Murine
Mostrando 13-24 de 12973 artigos, teses e dissertações.
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13. Hypothermia treatment ameliorated cyclin-dependent kinase 5-mediated inflammation in ischemic stroke and improved outcomes in ischemic stroke patients
OBJECTIVES: The inflammatory response is a key mechanism of neuronal damage and loss during acute ischemic stroke. Hypothermia has shown promise as a treatment for ischemic stroke. In this study, we investigated the molecular signaling pathways in ischemic stroke after hypothermia treatment. METHODS: Cyclin-dependent kinase 5 (CDK5) was overexpressed or si
Clinics. Publicado em: 21/10/2019
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14. Antitumor effect of depsidones from lichens on tumor cell lines and experimental murine melanoma
Abstract Lichens have exhibited numerous biological activities, including growth inhibition of tumor cells. This study evaluated the antiproliferative activity of hypostictic and salazinic acids against tumor cell lines (B16-F10, PC-03, MCF7, HT-29, HEP-G2, K562 and 786-0) by the SRB assay in vitro and antitumor activity in experimental murine melanoma in vi
Rev. bras. farmacogn.. Publicado em: 17/10/2019
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15. Antileishmanial activity and chemical composition from Brazilian geopropolis produced by stingless bee Melipona fasciculata
ABSTRACT Geopropolis is produced by some stingless bee species such as Melipona fasciculata and consists of a mixture of plant resins, salivary secretions of the bee, wax, and soil. This study evaluated the antileishmanial activity in vitro, cytotoxicity and chemical composition of geopropolis produced by M. fasciculata in the savannah region of Maranhão, B
Rev. bras. farmacogn.. Publicado em: 26/08/2019
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16. MORPHOLOGICAL CHARACTERIZATION OF COLORECTAL PITS USING AUTOFLUORESCENCE MICROSCOPY IMAGES
RESUMO CONTEXTO: O câncer colorretal é uma das patologias mais prevalentes. Seu prognóstico é ligado à detenção e ao tratamento precoces. Atualmente o diagnóstico é realizado por análise histológica de biópsias de pólipo, seguida de classificação morfológica. A classificação de padrões de Kudo é frequentemente utilizada para a diferenci
Arq. Gastroenterol.. Publicado em: 26/08/2019
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17. Cannabinoid receptor-1 antagonism: a new perspective on treating a murine schistosomal liver fibrosis model
BACKGROUND Formation of schistosomal granulomata surrounding the ova can result in schistosomiasis-associated liver fibrosis (SSLF). The current standard of treatment is praziquantel (PZQ), which cannot effectively reverse SSLF. The role of the cannabinoid (CB) receptor family in liver fibrosis has recently been highlighted. OBJECTIVES This study aimed t
Mem. Inst. Oswaldo Cruz. Publicado em: 05/08/2019
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18. Antineoplastic Effect of Procyanidin-rich Extract of Lafoensia Pacari in Lung Carcinoma Cells
Abstract Lafoensia pacari A. St. Hill has been used in traditional medicine as an anti-ulcerogenic and anti-inflammatory. Although there is an ethnopharmacological indication for cancer treatment, only a few studies have demonstrated its possible anticancer activity. Thus, the aims of this study were: (1) to evaluate the antineoplastic effect of L. pacari et
Braz. arch. biol. technol.. Publicado em: 01/08/2019
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19. Characterisation of ocular involvement in an experimental model of neuroschistosomiasis mansoni
The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short communication reports ocular histolopatho
Mem. Inst. Oswaldo Cruz. Publicado em: 15/07/2019
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20. A Microwave-Enhanced Synthesis and Biological Evaluation of N-Aryl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d ]pyrimidin-4-amines
A series of N-aryl-5,6,7,8-tetra-hydrobenzo[4,5]thieno[2,3-d ]pyrimidin-4-amines were synthesized in moderate to good yield by using a microwave-enhanced conditions. The selected compounds were evaluated for their cytotoxic effects (IC50 values) on human pulmonary carcinoma (A549), murine BALB/c spontaneous colon adenocarcinoma (CT26) and human hepatocellula
J. Braz. Chem. Soc.. Publicado em: 04/07/2019
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21. First description of a clinical case of murine typhus in Campeche, Mexico
Abstract Murine typhus is a flea-borne disease caused by Rickettsia typhi, which was first detected in Mexico in 1927. It was not until 1996 that the first systematized study involving this pathogen was conducted in two coastal states of Mexico. We now report the first confirmed case of murine typhus in the state of Campeche, which occurred in a male patient
Rev. Soc. Bras. Med. Trop.. Publicado em: 06/06/2019
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22. Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142
The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins in peripheral CD4+ T cells were quantified with qRT-PCR and western blot, respectively. Peripheral CD4+ T
Braz J Med Biol Res. Publicado em: 29/04/2019
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23. In vitro evaluation of Eugenia dysenterica in primary culture of human gingival fibroblast cells
Abstract: Eugenia dysenterica is a Brazilian tree investigated for its properties and bioactive compounds, which are believed to have both pharmacological and phytochemical therapeutic effects. The leaves of this tree contain tannins, flavonoids, terpenes, and saponins, with reportedly beneficial effects to the human body. Despite these therapeutic applicati
Braz. oral res.. Publicado em: 25/04/2019
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24. Protective effects of Ginger Essential Oil (GEO) against chemically-induced cutaneous inflammation
Abstract The inhibitory effects of ginger essential oil (GEO) on chemically-induced cutaneous inflammation were investigated. Three kind of experimental murine models, such as xylene-induced ear edema model, carrageenan-induced paw edema model and 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) model were exploited to evaluate the
Food Sci. Technol. Publicado em: 11/04/2019