Mouse Toxicity
Mostrando 13-24 de 357 artigos, teses e dissertações.
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13. Screening the toxicity and toxin content of blooms of the cyanobacterium Trichodesmium erythraeum (Ehrenberg) in northeast Brasil
Blooms of the cyanobacterium Trichodesmium occur in massive colored patches over large areas of tropical and subtropical oceans. Recently, the interest in such events has increased given their role in major nitrogen and carbon dioxide oceanic fluxes. Trichodesmium occurs all along the Brazilian coast and patches frequently migrate towards the coast. In this
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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14. Neisseria meningitidis antigens immune response study: toxoid as mice model adjuvant encapsulated in liposomes. / Estudo da imunogenicidade de antígenos de Neisseria meningitidis: utilização de toxóide como adjuvante, vetorizado em lipossomas, no modelo camundongo.
N.meningitidis is diplococcus gram-negative strict human patogen that similarly to other bacteria are surrounded by external membrane with lipids, proteins (OMP) and LPS. It has been one of the main causes of the meningitidis and other invading infections in the world. This work searched to use STX2 toxoid of E.coli as adjuvant for a possible and future vacc
Publicado em: 2008
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15. CARACTERIZAÇÃO FITOQUÍMICA E ATIVIDADES BIOLÓGICAS DE Centella asiatica (L.) Urban / Phytochemical caracterization and biological activities of Centella asiatica (L.) Urban
Centella asiatica (L.) Urban is a member of Umbelliferae family that presents pantropical distribution, being frequent around forests and as invaders of grown plants. C. asiatica contains triterpenic glycosides such as asiaticoside and madecassoside, and its acids (asiatic and madecassic). These molecules have been responsibles for several activities of its
Publicado em: 2008
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16. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Brazilian Journal of Medical and Biological Research. Publicado em: 21/08/2007
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17. Monitoração toxinológica do pescado comercializado nos municípios de São Sebastião e Caraguatatuba, SP / Toxinological monitoring of fisheries comercialized in São Sebastião and Caraguatatuba cities, São Paulo state
The Paralytic Shellfish Poisoning (PSP) toxins are well-known natural bioactive compounds due to their accidental consumption in contaminated seafood. These molecules, of which the most potent representative is saxitoxin (STX), are a class of neurotoxic alkaloids, having different isoforms and varied toxicities, that are produced by some cyanobacteria and so
Publicado em: 2007
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18. Toxicidade em camundongos devido à exposição prolongada a uma floração de cianobactérias contendo microcistinas: avaliações comportamental, hematológica, bioquímica e anatomopatológica / Toxicity in mice due to prolonged exposure to a cyanobacterial bloom containing microcystins: behavioral, hematological, biochemical and anatomopathological evaluations
Cyanobacteria (blue-green algae) are prokaryotic and photosynthetic organisms found in practically every type of liquid habitat and that can form great superficial masses of intense green color called blooms. The development of algal blooms on water surface occurs with a higher incidence and is recognised as being a potential health hazard due to the toxic n
Publicado em: 2007
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19. Estereologia e ultra-estrutura da mucosa da parte proximal do duodeno de camundongos submetidos ao alcoolismo experimental / Stereology and ultrastructure of the mucosa of mouse proximal duodenum submitted to experimental alcoholism
A1coholism consists in one of the greatest problems of pharmacodependence, generating one of the main concerns in world public health. Several gastrointestinal complications decurres from alcoholic beverage consumption. The recent scientific studies enphasys is concentrated in substances that can interfere on preservation, maintenance and function of the int
Publicado em: 2006
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20. A low-cost method to test cytotoxic effects of Crotalus vegrandis (Serpentes: Viperidae) venom on kidney cell cultures
The pathogenesis of the renal lesion upon envenomation by snakebite has been related to myolysis, hemolysis, hypotension and/or direct venom nephrotoxicity caused by the venom. Both primary and continuous cell culture systems provide an in vitro alternative for quantitative evaluation of the toxicity of snake venoms. Crude Crotalus vegrandis venom was fracti
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2005-06
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21. Chemoprotective effect of cysteamine against the induction of micronuclei by methyl methanesulfonate and cyclophosphamide
Cysteamine or 2-mercaptoethylamine (MEA) is an aminothiol with a well-known radioprotective action. No specific information is available in the literature about the possible chemoprotective action of MEA against genotoxic chemical agents. This paper presents the results of studies on the ability of MEA to protect mouse bone marrow polychromatic erythrocytes
Genetics and Molecular Biology. Publicado em: 2005-03
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22. Proerectile effect of an alkaloidical rich fraction isolated from aspidosperma ulei markgr.: in vivo and in vitro study. / Efeito pró-erétil de uma fração rica em alcalóides isolada de aspidosperma ulei markgr.: estudo in vivo e in vitro
The genus Aspidosperma (Apocyanaceae) is known to be rich in yohimbine type of indol alkaloids. This study was aimed to evaluate the alkaloid rich fraction (SF3-5) obtained from Aspidiosperma ulei Markgr. root bark for its general toxicity, behavioral effects in mice and a possible proerectile activity. Acute toxicity tests were performed to determine the LD
Publicado em: 2005
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23. Photocytotoxicity of a 5-nitrofuran-ethenyl-quinoline antiseptic (Quinifuryl) to P388 mouse leukemia cells
Quinifuryl (MW 449.52), 2-(5'-nitro-2'-furanyl)ethenyl-4-{N-[4'-(N,N-diethylamino)-1'-methylbutyl]carbamoyl} quinoline, is a water soluble representative of a family of 5-nitrofuran-ethenyl-quinoline drugs which has been shown to be highly toxic to various lines of transformed cells in the dark. In the present study, the toxicity of Quinifuryl to P388 mouse
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-12
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24. Toxicity of a cyanobacterial extract containing microcystins to mouse lungs
Toxic cyanobacteria in drinking water supplies can cause serious public health problems. In the present study we analyzed the time course of changes in lung histology in young and adult male Swiss mice injected intraperitoneally (ip) with a cyanobacterial extract containing the hepatotoxic microcystins. Microcystins are cyclical heptapeptides quantified by E
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-08