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Mostrando 13-24 de 998 artigos, teses e dissertações.
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13. An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy
Abstract Purpose: To compare the preventive effects of N-acetyl cysteine (NAC), ozone preconditioning and ozone treatment against contrast-induced nephropathy (CIN) in an experimental rat model. Methods: Thirty adult male Wistar rats were randomly distributed into five groups (n=6 for each group). Group I served as control and Group II had only contrast a
Acta Cir. Bras.. Publicado em: 2018-06
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14. Efeito da suplementação de antioxidantes sobre o limiar auditivo na perda auditiva neurosensorial: uma metanálise
Resumo Introdução: A perda auditiva é conceituada como qualquer diminuição da capacidade de ouvir e/ou detectar sons da fala ou do ambiente, independentemente da causa, tipo ou grau e pode ocorrer em diversos estágios da vida, durante a gestação ou parto, na infância, vida adulta ou na terceira idade. Convém destacar que o envelhecimento é a prim
Braz. j. otorhinolaryngol.. Publicado em: 2018-06
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15. Selenium, Vitamin C and N-Acetylcysteine do not Reduce the Risk of Acute Kidney Injury after Off-Pump CABG: a Randomized Clinical Trial
Abstract Objective: The aim of this study was to investigate the impact of perioperative administration of N-acetylcysteine, selenium and vitamin C on the incidence and outcomes of acute kidney injury after off-pump coronary bypass graft surgery. Methods: 291 patients requiring elective off-pump coronary bypass graft surgery were randomized to receive eith
Braz. J. Cardiovasc. Surg.. Publicado em: 2018-04
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16. Removal and killing of multispecies endodontic biofilms by N-acetylcysteine
ABSTRACT Removal of bacterial biofilm from the root canal system is essential for the management of endodontic disease. Here we evaluated the antibacterial effect of N-acetylcysteine (NAC), a potent antioxidant and mucolytic agent, against mature multispecies endodontic biofilms consisting of Actinomyces naeslundii, Lactobacillus salivarius, Streptococcus mu
Braz. J. Microbiol.. Publicado em: 2018-03
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17. N-Acetyl-cysteine Increases Chemical Stability of Hydroquinone in Pharmaceutical Formulations: a Theoretical and Experimental Approach
In this study, the chemistry stability of hydroquinone (HQ) was evaluated according to its effects in redox properties and compared to kojic acid (KA). The HQ oxidation was more inhibited by N-acetylcysteine (NAC) than ascorbic acid (AA). These results were elucidated using theoretical methods at the DFT/B3LYP level of theory. All electronic parameters were
J. Braz. Chem. Soc.. Publicado em: 2018-03
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18. Effects of N-acetylcysteine on amphetamine-induced sensitization in mice
Objective: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled in rodents by repeated exposure to psychostimulants, provoking an enduring amplified response at subsequ
Rev. Bras. Psiquiatr.. Publicado em: 11/12/2017
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19. Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-
Braz J Med Biol Res. Publicado em: 19/10/2017
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20. Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain
N-acetylcysteine (NAC) inhibits nociceptive transmission. This effect has been associated partly with its antioxidant properties. However, the effect of NAC on the levels of lipid hydroperoxides (a pro-oxidant marker), content of ascorbic acid (a key antioxidant molecule of nervous tissue) and total antioxidant capacity (TAC) is unknown. Thus, our study asse
Braz J Med Biol Res. Publicado em: 19/10/2017
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21. Hepatoprotective Role of α-Lipoic acid and Thymoquinone in Acetaminophen- Induced Liver Injury: Down-Regulation of COX-2 and flt-1 Expression
ABSTRACT Acetaminophen (APAP) is a widely-used analgesic, while toxic doses of which induce liver injury. Inducible cyclooxygenase-2 (COX-2) is derived prostaglandins which play an anti-inflammatory role in acetaminophen-induced hepatotoxicity. Selective activation of vascular endothelial growth factor (VEGFR1, flt -1) on endothelial cells increased mRNA lev
Braz. arch. biol. technol.. Publicado em: 17/08/2017
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22. N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain
We determined the effect of N-acetylcysteine (NAC) on the expression of the phosphorylated p38 (p-p38) protein and superoxide anion generation (SAG), two important players in the processing of neuropathic pain, in the lumbosacral spinal cord of rats with chronic constriction injury (CCI)-induced neuropathic pain. The sciatic functional index (SFI) was also m
Braz J Med Biol Res. Publicado em: 16/02/2017
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23. Cytotoxic activity of Androctonus australis hector venom and its toxic fractions on human lung cancer cell line
Abstract Background: Several studies have showed that animal venoms are a source of bioactive compounds that may inhibit the growth of cancer cells, which makes them useful agents for therapeutic applications. Recently, it was established that venom toxins from scorpions induced cytotoxic, antiproliferative and apoptogenic effects on cancer cells. Therefore
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 01/12/2016
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24. Alterações intestinais inflamatórias e de estresse oxidativo em modelo experimental de hipertensão portal: ação da N-acetilcisteína
RESUMO Introdução: A Hipertensão Portal (HP) é caracterizada por uma vasodilatação no sistema portal, e o intestino é um dos órgãos gravemente acometidos. A N-acetilcisteína (NAC) é uma molécula com importantes propriedades, amplamente utilizada na clínica. Objetivo: Avaliar a ação da NAC no intestino de animais submetidos ao modelo animal d
J. Coloproctol. (Rio J.). Publicado em: 2016-12