Myocardial Contractility
Mostrando 13-24 de 170 artigos, teses e dissertações.
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13. Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles
OBJECTIVES: We investigated the influence of sildenafil on cardiac contractility and diastolic relaxation and examined the distribution of phosphodiesterase-5 in the hearts of hypertensive rats that were treated with by NG-nitro-L-arginine methyl ester (L-NAME). METHODS: Male Wistar rats were treated with L-NAME and/or sildenafil for eight weeks. The Langend
Clinics. Publicado em: 2011
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14. EFFECT OF AQUEOUS FRACTION OF LEAVES DE COSTUS SPIRALIS (JACQ.) ROSCOE CONTRACTILE FUNCTION ON HEART MAMMALS. / EFEITO DA FRAÇÃO AQUOSA DAS FOLHAS DE COSTUS SPIRALIS (JACQ.) ROSCOE SOBRE A FUNÇÃO CONTRÁTIL DO CORAÇÃO DE MAMÍFEROS.
Teas and infusions from C. spiralis leaf have largely been used by folk medicine as diuretic, hypotensor, cytotoxic, immunomodulator, antilithiasic, antidiarrheic, antispasmodic, antiurolitic, antimicrobian, antifungic, antioxidant, antileishmania activity, antiinflamatory, and antiedematogenic activity. In spite of these biological effects attributed to the
Publicado em: 2011
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15. Efeitos de um programa de exercício físico prévio ao infarto do miocárdio sobre a morfologia e a função contrátil do ventrículo esquerdo de ratos / Effects of a physical exercise program previous to myocardial infarction on the left ventricle morphology and contractile function of rats
The aim of this study was to verify the effects of a treadmill running program previous to myocardial infarction (MI) on the myocardium morphology and contractile function of rats. One-month old male Wistar rats were randomly divided into three groups: sedentary infarcted (INF SED, n = 13), exercised infarcted (INF EX, n = 26) and simulated infarction (SHAM,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/08/2010
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16. Human umbilical cord blood cells in infarcted rats
Therapy with bone marrow-derived cells has been used in ischemic patients with reported success. The aim of this study was to determine the therapeutic efficacy of fresh and frozen human umbilical cord blood cells (hUCB) in Wistar rats submitted to permanent occlusion of the left coronary artery. Three hours after myocardial infarction, 2 x 10(7) hUCB cells
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-03
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17. Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats
Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of d
Publicado em: 2010
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18. Ventricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in rats
Myocardial infarction leads to compensatory ventricular remodeling. Disturbances in myocardial contractility depend on the active transport of Ca2+ and Na+, which are regulated by Na+-K+ ATPase. Inappropriate regulation of Na+-K+ ATPase activity leads to excessive loss of K+ and gain of Na+ by the cell. We determined the participation of Na+-K+ ATPase in ven
Brazilian Journal of Medical and Biological Research. Publicado em: 04/09/2009
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19. Participação da isoforma proteína quinase C βII na insuficiência cardíaca / Involvement of protein kinase C βII in heart failure
Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality worldwide. Protein kinase C isozymes emerge as important potential therapeutic targets in chronic cardiovascular disease. However, individual PKC isozymes play different roles in the pathogenesis of cardiac diseases. Here, we charact
Publicado em: 2009
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20. Mithocondrial dysfunction and gene expression are mechanism envolved in the prograssion of hypertrophy to heart failure in mice CIRSKOand PGC-1βKO / Disfunção mitocondrial e expressão gênica alterada como mecanismos envolvidos na progressão da hipertrofia para insuficiência cardíaca em camundongos CIRSKO e PGC-1βKO
Heart failure (HF) is the end stage of different types of cardiovascular diseases and it is characterized by changes in the metabolic and myocardial contractility. We use the models cre-lox with specific knockout for insulin receptor substrate (IRS) and co-activator of PPAR (PGC-1b) (basal and pressure overload). The objective was understood the role in the
Publicado em: 2009
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21. Lead reduces tension development and the myosin ATPase activity of the rat right ventricular myocardium
Lead (Pb2+) poisoning causes hypertension, but little is known regarding its acute effects on cardiac contractility. To evaluate these effects, force was measured in right ventricular strips that were contracting isometrically in 45 male Wistar rats (250-300 g) before and after the addition of increasing concentrations of lead acetate (3, 7, 10, 30, 70, 100,
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-09
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22. Experimental model of heart failure in rabbits / Desenvolvimento de modelo experimental de insuficiencia cardiaca em coelhos
Introduction: The development of heart failure experimental models is important to better understanding of physiopathology and validation of new therapeutic strategies. Few previous reports compared the models within the same animal species. Objective: Development and standardization of heart failure experimental model in rabbits with two interventions. Mate
Publicado em: 2008
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23. Remodeling of dystrophin-glycoprotein complex, intercalated disk proteins, and contractile proteins in the hearts of mice subjected to sepsis induced by cecal ligation and puncture. / Remodelamento do complexo de glicoproteínas associadas à distrofina, do disco intercalar e das proteínas contráteis no coração de camundongos submetidos à sépsis induzida por ligação e perfuração do ceco
Sepsis and septic shock represent a complex syndrome of systemic inflammatory response, with multiple physiological and immunological abnormalities, commonly caused by bacterial infection. The most important consequence of the response is the involvement of many organs and tissues. Cardiac dysfunction, caused by impairment in myocardial contractility, has be
Publicado em: 2008
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24. Correlação entre função ventricular direita e capacidade funcional em pacientes com cardiopatia chagásica crônica
Chronic Chagas heart disease constitutes the most severe manifestation of Chagas disease, with great heterogeneity in its clinical presentation. The degree of myocardial dysfunction is a prognostic factor, but with no direct relation with the functional class. The present study evaluated the correlation between functional capacity and right ventricular funct
Publicado em: 2008