Muscarinic
Mostrando 1-12 de 588 artigos, teses e dissertações.
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1. Behavioral effects of Bj-PRO-7a, a proline-rich oligopeptide from Bothrops jararaca venom
The heptapeptide Bj-PRO-7a, isolated and identified from Bothrops jararaca (Bj) venom, produces antihypertensive and other cardiovascular effects that are independent on angiotensin converting enzyme inhibition, possibly relying on cholinergic muscarinic receptors subtype 1 (M1R). However, whether Bj-PRO-7a acts upon the central nervous system and modifies b
Braz J Med Biol Res. Publicado em: 07/11/2019
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2. Curcuma Longa Abolishes Phenylephrine-Induced Contractions in Isolated Aortic Artery of Rats
Abstract Background: Curcuma longa has biological effects. Its cardiovascular activities are yet to be scientifically studied. Objectives: To investigate the vasorelaxant effects of the aqueous extract of Curcuma longa (AECL). Methods: Aortic annuli of normotensive rats, with or without endothelium, were set up in a data storage system with nutrient solut
Int. J. Cardiovasc. Sci.. Publicado em: 07/03/2019
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3. Dipyrone in association with atropine inhibits the effect on gastric emptying induced by hypoglycemia in rats
Atropine (AT) and dipyrone (Dp) induce a delay of gastric emptying (GE) of liquids in rats by inhibiting muscarinic receptors and activating β2-adrenergic receptors, respectively. The objective of the present study was to determine the effects of pretreatment with AT and Dp, given alone or in combination, on the effect of hypoglycemia in the liquid GE in ra
Braz J Med Biol Res. Publicado em: 31/08/2017
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4. Possible mechanisms involved in the vasorelaxant effect produced by clobenzorex in aortic segments of rats
Clobenzorex is a metabolic precursor of amphetamine indicated for the treatment of obesity. Amphetamines have been involved with cardiovascular side effects such as hypertension and pulmonary arterial hypertension. The aim of the present study was to investigate whether the direct application of 10–9–10–5 M clobenzorex on isolated phenylephrine-precont
Braz J Med Biol Res. Publicado em: 07/08/2017
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5. Antagonistas muscarínicos de longa duração vs. β 2 -agonistas de longa duração em exacerbações da DPOC: revisão sistemática e meta-análise
RESUMO Objetivo: Determinar se long-acting muscarinic antagonists (LAMAs, antagonistas muscarínicos de longa duração) são superiores a long-acting β2 agonists (LABAs, β2-agonistas de longa duração) na prevenção de exacerbações da DPOC. Métodos: Revisão sistemática e meta-análise de ensaios clínicos controlados aleatórios com pacientes com
J. bras. pneumol.. Publicado em: 2017-08
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6. Effects of nitric oxide inhibitors in mice with bladder outlet obstruction
ABSTRACT Purpose To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks of partial bladder outlet obstruction (BOO), in order to evaluate the role of constitutive and
Int. braz j urol.. Publicado em: 2017-04
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7. Pharmacological study of the mechanisms involved in the vasodilator effect produced by the acute application of triiodothyronine to rat aortic rings
A relationship between thyroid hormones and the cardiovascular system has been well established in the literature. The present in vitro study aimed to investigate the mechanisms involved in the vasodilator effect produced by the acute application of 10-8–10-4 M triiodothyronine (T3) to isolated rat aortic rings. Thoracic aortic rings from 80 adult male Wis
Braz J Med Biol Res. Publicado em: 25/07/2016
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8. Modulatory effects of taurine on jejunal contractility
Taurine (2-aminoethanesulfonic acid) is widely distributed in animal tissues and has diverse pharmacological effects. However, the role of taurine in modulating smooth muscle contractility is still controversial. We propose that taurine (5-80 mM) can exert bidirectional modulation on the contractility of isolated rat jejunal segments. Different low and high
Braz J Med Biol Res. Publicado em: 14/10/2014
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9. Effect of penehyclidine hydrochloride on β-arrestin-1 expression in lipopolysaccharide-induced human pulmonary microvascular endothelial cells
β-arrestins are expressed proteins that were first described, and are well-known, as negative regulators of G protein-coupled receptor signaling. Penehyclidine hydrochloride (PHC) is a new anti-cholinergic drug that can inhibit biomembrane lipid peroxidation, and decrease cytokines and oxyradicals. However, to date, no reports on the effects of PHC on β-ar
Braz J Med Biol Res. Publicado em: 02/12/2013
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10. Recent evidence and potential mechanisms underlying weight gain and insulin resistance due to atypical antipsychotics
Objective: Atypical antipsychotics (AAPs) promote obesity and insulin resistance. In this regard, the main objective of this study was to present potential mechanisms and evidence concerning side effects of atypical antipsychotics in humans and rodents. Method: A systematic review of the literature was performed using the MEDLINE database. We checked the
Rev. Bras. Psiquiatr.. Publicado em: 2013-09
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11. Effects of atropine and propranolol on lung inflammation in experimental envenomation: comparison of two buthidae venoms
Background Previous works had shown that scorpion venom induced neurotransmitter elevation and an inflammatory response associated with various anatomo-pathological modifications. The most dangerous scorpions species in Algeria responsible for these effects are Androctonus australis hector (Aah) and Androctonus amoreuxi (Aam). Results Comparison of the phys
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 09/04/2013
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12. Plasticidade sináptica no córtex pré-frontal induzida por estimulação do tálamo mediodorsal de ratos in vivo: efeitos da modulação colinérgica muscarínica e nicotínica / Prefrontal cortical synaptic plasticity induced by stimulation of the rat mediodorsal thalamus in vivo: effects of cholinergic muscarinic and nicotinic modulation
O núcleo talâmico mediodorsal (Tmd) e o córtex pré-frontal (CPF) comunicam-se mutuamente, formando um circuito envolvido em funções executivas e transtornos psiquiátricos. As funções executivas estão sujeitas aos níveis de alerta gerados pela atividade oscilatória talamocortical, que por sua vez é controlada pela transmissão colinérgica. Possi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/08/2012