Molecular Motor Proteins
Mostrando 1-12 de 73 artigos, teses e dissertações.
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1. Investigações estruturais dos domínios funcionais das miosinas classes VIII e XI presentes em plantas / Structural investigations of the functional domains of plant myosins (classes VIII and XI)
As miosinas formam uma superfamília de proteínas de alto peso molecular com atividade mecanoquímica capaz de hidrolisar a molécula de ATP e de interagir com os filamentos de actina. A estrutura das miosinas pode ser divida de modo geral em cabeça motora, pescoço e cauda. São conhecidas 35 classes de miosinas em eucariotos sendo a classe II de miosinas
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012
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2. Mecanismos intraflagelares de transporte e trânsito de proteínas: uma abordagem pós-genômica e computacional de caracterização da virulência flagelar em Leishmania spp. / Intraflagelares mechanisms of transport and transit proteins: a post-genomics and computational characterization of virulence flagellar Leishmania spp.
Leishmania are flagellated protozoa that cause a main neglected diseasease, collectively known as leishmaniases, posing a constant challenge for the control and prevention of the disease due to the wide-world distribution and prevalence of these parasites. As an insinuating pathogen, Leishmania has a specialized organelle for motility, the flagellum, which i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/01/2011
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3. O COMPLEXO METILMERCÚRIO-CISTEÍNA ALTERA O ACÚMULO DE MERCÚRIO EM DIFERENTES TECIDOS DE CAMUNDONGO / COMPLEX METHILMERCURY CYSTEINE ALTERS MERCURY ACCUMULATION IN DIFFERENT TISSUES OF MICE
Methylmercury (MeHg) is related to several deleterious effects on the vertebrate tissues, mainly on central nervous system, and part of these effects are through of interaction with sulfhydryl group found in cellular proteins. MeHg interacts with low and high molecular weight thiols in the blood and tissues and this fact, in some cases will allow a better ab
Publicado em: 2009
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4. Movimento bidirecional no transporte intracelular mediado por motores moleculares / Bidirectional movement in the intracellular transport mediated by molecular motors
In this work we present a theoretical model to describe aspects of the bidirectional movement performed by intracellular structures (vesicles, organelles, viruses etc, to which we refer here simply as "vesicles"), observed essentially at in vivo experiments. This nondifusive movement is characterized by rapid inversions in direction and is capable of creatin
Publicado em: 2007
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5. Aspectos do envelhecimento cerebral e função cognitiva em modelo experimental animal e estudo de mecanismos de neurodegeneração em cultura celular
The two phenomena, biological and behavioural, approached in the present work are brain aging and spatial memory. Several studies, comparative and experimental, have shown that aged subjects present significantly impaired performances in different types of cognitive tasks. It is also known that contradictions in literature exist in relation to consequences o
Publicado em: 2007
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6. Desmin: molecular interactions and putative functions of the muscle intermediate filament protein
Desmin is the intermediate filament (IF) protein occurring exclusively in muscle and endothelial cells. There are other IF proteins in muscle such as nestin, peripherin, and vimentin, besides the ubiquitous lamins, but they are not unique to muscle. Desmin was purified in 1977, the desmin gene was characterized in 1989, and knock-out animals were generated i
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-12
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7. Protein defects in neuromuscular diseases
Muscular dystrophies are a heterogeneous group of genetically determined progressive disorders of the muscle with a primary or predominant involvement of the pelvic or shoulder girdle musculature. The clinical course is highly variable, ranging from severe congenital forms with rapid progression to milder forms with later onset and a slower course. In recent
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
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8. Mechanical force generation by G proteins
GTP-hydrolyzing G proteins are molecular switches that play a critical role in cell signaling processes. Here we use molecular dynamics simulations to show that Ras, a monomeric G protein, can generate mechanical force upon hydrolysis. The generated force levels are comparable to those produced by ATP-hydrolyzing motor proteins, consistent with the structura
The National Academy of Sciences.
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9. Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein.
The kinesin heavy chain and the ncd (non-claret disjunctional) gene product of Drosophila are microtubule-associated motor proteins related by sequence similarity within an approximately 340-aa domain. Despite the sequence similarity, the kinesin heavy chain and ncd protein move in opposite directions on microtubules. To investigate the molecular basis for d
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10. Single-molecule investigation of the interference between kinesin, tau and MAP2c
Motor proteins and microtubule-associated proteins (MAPs) play important roles in cellular transport, regulation of shape and polarity of cells. While motor proteins generate motility, MAPs are thought to stabilize the microtubule tracks. However, the proteins also interfere with each other, such that MAPs are able to inhibit transport of vesicles and organe
Oxford University Press.
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11. Function of Protonatable Residues in the Flagellar Motor of Escherichia coli: a Critical Role for Asp 32 of MotB
Rotation of the bacterial flagellar motor is powered by a transmembrane gradient of protons or, in some species, sodium ions. The molecular mechanism of coupling between ion flow and motor rotation is not understood. The proteins most closely involved in motor rotation are MotA, MotB, and FliG. MotA and MotB are transmembrane proteins that function in transm
American Society for Microbiology.
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12. Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis.
The kinesin superfamily of molecular motors comprises proteins that participate in a wide variety of motile events within the cell. Members of this family share a highly homologous head domain responsible for force generation attached to a divergent tail domain thought to couple the motor domain to its target cargo. Many kinesin-related proteins (KRPs) parti