Mutagenicity Testing
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. In vitro antifungal activity of Myracrodruon urundeuva Allemão against human vaginal Candida species
ABSTRACT Myracrodruon urundeuva is a plant native to Brazil, which is used by the indigenous population for the treatment of candidiasis. The aims of this study were to evaluate the antifungal activity of extract against human vaginal Candida species and evaluate the possible toxicological activities of M. urundeuva. Initially, ethanol extracts, ethyl acetat
An. Acad. Bras. Ciênc.. Publicado em: 24/07/2017
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2. Eco/genotoxicidade do corante comercial CI Disperse Red 1 e seus subprodutos clorados / Eco/genotoxicity of commercial dye CI Disperse Red 1 and chlorinated by-products
Cerca de 70% dos corantes utilizados em indústrias têxteis são corantes do tipo azo, que se caracterizam pelo grupo -N=N- ligado a sistemas aromáticos, sendo que a função azo inclui os principais tipos de corantes. A eliminação da cor no efluente é um grande desafio para o setor têxtil, já que, aproximadamente, 15% da produção mundial de corante
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012
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3. Genotoxicidade e indução de apoptose por Fluconazol em células de mamíferos in vitro
O Fluconazol é um antifúngico amplamente prescrito para combater candidíase e dermatomicoses, além de ser usado como medida profilática em transplantados, imunodeprimidos e pessoas com câncer. Apesar desse antimicótico já ser comercializado, é necessário farmacovigilância, que consiste em verificar efeitos prejudiciais dos medicamentos, visando pr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/01/2011
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4. Determination of the antimutagenicity of an aqueous extract of Rhizophora mangle L. (Rhizophoraceae), using in vivo and in vitro test systems
An aqueous extract of Rhizophora mangle L. bark is used as raw material in pottery making in the State of Espirito Santo, Brazil. This extract presents large quantities of tannins, compounds possessing antioxidant properties. Tannin antioxidant activity, as a plant chemical defense mechanism in the process of stabilizing free radicals, has been an incentive
Genetics and Molecular Biology. Publicado em: 18/12/2009
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5. Avaliação in vivo e in vitro da citotoxicidade, genotoxicidade e dos efeitos protetores de extratos de plantas do cerrado brasileiro
The use of plants for healing purposes is becoming increasingly popular, as soon as they are believed to be beneficial and free of side effects. However, most of information available on several medicinal herbs does not have any scientific supporting data and their use as medicaments is based simply on traditional folk. Among the plants used by the humanity
Publicado em: 2008
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6. Modulação do efeito mutagênico por fitoestrógenos : in vitro e in vivo
Alimentos e suplementos alimentares contendo fitoestrógenos estão sendo cada vez mais utilizados, pois estudos epidemiológicos apontam que a ingestão de alimentos ricos nesses fitoquímicos confere proteção contra várias formas de câncer. As isoflavonas, que são os fitoestrógenos mais conhecidos, são encontradas abundantemente no grão de soja (Gl
Publicado em: 2008
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7. Efeitos genotóxicos e mutagênicos da fração solúvel do óleo diesel em uma espécie de peixe Neotropical
ABSTRACT The present work shows results of the mutagenicity and genotoxicity evaluation of the comercial diesel oil fraction on freshwater fishes Prochilodus lineatus (Characiformes: Prochilodontidae), ordinarily known as curimba. The water containing the diesel oil soluble fraction was obtained through simulation of the spill in tropical environment. In the
Publicado em: 2006
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8. Evaluation of the mutagenic potential and in vitro metabolization of three anti-inflammatory parsalmide analogues / Avaliação do potencial mutagenico e metabolização in vitro de tres analogos do antiinflamatorio parsalmide
In this study, the mutagenicity of the anti-inflammatory parsaJmide [5-amino-N-butyl-2-(2-propynyloxy)-benzamide] analogues PA7 [5-anuno-N-butyl-2-cyclohexyloxy-benzamide], PA10 [5-amino-N-butyl-2-phenoxy-benzamide] and PA31 [5-arnino-N-butyl-2-(p-tolyloxy)-benzamide] was determined by an Ames Salmonella assay. The experiments were performed by preincubating
Publicado em: 2006
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9. Guidelines for the Testing of Chemicals for Mutagenicity
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10. Report of the UKEMS Sub-Committee on Guidelines for Mutagenicity Testing
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11. Mutagenicity testing with transgenic mice. Part I: Comparison with the mouse bone marrow micronucleus test
As part of a larger literature study on transgenic animals in mutagenicity testing, test results from the transgenic mutagenicity assays (lacI model; commercially available as the Big Blue® mouse, and the lacZ model; commercially available as the Muta™Mouse), were compared with the results on the same substances in the more traditional mouse bone marrow m
BioMed Central.
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12. Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker.
We have developed a quantitative forward mutation assay using Salmonella typhimurium, in which resistance to the purine analog 8-azaguanine is used as a genetic marker. We present the assay protocol, the concentration-dependent toxicity and mutagenicity of five known mutagens (N-methyl-N'-nitro-N-nitrosoguanidine, ICR-191, 9-aminoacridine, dimethylnitrosamin