Monoclonal Antibody
Mostrando 25-36 de 6537 artigos, teses e dissertações.
-
25. ANVISA APPROVES THE FIRST BIOSIMILAR MONOCLONAL ANTIBODY BASED ON COMPARABILITY IN BRAZIL
Arq. Gastroenterol.. Publicado em: 2016-06
-
26. Biosensor Based on Cysteine Monolayer and Monoclonal Antibody for Specific Detection of Aflatoxin B1 in Rice
An electrochemical immunosensor for detection of aflatoxin B1 (AFB1) in food samples was developed. The sensor is composed by cysteine monolayer immobilized on gold electrode surface with subsequent bind to monoclonal antibody (MAb-Cys-modified electrode). The AFB1 detection was evaluated by cyclic voltammetry and impedance spectroscopy in the frequency rang
J. Braz. Chem. Soc.. Publicado em: 2016-06
-
27. Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations
Respiratory syncytial virus (RSV) infection is the leading cause of hospitalisation for respiratory diseases among children under 5 years old. The aim of this study was to analyse RSV seasonality in the five distinct regions of Brazil using time series analysis (wavelet and Fourier series) of the following indicators: monthly positivity of the immunofluoresc
Mem. Inst. Oswaldo Cruz. Publicado em: 29/03/2016
-
28. Insights into the posttranslational structural heterogeneity of thyroglobulin and its role in the development, diagnosis, and management of benign and malignant thyroid diseases
ABSTRACT Thyroglobulin (Tg) is the major glycoprotein produced by the thyroid gland, where it serves as a template for thyroid hormone synthesis and as an intraglandular store of iodine. Measurement of Tg levels in serum is of great practical importance in the follow-up of differentiated thyroid carcinoma (DTC), a setting in which elevated levels after total
Arch. Endocrinol. Metab.. Publicado em: 2016-02
-
29. Protein Expression and Codon 72 Polymorphism of TP53 Gene in Triple Negative Breast Cancer
A subgroup of tumor that has received attention is triple-negative breast cancer (TNBC), which presents phenotype of negative estrogen receptor, negative progesterone receptor and has no overexpression of HER2. TP53 acts as a tumor suppressor limiting the proliferation of damaged cells. A polymorphic site (rs1042522) of TP53 encodes either an arginine or a p
Braz. arch. biol. technol.. Publicado em: 2014-12
-
30. The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
Psoriasis is a chronic inflammatory, immune-mediated disease that affects 1% to 2% of the world's population. Immunobiological medications are prescribed for certain patients with severe forms of psoriasis, however, these drugs increase the risk of reactivation of viral diseases such as hepatitis B. We report the case of a patient with severe psoriasis with
An. Bras. Dermatol.. Publicado em: 2014-07
-
31. Expression, production, and renaturation of a functional single-chain variable antibody fragment (scFv) against human ICAM-1
Intercellular adhesion molecule-1 (ICAM-1) is an important factor in the progression of inflammatory responses in vivo. To develop a new anti-inflammatory drug to block the biological activity of ICAM-1, we produced a monoclonal antibody (Ka=4.19×10−8 M) against human ICAM-1. The anti-ICAM-1 single-chain variable antibody fragment (scFv) was expressed at
Braz J Med Biol Res. Publicado em: 04/06/2014
-
32. Pharmacological management of osteogenesis
Osteogenesis and bone remodeling are complex biological processes that are essential for the formation of new bone tissue and its correct functioning. When the balance between bone resorption and formation is disrupted, bone diseases and disorders such as Paget's disease, fibrous dysplasia, osteoporosis and fragility fractures may result. Recent advances in
Clinics. Publicado em: 2014-06
-
33. Cutaneous melanoma: new advances in treatment
Cutaneous melanoma is a challenge to treat. Over the last 30 years, no drug or combination of drugs demonstrated significant impact to improve patient survival. From 1995 to 2000, the use of cytokines such as interferon and interleukin become treatment options. In 2011, new drugs were approved by the U.S. Food and Drug Administration, including peginterferon
An. Bras. Dermatol.. Publicado em: 2014-04
-
34. Trypan blue exclusion assay by flow cytometry
Dye exclusion tests are used to determine the number of live and dead cells. These assays are based on the principle that intact plasma membranes in live cells exclude specific dyes, whereas dead cells do not. Although widely used, the trypan blue (TB) exclusion assay has limitations. The dye can be incorporated by live cells after a short exposure time, and
Braz J Med Biol Res. Publicado em: 18/03/2014
-
35. Segmental vitiligo after infliximab use for rheumatoid arthritis - A case report
The tumor necrosis factor alpha is a cytokine related to immune and inflammatory processes by acting on different parts of the body. It is secreted by several cell types including macrophages, lymphocytes, monocytes, neutrophils, dendritic cells, among others. Infliximab is a chimeric monoclonal antibody that specifically binds to soluble and transmembrane t
An. Bras. Dermatol.. Publicado em: 2014-01
-
36. Proteomic data show an increase in autoantibodies and alpha-fetoprotein and a decrease in apolipoprotein A-II with time in sera from senescence-accelerated mice
We evaluated changes in levels by comparing serum proteins in senescence-accelerated mouse-prone 8 (SAMP8) mice at 2, 6, 12, and 15 months of age (SAMP8-2 m, -6 m, -12 m, -15 m) to age-matched SAM-resistant 1 (SAMR1) mice. Mice were sacrificed, and blood was analyzed by 2-dimensional electrophoresis combined with mass spectrometry. Five protein spots were pr
Braz J Med Biol Res. Publicado em: 12/04/2013