Nanocarriers
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. ABRINDO A CAIXA DE PANDORA DOS NANOMEDICAMENTOS: HÁ REALMENTE MUITO MAIS ‘ESPAÇO LÁ EMBAIXO’
Limitations of conventional treatment and dosage forms prompted the investigation of novel approaches that combine efficacy, selectivity and fewer adverse effects. These are the main promises of nanomedicine, generally defined as the application of nanotechnology to the biomedical field. Despite the considerable advances over the years and the large number o
Quím. Nova. Publicado em: 2020-02
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2. Colombian propolis as starting material for the preparation of nanostructured lipid carriers
ABSTRACT The value of propolis is scientifically and commercially measured through the content of biologically active molecules as phenolic compounds and flavonoids; on the other hand, a high percentage of waxes in the propolis composition makes it a substandard beekeeping product. Colombian propolis is characterized by a high content of waxes; however, this
Rev. bras. farmacogn.. Publicado em: 26/08/2019
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3. Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; physicochemical properties, in vitro release and oral acute toxicity
Inorganic and carbon based nanomaterials are widely used against several diseases, such as cancer, autoimmune diseases as well as fungi and bacteria colonization. In this work, Santa Barbara Amorphous mesoporous silica (SBA), Halloysite Nanotubes (HNTs) and Multiwalled Carbon Nanotubes (CNTs) were loaded with fluoroquinolone Levofloxacin (LVF) to be applied
Braz. J. Pharm. Sci.. Publicado em: 12/08/2019
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4. Synthesis of Highly Ordered Mesoporous MCM-41: Selective External Functionalization by Time Control
Sol-gel synthesis is commonly used to modify the surface of mesoporous silica nanoparticles (MSN) with organic groups through the co-condensation method. The template removal, and the site-controlled addition of organic groups and their partial occlusion inside the framework walls are still a challenge in the one-pot synthesis. Here, we optimize the synthesi
J. Braz. Chem. Soc.. Publicado em: 12/08/2019
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5. Process Evaluation of Sugar-Based Polymeric Colloidal Nanocarrier Formation
Abstract Several studies have demonstrated that sugar-based nanocarriers are recommended to develop drug delivery systems since they are biocompatible and biodegradable and might improve the therapeutic index of currently used drugs by reducing their toxicity and enhancing their bioavailability. Therewith, this work studied the processing conditions to forma
Mat. Res.. Publicado em: 31/01/2019
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6. Development and validation of stability indicating liquid chromatographic (RP-HPLC) method for estimation of ubidecarenone in bulk drug and formulations using quality by design (QBD) approach
ABSTRACT A novel, accurate, precise and economical stability indicating Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method, was developed and validated for the quantitative determination of ubidecarenone (UDC) in bulk drug, UDC marketed formulation and UDC loaded cubosomes (CBMs) nanocarriers through Response surface methodology (RSM) desi
Braz. J. Pharm. Sci.. Publicado em: 05/03/2018
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7. An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy
ABSTRACT Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In
An. Acad. Bras. Ciênc.. Publicado em: 2018
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8. Validation of a Chromatographic Analytical Method for Quantification of Benznidazole Incorporated in Nanostructured Lipid Formulations
Benznidazole (BNZ) has been employed in the treatment of Chagas disease; however, its low water solubility is a drawback, which can be overcome by incorporating BZN within nanostructured systems. The aim of this work was to validate a chromatographic method for determination of BZN incorporated in nanoemulsions (NE) and nanostructured lipid carriers (NLC). T
J. Braz. Chem. Soc.. Publicado em: 2017-02
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9. Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery
ABSTRACT Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The nanocapsules were prepared using the interfacial deposition
Braz. J. Pharm. Sci.. Publicado em: 2016-12
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10. Liposome and Their Applications in Cancer Therapy
ABSTRACT Liposomes, the vesicles of phospholipid bilayer, can encapsulate both hydrophilic and lipophilic drugs and protect them from degradation. Liposomes have been extensively studied and continue to create intense interest in research since their discovery in the mid-1960s. Since then, liposomes have been considered to be the most successful nanocarriers
Braz. arch. biol. technol.. Publicado em: 08/03/2016
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11. Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation
Abstract Pluronics® molecules self-assemble in aqueous solution providing a core/shell architecture that improves the solubility of hydrophobic drugs. Binary mixtures of Pluronics® have been studied as drug nanocarriers in order to combine their advantages, like high colloidal stability, small particle size and good solubilisation capacity (Scp). In this w
Polímeros. Publicado em: 2015-10
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12. Estudo de sistemas nanocarreadores para o ácido 5-aminolevulínico com aplicação na terapia fotodinâmica / Study of nanocarriers systems to 5-aminolevulinic acid for photodynamic therapy use
O ácido 5-aminolevulínico (5-ALA) é empregado como pró-fármaco, precursor de um agente fotossensibilizador na terapia fotodinâmica (TFD). Após a aplicação de 5-ALA topicamente, a incidência de luz visível de comprimento de onda apropriado induz a formação de uma substância altamente fluorescente e fotodinamicamente ativa, a Protoporfirina IX (P
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/05/2012