Mutagenic
Mostrando 1-12 de 1136 artigos, teses e dissertações.
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1. Mutagenic damage among bronchiectasis patients attending in the pulmonology sector of a hospital in southern Brazil
SUMMARY OBJECTIVE: Bronchiectasis is a chronic respiratory disease characterized by inflammation, irreversible dilation of the bronchi, and recurrent pulmonary infections, with a high morbidity and mortality rate, but is less studied from the point of view of its prevalence and associated factors not directly related to respiratory prognosis. As it is a dis
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Functional properties and Bioactivities of Cleistocalyx nervosum var. paniala berry plant: a review
Abstract In treating various diseases, natural therapies are widely preferred in the modern era to synthetic drugs as they offer little or no side effects, in contrast to synthetic drugs. However, there is limited scientific knowledge about plants that have a broad range of medicinal properties. Cleistocalyx nervosum var. paniala, native to Thailand and gene
Food Sci. Technol. Publicado em: 2020-12
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3. Protective effects of bark ethanolic extract from Spondias dulcis Forst F. against DNA damage induced by benzo[a]pyrene and cyclophosphamide
Abstract This study evaluated the genotoxicity, mutagenicity, antigenotoxicity, and antimutagenicity effects on biochemical parameters of oxidative stress of the Spondias dulcis bark ethanolic extract on mice. The extract was evaluated in the doses of 500, 1000, and 1500 mg/kg bw via gavage. To evaluate the protective effects of the extract, benzo[a]pyrene (
Genet. Mol. Biol.. Publicado em: 14/11/2019
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4. DNA Damage by Endogenous and Exogenous Aldehydes
The present overview describes the formation of deoxyribonucleic acid (DNA) adducts from endogenous and exogenous aldehydes, such as acetaldehyde, acrolein, crotonaldehyde, malonaldehyde, 4-hydroxy-2-nonenal and 2,4-decadienal. Malonaldehyde reacts with 2’-deoxyguanosine, 2’-deoxyadenosine, and 2’-deoxycytidine, yielding cyclic pyrimidopurinone and acy
J. Braz. Chem. Soc.. Publicado em: 21/10/2019
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5. Avaliação de diferentes fatores na remoção de remazol brilliant blue de soluções aquosas por adsorção em fibras de cana de açúcar e coco verde
RESUMO As indústrias têxteis, durante o processo de tingimento, liberam uma grande quantidade de corantes na água. Além do seu efeito visual e seus impactos adversos em relação à fotossíntese e demanda química de oxigênio, muitos corantes sintéticos são tóxicos, recalcitrantes, mutagênicos e carcinogênicos. Dessa forma, novas alternativas de t
Matéria (Rio J.). Publicado em: 16/09/2019
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6. [PROVISIONAL] Role of error-prone DNA polymerases in spontaneous mutagenesis in Caulobacter crescentus
Abstract Spontaneous mutations are important players in evolution. Nevertheless, there is a paucity of information about the mutagenic processes operating in most bacterial species. In this work, we implemented two forward mutational markers for studies in Caulobacter crescentus. We confirmed previous results in which A:T→ G:C transitions are the most prev
Genet. Mol. Biol.. Publicado em: 02/09/2019
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7. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity
Currently, the pharmaceutical industry devotes great attention to drug degradation products because these compounds can offer risks to patients. A previous degradation study of betahistine (N-α-methyl-2-pyridylethylamine) conducted under different stress conditions detected three main impurities named A, B and C. Degradation products were analyzed by high-r
J. Braz. Chem. Soc.. Publicado em: 04/07/2019
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8. Evaluation of antimutagenic and cytotoxic activity of skin secretion extract of Rhinella marina and Rhaebo guttatus (Anura, Bufonidae)
RESUMO A secreção cutânea de anuros da família Bufonidae tem grande potencial na busca de novos compostos ativos para utilização como fármacos candidatos no tratamento de algumas doenças, entre elas o câncer. Neste contexto, este estudo teve como objetivo avaliar a atividade citotóxica e antimutagênica dos extratos da secreção da glândula paró
Acta Amaz.. Publicado em: 06/05/2019
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9. Ortho-nitrobenzyl derivatives as potential anti-schistosomal agents
ABSTRACT In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both the schistosomulum (somule) and adult forms of Schistosoma mansoni. Compounds 8 and 12 showed significant activity against somules at low micromolar concentrations, but none was active against adults. The SAR demonstrat
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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10. Augmented cytotoxic, mutagenic and genotoxic response triggered by carvedilol and celecoxib combinations
Abstract It is understood that drugs regardless of their order of administration can exhibit drug interactions. Established on the fact that treatment of hypertension may last for decades and prolong usage of multiple drug regimen may induce substantial pathophysiological changes. Hence, This study was designed to evaluate the possible synergistic toxic effe
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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11. Comet and cytogenetic tests as tools for evaluating genomic instability in seeds of Oryza sativa L. and Phaseolus vulgaris L. from gene banks
Abstract This study aimed to assess the feasibility of comet and cytogenetic tests as tools for evaluating genomic instability in seeds of Oryza sativa L. (rice) and Phaseolus vulgaris (beans) L. from gene banks. Rice and beans were exposed to methyl methanesulfonate (MMS) as a reference DNA damaging agent. Seeds of two accessions of rice and beans were obta
Genet. Mol. Biol.. Publicado em: 2018-03
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12. Short-term carcinogenesis evaluation of Casearia sylvestris
Abstract Casearia sylvestris Sw., Salicaceae, is an important medicinal plant widely used in Brazil for the treatment of various cardiovascular disorders. This species was included as of interest by Brazilian Unified Health System. Although preclinical studies described cardiovascular protective effects and apparent absence of toxicity, no studies have evalu
Rev. bras. farmacogn.. Publicado em: 2017-10