Mutation Biology
Mostrando 25-36 de 119 artigos, teses e dissertações.
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25. Estudo dos fatores de virulencia de amostras de Escherichia coli patogenicas de origem aviaria (APEC) / Study of the virulence factors from avian pathogenic Escherichia coli strains (APEC)
Two pathogenic Escherichia coZi strains isolated from avian (APEC) showing c1inical signs of septicemia (817 and 821), and one isolated from avian showing c1inical signs of 8wollen Head 8yndrome (8H8 1 O), were selected from a total of 49 strains belonging to the Laboratory of Bacterial Molecular Biology, after a biological characterization regarding the pre
Publicado em: 2006
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26. Oxyphilia in thyroid nodules: classification and relationship with immunohistochemical markers and mutations in BRAF and RAS genes and PAX8- PPARg rearrangement / Oxifilia nas lesões nodulares da tireóide: classificação e relação com marcadores imuno-histoquímicos e mutações nos genes BRAF e RAS e rearranjo PAX8-PPARgama
Uma série de 205 casos de lesões nodulares da tireóide foi revista morfologicamente de acordo com a nova classificação da Organização Mundial da Saúde (OMS, 2004) e analisada quanto à imuno-expressão das citoqueratinas 14 (CK 14) e 19 (CK19) e de citocromo-oxidase. Especial ênfase foi dada à avaliação da oxifilia nos nódulos, valorizando não
Publicado em: 2006
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27. Rastreamento de mutações nos genes PITX2, FOXC1 e GJA1 em pacientes com sindrome de Axenfeld-Rieger associada a glaucoma
Axenfeld-Rieger Syndrome (ARS) is arare disorder, usually transmitted in an autosomal dominant pattem characterized by anterior segment dysgenesis and often associated with developmental glaucoma. In addition to the ocular changes observed in ARS, syndromic features can also occur, such as facial bone defects, teeth anomalies and peri-umbilical skin involuti
Publicado em: 2005
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28. Do corpo-mÃquina ao corpo-informaÃÃo: o pÃs-humano como horizonte biotecnolÃgico
This research analyses the ways of problematization of the relations between body and new technologies put into practice by the media and academic field discoursive production. It is about thinking how the relation body and technology has become an issue, which discoursive practices, related with a variety of coexistent and lateral practices, has made this i
Publicado em: 2004
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29. Preliminar study of the expression of molecular markers in patients with stomach cancer, in Ceara State / Estudo preliminar da expressão de marcadores moleculares no câncer de estômago ocorridos no Estado do Ceará
In search for a better understanding of the biology of tumors, molecular markers related to proliferation, resistance and apoptosis have been intensively studied in the different types of cancer. These markers can help on the elucidation of more specific therapeutic targets for the treatment of various tumors. It was observed that stomach cancer is the secon
Publicado em: 2003
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30. Pesquisa de mutações nos genes p53 e K-ras em pacientes com carcinoma bronquico atendidos no serviço de oncopneumologia FCM/UNICAMP
Considered a rare illness in the beginning of 20th century, the lung cancer today is the more common visceral neoplasia and the main cause of death by cancer. The study of the molecular events involved in lung cancer is important for the knowledge of the process of carcinogenesis and for the determination of the mutational spectrum of the genes related to lu
Publicado em: 2002
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31. The yellow fever 17D vaccine virus as a vector for the expression of foreign proteins: development of new live flavivirus vaccines
The Flaviviridae is a family of about 70 mostly arthropod-borne viruses many of which are major public health problems with members being present in most continents. Among the most important are yellow fever (YF), dengue with its four serotypes and Japanese encephalitis virus. A live attenuated virus is used as a cost effective, safe and efficacious vaccine
Memórias do Instituto Oswaldo Cruz. Publicado em: 2000
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32. Molecular approaches to dysmorphology.
The biochemical and physiological defects underlying human dysmorphic syndromes can now be approached using techniques of molecular biology. The genetic component of the causation of the dysmorphology can be studied in isolation from the environmental component by using large, rare families which exhibit the same phenotype as more complex multifactorial diso
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33. Expanded versions of the 16S and 23S ribosomal RNA mutation databases (16SMDBexp and 23SMDBexp)
Expanded versions of the Ribosomal RNA Mutation Databases provide lists of mutated positions in 16S and 16S-like ribosomal RNA (16SMDBexp) and 23S and 23S-like ribosomal RNA (23SMDBexp) and the identity of each alteration. Alterations from organisms other than Escherichia coli are reported at positions according to the E.coli numbering system. Information pr
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34. The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage
Few data exist on somatic mutation in the epithelial cell lineages that play a central role in human biology and disease. To delineate the “landscape” of somatic mutation in a human epithelial cell lineage, we determined the frequency and molecular nature of somatic mutations occurring in vivo in the X-linked HPRT gene of kidney tubular epithelial cells.
The National Academy of Sciences.
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35. A test of evolutionary theories of aging
Senescence is a nearly universal feature of multicellular organisms, and understanding why it occurs is a long-standing problem in biology. The two leading theories posit that aging is due to (i) pleiotropic genes with beneficial early-life effects but deleterious late-life effects (“antagonistic pleiotropy”) or (ii) mutations with purely deleterious lat
National Academy of Sciences.
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36. Ontophyletics of the nervous system: eyeless mutants illustrate how ontogenetic buffer mechanisms channel evolution.
Genetics and molecular biology have shown the mechanisms that allow the genome to provide both the continuity and the variation from generation to generation within a phylogeny. Embryology and developmental biology show the mechanisms that turn the genome into an organism. Mutations, the basis for evolutionary change, cannot in themselves ensure concordance