understood by comparing central hemodynamics with kinetic data on fluid and electrolyte shifts. METHODS: We studied the dilutional hyponatremic shock that developed in response to overhydration with electrolyte-free irrigating fluid - the so-called ‘transurethral resecti
Clinics. Publicado em: 2014-02
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3. Estudo dos efeitos da alta ingestÃo de cloreto de sÃdio por via oral sobre o metabolismo diÃrio e funÃÃo renal de ratos. / Study of effects on the daily metabolism and the renal function of rats under high oral ingestion of sodium chloride.
Guanylin (GN), uroguanylin (UGN), and the bacterial heat-stable enterotoxin (ST) peptides comprise a new family of cyclic guanosine 3â-5â monophosphate (cGMP)-regulating agonist. Ingestion of a salt meal induces secretion of GN and UGN into the intestinal lumen, where they inhibit Na+ absorption and induces Cl-, HCO3- , and water secretion. Simultaneously,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/01/2009
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4. Consequences of cerebroventricular insulin injection on renal sodium handling in rats: effect of inhibition of central nitric oxide synthase
In the present study, we investigated the effects of acute intracerebroventricular (icv) insulin administration on central mechanisms regulating urinary sodium excretion in simultaneously centrally NG-nitro-L-arginine methylester (L-NAME)-injected unanesthetized rats. Male Wistar-Hannover rats were randomly assigned to one of five groups: a) icv 0.15 M NaCl-
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-12
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5. Long-term exercise training attenuates arterial blood pressure responsiveness and modulates angiotensina II signal transduction and urinary sodium excretion in SHR / Avaliação da pressão arterial e da excreção renal de sodio em animais espontaneamente hipertensos (SHR) submetidos a atividade fisica programada : participação dos receptores AT1R e AT2R da angiotensina II em rins
A hipertensão arterial é um dos principais fatores de risco para a alta morbidade e mortalidade cardiovascular. A prevalência mundial é estimada em 1 bilhão de indivíduos. No Brasil estima-se que essa prevalência esteja entre 20 a 44% da população, sendo 17 milhões de brasileiros portadores da patologia, acarretando um custo anual de 11 bilhões de
Publicado em: 2009
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6. Expressão de supressor de sinalização de citocina (SOCS-3) em hipotalamo de rato espontaneamente hipertenso : efeito sobre a excreção renal de sodio induzida pela Angiotensina II / Expression of supressor of cytokine signaling (SOCS-3) in spontaneous hypertensive rat hypothalamus : effect on renal sodium excretion induced by angiotensin II
There is a surprising lack of experimental data on the renal sodium handle mechanisms induced by i.c.v injection of AngII in hypertensive animals. Thus, we hypothesized that a presumable blunted response to centrally injected AngII may contribute to sodium metabolism disturbances observed in SHR. The study was performed after acute i.c.v AngII administration
Publicado em: 2008
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7. Matching salt intake to physiological need in rats using foraging protocols
Several studies of the quantitative relationship between sodium need and sodium intake in rats are reviewed. Using acute diuretic treatment 24 h beforehand, intake matches need fairly accurately when intake is spread out in time by using a hypotonic solution of NaCl. In contrast, using a hypertonic solution, intake is typically double the need. Using the sam
Brazilian Journal of Medical and Biological Research. Publicado em: 14/03/2007
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8. Effective of intracerebroventricular insulin microinjection on renal sodium handling in spontaneous hypertensive rats / Efeito da administração intracerebroventricular de insulina sobre a excreção urinaria de sodio e vias de sinalização da insulina em hipotalamo de ratos hipertensos
Evidências recentes demonstram uma estreita correlação entre situações de resistência ao efeito hipoglicemiante da insulina e conseqüente hiperinsulinemia, e hipertensão arterial sistêmica. Especula-se que a insulina possa desempenhar um papel no desenvolvimento ou manutenção da hipertensão arterial. Embora autores demonstrem que a administraçã
Publicado em: 2007
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9. Envolvimento dos receptores AT1 e do óxido nítrico na ingestão de NaCl 0,5 M e nas respostas dipsogênicas, renais e pressoras produzidas pela angiotensina II injetada na área septal lateral.
In this study, we investigated the participation of the AT1 receptors and of the nitric oxide (NO) into lateral septal area (LSA), on the water intake, 0,5 M NaCl intake, natriuresis, diuresis and pressor response induced by injection of angiotensin II (ANG II) in the same area. Male Holtzman rats were used weighing between 280 and 320 g, with cannulae of st
Publicado em: 2006
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10. Avaliação da atividade fisica sobre a pressão arterial e a função renal em ratos espontaneamente hipertensos (SHR) / Effects of physical activity upon arterial blood pressure and the function in spontaneously rats (SHR)
A vinculação entre os níveis de atividade física e a elevação pressórica tem sido aventada. No entanto, os mecanismos fisiopatológicos envolvidos nesta modificação da pressão arterial são pouco conhecidos e estudados. O presente estudo tem como objetivo avaliar o efeito da atividade física aeróbia sobre a pressão arterial, a filtração glomer
Publicado em: 2006
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11. Estudo da filtração glomerular e da manipulação tubular renal de sodio em animais normotensos e hipertensos submetidos a injeção intracerebroventricular de solução salina hipertonica : influencia da denervação renal bilateral
The mechanism by which blood pressure has risen in the spontaneously hypertensive rats (SHR) strain remains to be elucidated. Besides, there is a surprising lack of experimental data on the natriuretic mechanisms induced by intracerebroventricular (i.c.v.) injection of hypertonic saline in SHR. In the current study, we have hypothesized that SHR hypertension
Publicado em: 2005
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12. Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides
Chronic stimulation of sympathetic nervous activity contributes to the development and maintenance of hypertension, leading to left ventricular hypertrophy (LVH), arrhythmias and cardiac death. Moxonidine, an imidazoline antihypertensive compound that preferentially activates imidazoline receptors in brainstem rostroventrolateral medulla, suppresses sympathe
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-08