Mutability
Mostrando 13-24 de 143 artigos, teses e dissertações.
-
13. Regulation of the rulAB Mutagenic DNA Repair Operon of Pseudomonas syringae by UV-B (290 to 320 Nanometers) Radiation and Analysis of rulAB-Mediated Mutability In Vitro and In Planta
The effects of the rulAB operon of Pseudomonas syringae on mutagenic DNA repair and the transcriptional regulation of rulAB following irradiation with UV-B wavelengths were determined. For a rulB::Km insertional mutant constructed in P. syringae pv. syringae B86-17, sensitivity to UV-B irradiation increased and UV mutability decreased by 12- to 14-fold. rulA
American Society for Microbiology.
-
14. Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
Affinity maturation of antibodies requires localized hypermutation and antigen selection. Hypermutation is particularly active in certain regions (notably the CDRs of light and heavy chains) due to the local accumulation of hot spots. We have now analyzed the role of individual nucleotides in the origin of hot spots and show that mutability is largely d
The National Academy of Sciences of the USA.
-
15. A Search for a General Phenomenon of Adaptive Mutability
The most prominent systems for the study of adaptive mutability depend on the specialized activities of genetic elements like bacteriophage Mu and the F plasmid. Searching for general adaptive mutability, we have investigated the behavior of Salmonella typhimurium strains with chromosomal lacZ mutations. We have studied 30 revertible nonsense, missense, fram
-
16. Genetic Plasticity of V Genes Under Somatic Hypermutation: Statistical Analyses Using a New Resampling-Based Methodology
Evidence for somatic hypermutation of immunoglobulin genes has been observed in all of the species in which immunoglobulins have been found. Previous studies have suggested that codon usage in immunoglobulin variable (V) region genes is such that the sequence-specificity of somatic hypermutation results in greater mutability in complementarity-determining re
Cold Spring Harbor Laboratory Press.
-
17. Genetic control of enhanced mutability of mitochondrial DNA and gamma-ray sensitivity in Saccharomyces cerevisiae.
Five nuclear mutants enhancing the spontaneous mutation rate of mtDNA have been isolated in Saccharomyces cerevisiae. These mutators fall into five complementation groups and are located at five genetic loci different from rad50 to rad57 loci. Three mutants (gam1, gam2, and gam4), insensitive or weakly sensitive to gamma-rays, exhibit increased frequency of
-
18. Relations between Factors Controlling Crossing over and Mutability in Males of DROSOPHILA ANANASSAE
Several stocks, selected because they carried previously identified factors governing either crossing over in males or mutability, were examined to determine whether the effects of these factors are restricted to one or the other process. Neither of two dominant enhancers of male crossing over had detectable effects on Minute mutation frequencies among proge
-
19. Comparison of spontaneous, UV-induced, and nitrosoguanidine-induced mutability to drug resistance in myxobacteria.
The UV survival curves of different strains of myxobacteria exhibited shoulders; in the case of Polyangium luteum, an unusual double shoulder appeared. Repair inhibitors like acriflavine, caffeine, and coumarin reduced the survival of UV-irradiated cells if the drugs were incorporated in the post-irradiation plating medium. The shoulders were reduced, but th
-
20. An inducible pathway is required for mutagenesis in Salmonella typhimurium LT2.
UV mutability of Salmonella typhimurium LT2 was eliminated in the presence of a multicopy plasmid carrying the Escherichia coli lexA+ gene. This result suggests that inducible, SOS-like functions are required for UV mutagenesis in S. typhimurium. S. typhimurium strains carrying either point or deletion mutations in topA had previously been shown to lose thei
-
21. Morphogenetically Specific Mutability in DROSOPHILA ANANASSAE
A stock exhibiting hypermutability with respect to visible mutants (Om) affecting optic morphology was subjected to genetic analysis. The production of Om mutants, independently recovered with a frequency of two per 104, is restricted to females and depends primarily on homozygosity of their X chromosomes; in heterozygotes, Om mutability is stimulated by th
-
22. Asynapsis and Mutability in Drosophila Melanogaster
-
23. A BINARY MUTABILITY SYSTEM IN ESCHERICHIA COLI
-
24. Inheritance of Spontaneous Mutability in Yeast