Nasal Immunization
Mostrando 1-12 de 100 artigos, teses e dissertações.
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1. Nasal immunization with outer membrane antigens of Neisseria meningitidis B selected for the highest expression of the immunotype of LPS 3,7,9 with monoclonal antibodies and Bordetella pertussis as adjuvants in neonates mice. / Imunização nasal com antígenos de membrana externa de Neisseria meningitidis B selecionados para a maior expressão do imunotipo de LPS 3, 7, 9 com anticorpos monoclonais e Bordetella pertussis como adjuvante em camundongos neonatos.
The natural habitat of Neisseria meningitidis is the human nasopharynx, and the bacterium is transmitted by direct mouth-to-mouth contact or by the inhalation of released mucous particles during close contact. N meningitidis is a Gram-negative bacterium responsible for significant mortality worldwide. While effective polysaccharide-based vaccines exist again
Publicado em: 2008
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2. Estudo da imunogenicidade da proteína de classe 3 (PorB) purificada da membrana externa de Neisseria miningitidis: imunização intranasal/intramuscular em camundongos adultos e neonatos utilizando Bordetella pertussis como adjuvante. / Study of the immunogenecity of the class 3 proteins (PorB) purified from the outer mebrane of Neisseria meningitidis: intranasal and intramuscular immunization in adult and neonate mice using Bordetella pertussis as adjuvant.
Proteins of class 3 sound candidates in the preparation of vaccine against meningococcal illness. The aim of this study was to determine the immunogenicity of class 3 proteins purified of Neisseria meningitidis of the serogroup B along with whole cells of Bordetella pertussis as adjuvant. BALB/c and outbred neonate mice between 3 and 12 days old were immuniz
Publicado em: 2008
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3. Patterns of influenza infections among different risk groups in Brazil
Influenza virus infections are associated with high morbidity and mortality. Influenza activity varies worldwide, and regional detection is influenced by geographic conditions, demographic and patient-risk factors. We assessed influenza activity and patterns of seasonality during three consecutive years (2001-2003) in three risk groups in São Paulo city. Fo
Brazilian Journal of Infectious Diseases. Publicado em: 2007-08
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4. Adjuvant requirement for successful immunization with recombinant derivatives of Plasmodium vivax merozoite surface protein-1 delivered via the intranasal route
Recently, we generated two bacterial recombinant proteins expressing 89 amino acids of the C-terminal domain of the Plasmodium vivax merozoite surface protein-1 and the hexa-histidine tag (His6MSP1(19)). One of these recombinant proteins contained also the amino acid sequence of the universal pan allelic T-cell epitope (His6MSP1(19)-PADRE). In the present st
Memórias do Instituto Oswaldo Cruz. Publicado em: 10/05/2007
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5. Collagen V- induced nasal tolerance in scleroderma experimental model / Indução de tolerância nasal com colágeno tipo V em modelo experimental de esclerodermia
Objective: Our aim was to verify the skin remodeling and antibody production in experimental model of scleroderma in rabbits, after induction of tolerance by daily nasal administration of human type V collagen (Col V). Methods: Female New Zealand rabbits (N=12) were immunized with 1mg/ml of Col V in complete Freunds adjuvant, followed by more two boosters in
Publicado em: 2007
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6. Morphometric study of immune cellular and pre-acinar axis remodeling by type V collagen induction on bronchiolite obliterans model / Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante
A minority of patients with remodeling process of lungs following bronquiolite obliterante (BO) responds to corticosteroids. So, we sought to validate the importance of type V collagen (tVc) tolerance from immunization as option in BO model treatment. Througt of morphometric analyses, we have mensured for the dimensions, the collagen and cell infiltration de
Publicado em: 2007
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7. Proteção imunológica contra a formação de cistos cerebrais em camundongos vacinados pela via nasal com proteínas recombinates de Toxoplasma gondii
Toxoplasma gondii is a protozoan parasite which can invade and reside in a wide range of host cells. It can infect all warm-blooded animals, including human being. Parasite invasion is associated with protein secretion from three organelles: micronemes, rhoptries and dense granules. These excreted/secreted antigens were highly immunogenic in humans and roden
Publicado em: 2006
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8. Immunoglobulin A (IgA) Responses and IgE-Associated Inflammation along the Respiratory Tract after Mucosal but Not Systemic Immunization
The purpose of the present study was to determine the extent of immunologic responses, particularly immunopathologic responses, within the upper and lower respiratory tracts after intranasal immunization using the mucosal adjuvant cholera toxin (CT). BALB/c mice were nasally immunized with influenza virus vaccine combined with CT. The inclusion of the mucosa
American Society for Microbiology.
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9. Rubella Immunization of Volunteers Via the Respiratory Tract
The efficacy of various routes of administration of the live attenuated rubella virus vaccine was evaluated by using 46 seronegative volunteers who were divided into 4 vaccine groups: subcutaneous, nosedrops, spray into posterior oropharynx and nose using large particle aerosol, and inhalation of small particle aerosol through the mouth. Seroconversion was o
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10. Mucosally Induced Immunoglobulin E-Associated Inflammation in the Respiratory Tract
The purpose of the present study was to determine the immunologic responses, particularly immunopathologic reactions, associated with nasal immunization with the mucosal adjuvant, cholera toxin (CT). BALB/c mice were nasally immunized with tetanus toxoid (TT) combined with CT, and the responses of these mice were determined. After nasal immunization, mice pr
American Society for Microbiology.
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11. Antibody Responses in the Lower Respiratory Tract and Male Urogenital Tract in Humans after Nasal and Oral Vaccination with Cholera Toxin B Subunit
Nasal vaccine delivery is superior to oral delivery in inducing specific immunoglobulin A (IgA) and IgG antibody responses in the upper respiratory tract. Although an antibody response in the nasal passages is important in protecting against primary colonization with lung pathogens, antibodies in the lungs are usually required as well. We immunized 15 male v
American Society for Microbiology.
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12. Mucosal but Not Parenteral Immunization with Purified Human Papillomavirus Type 16 Virus-Like Particles Induces Neutralizing Titers of Antibodies throughout the Estrous Cycle of Mice
We have recently shown that nasal immunization of anesthetized mice with human papillomavirus type 16 (HPV16) virus-like particles (VLPs) is highly effective at inducing both neutralizing immunoglobulin A (IgA) and IgG in genital secretions, while parenteral immunization induced only neutralizing IgG. Our data also demonstrated that both isotypes are similar
American Society for Microbiology.