Motoneurons
Mostrando 1-12 de 159 artigos, teses e dissertações.
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1. Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity
Recovery of motor function after central nervous system (CNS) injury is dependent on the regeneration capacity of the nervous system, which is a multifactorial process influenced, among other things, by the role of neuromodulators such as serotonin. The neurotransmitter serotonin can promote neuronal regeneration but there are also reports of it causing rest
Braz J Med Biol Res. Publicado em: 14/02/2019
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2. Proposta e avaliação de um modelo computacional de gerador central de padrões / Proposal and evaluation of a computational model of Central Pattern Generator
The concept of Central Pattern Generator-CPG can be described as neural network capable of producing coordinated rhythmic locomotor activity apart from any external rhythm or sensorial stimuli. As this group of neurons are autonomic and are located in the spinal medulla, is experimentally observed that brainless animal‟s exhibit robotized locomotor act
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/06/2011
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3. Proposta e avaliação de um modelo computacional de gerador central de padrões / Proposal and evaluation of a computational model of Central Pattern Generator
The concept of Central Pattern Generator-CPG can be described as neural network capable of producing coordinated rhythmic locomotor activity apart from any external rhythm or sensorial stimuli. As this group of neurons are autonomic and are located in the spinal medulla, is experimentally observed that brainless animal‟s exhibit robotized locomotor act
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/06/2011
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4. Amplificação sináptica e interações não lineares na arborização dendrítica de modelos de motoneurônios / Synapti Amplication and Nonlinearities interations in the dendritics tree of motoneurons models
A partir de modelos de motoneurônios (MN) de geometria e estrutura complexa e capacidade de reproduzir as características de um motoneurônio real, este trabalho tem como objetivos verificar as diferenças funcionais entre sinapses proximais e distais, investigar as interações não lineares de ativações sinápticas e estudar a influência dos canais pe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/04/2010
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5. A computer simulation study of motoneuron models with active dendrites in response to synaptic inputs. / Estudo por simulação computacional de modelos de motoneurônios com dendrito ativo em resposta a entradas sinápticas.
Mathematical models of motoneurons have been developed as an aid to the understanding of phenomena involving the neuromuscular system, but most of these models have been based on the hypothesis of a passive dendritic tree. This holds for anesthetized animals but not necessarily during normal motor behavior of the intact animal. Experiments with decerebrate a
Publicado em: 2010
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6. Axotomy increases NADPH-diaphorase activity in the dorsal root ganglia and lumbar spinal cord of the turtle Trachemys dorbigni
Seven days after transection of the sciatic nerve NADPH-diaphorase activity increased in the small and medium neurons of the dorsal root ganglia of the turtle. However, this increase was observed only in medium neurons for up to 90 days. At this time a bilateral increase of NADPH-diaphorase staining was observed in all areas and neuronal types of the dorsal
Publicado em: 2010
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7. Amplificação sináptica e interações não lineares na arborização dendrítica de modelos de motoneurônios / Synapti Amplication and Nonlinearities interations in the dendritics tree of motoneurons models
A partir de modelos de motoneurônios (MN) de geometria e estrutura complexa e capacidade de reproduzir as características de um motoneurônio real, este trabalho tem como objetivos verificar as diferenças funcionais entre sinapses proximais e distais, investigar as interações não lineares de ativações sinápticas e estudar a influência dos canais pe
Publicado em: 2010
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8. The immunomodulator glatiramer acetate influences spinal motoneuron plasticity during the course of multiple sclerosis in an animal model
The immunomodulador glatiramer acetate (GA) has been shown to significantly reduce the severity of symptoms during the course of multiple sclerosis and in its animal model - experimental autoimmune encephalomyelitis (EAE). Since GA may influence the response of non-neuronal cells in the spinal cord, it is possible that, to some extent, this drug affects the
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
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9. Investigação da ação neuroprotetora do fator neurotrofico ciliar (CNTF) conjugado com peptideo contendo dominio de translocação de proteina (PTD) / Investigation of neuroprotective action of ciliary neurotrophic factor (CNTF) fused to a protein transduction domain (PTD)
Ciliary neurotrophic factor (CNTF) is known as a neuroprotective agent on motoneurons after peripheral nerve section in neonatal rats and adult mice. However, side effects like weight loss and caquexia have limited its clinical use. A promising approach for the avoidance of such side effects is the fusion of a protein transduction domain (PTD) with CNTF. Pre
Publicado em: 2009
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10. Influence of Glatiramer acetate on the synaptic stability and glial reaction during the EAE and after motor root avulsion / Influencia do acetato de glatiramer (AG) sobre a estabilidade sinaptica e reação glial durante o curso da EAE e apos avulsão de raizes motoras
Multiple sclerosis (MS) is an inflammatory and demyelinating disease, which etiology is unknown. Although it is the result of a major autoimmune response. The Glatiramer acetate (GA) is a drug used to treat MS and is composed by four peptides homologous to the myelin basic protein (MBP), that is able to reduce the exacerbation and injuries to the CNS. Nevert
Publicado em: 2009
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11. Evaluation of the muscle strength and motor ability in children with spinal muscle atrophy type II and III treated with valproic acid / Avaliação da força muscular e da habilidade motora das crianças com amiotrofia espinhal progressiva do tipo II e III medicadas com ácido valpróico
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder that affects the spinal motoneurons, resulting in hypotonia and muscle weakness. The knowledge of the molecular mechanism of SMA has originated new researches including clinical trials with pharmacological agents that increase SMN2 protein level. Many drugs with this action are being tested wit
Publicado em: 2009
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12. Effects of systemic administration of ciliary neurotrophic factor on Bax and Bcl-2 proteins in the lumbar spinal cord of neonatal rats after sciatic nerve transection
Ciliary neurotrophic factor (CNTF) is a cytokine that plays a neuroprotective role in relation to axotomized motoneurons. We determined the effect of daily subcutaneous doses of CNTF (1.2 µg/g for 5 days; N = 13) or PBS (N = 13) on the levels of mRNA for Bcl-2 and Bax, as well as the expression and inter-association of Bcl-2 and Bax proteins, and the surviv
Brazilian Journal of Medical and Biological Research. Publicado em: 31/10/2008