Montelukast
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Montelukast Has no Impact on the Systemic Production of TGFβ-1 in Patients with Nasal Polyposis Associated with Aspirin Intolerance
Abstract Introduction Nasal polyposis is a disease characterized by a mechanical dysfunction of the nasal mucosa, closely related to the unique makeup of its extracellular matrix, which develops as the result of an anomalous tissue remodeling process. Transforming growth factor beta 1 (TGF-β1) is reduced not only in the nasal polypoid tissue, but also in
Int. Arch. Otorhinolaryngol.. Publicado em: 2021-01
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2. The impact of asthma and its treatment on growth: an evidence-based review
Resumo Objetivos: Avaliar o impacto da asma e seu tratamento (corticosteroides inalados e outros medicamentos de controle) no crescimento. Fontes de dados: Uma busca foi feita no PubMed (até 24 de agosto de 2018) e foram triadas as listas de referência dos artigos recuperados. Revisões sistemáticas e metanálises foram selecionadas. Se não houvesse ta
J. Pediatr. (Rio J.). Publicado em: 18/04/2019
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3. Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil
Abstract Purpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/
Acta Cir. Bras.. Publicado em: 2017-09
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4. The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats
ABSTRACT PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative sta
Acta Cir. Bras.. Publicado em: 2016-08
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5. Electroanalytical Characterization of Montelukast Sodium and Its Voltammetric Determination in Pharmaceutical Dosage Form and Biological Fluids
The electrochemical properties of montelukast sodium (MKST) at zinc oxide nanoparticles modified carbon paste electrode were investigated by cyclic voltammetry and square wave voltammetry. All studies were based on the irreversible and adsorption-controlled electrochemical reduction signal of montelukast sodium at about -0.7 vs. Ag/AgCl at pH 2.3 in methanol
J. Braz. Chem. Soc.. Publicado em: 2016-05
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6. Montelukast reduces seizures in pentylenetetrazol-kindled mice
Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast,
Braz J Med Biol Res. Publicado em: 23/02/2016
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7. Beneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats
Introductıon Ureteral obstruction is a common pathology and caused kidney fibrosis and dysfunction at late period. In this present, we investigated the antifibrotic and antiinflammatory effects of montelukast which is cysteinyl leukotriene receptor antagonist, on kidney damage after unilateral ureteral obstruction(UUO) in rats. Mateirıals and Methods 32 r
Int. braz j urol.. Publicado em: 2015-04
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8. Estudo da ativação eosinofílica e de matriz extracelular de tecido pulmonar periférico em cobaias com inflamação alérgica pulmonar: efeitos do tratamento com dexametasona e antagonista do receptor do cisteinil-leucotrieno D4
Aims: Compare the effects of montelukast or dexamethasone treatments on eosinophilic recruitment, eotaxin, RANTES, fibronectin, IGF-I and NF-B positive cells of distal lung parenchyma and also in airway walls of guinea pigs (GP) with chronic allergic inflammation. Methods: GP were inhaled with ovalbumin (OVA group-2x/week/4weeks). After 4th inhalation, GP we
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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9. Desenvolvimento farmacotécnico e analítico de comprimidos revestidos de montelucaste: equivalência farmacêutica e bioequivalência / Pharmaceutical and analytical development film coated tablets of montelukast: pharmaceutical equivalence and bioequivalence
O Montelucaste é um potente inibidor seletivo reversível do receptor cisteinil-leucotrieno-1, evitando que os mediadores provoquem a resposta asmática. Sua comercialização no Brasil, na forma de produto acabado, é protegida por patente até 2010. Uma vez que o fármaco Montelucaste é recente no mercado farmacêutico e não há descrição de metodolog
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/03/2011
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10. Influência do montelucaste sobre o estado de ativação dos eosinófilos e função dos fagócitos em crianças asmáticas
Asthma is one of the most common chronic diseases in childhood and its prevalence and severity are increasing in many parts of the world in recent years. The main characteristic of asthma is inflammation of the lower airways, responsible for bronchial hyperresponsiveness and variable airflow limitation, reversible with or without treatment. Several cells pla
Publicado em: 2010
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11. Inibição da contratilidade do músculo liso traqueal de ratos por um diterpeno caurano isolado de Croton argyrophylloides / Inhibition of tracheal smooth muscle contractility of rats by a diterpene isolated from Croton caurano argyrophylloides
Diversos diterpenos cauranos isolados de extratos de plantas têm mostrado ação antiespasmódica em diferentes músculos lisos. Nesse estudo, avaliamos os efeitos do rel-(1S, 4aS, 7S, 8aS)-7-(1-vinil)-tetradecahidro-1,4a-dimetilfenantreno-7,8a carbolactona-1-carboxílico (ATCC), um novo diterpeno caurano recentemente isolado de Croton argyrophylloides, em
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/12/2009
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12. Relaxamento do músculo liso traqueal de rato pelo eugenol. / Relaxation of rat tracheal smooth muscle by eugenol.
Eugenol, a phenol monoterpenoid, is the main component of clove oil. This study aims to evaluate the relaxation of tracheal smooth muscle of rat by eugenol and the mechanisms underlying these effects. We used preparations of trachea of male Wistar rats maintained in aerated modified Tyrode to record isometric muscle contractions. Increasing and cumulative co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2009