Molecular Alterations
Mostrando 13-24 de 804 artigos, teses e dissertações.
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13. The human adrenal cortex: growth control and disorders
This review summarizes key knowledge regarding the development, growth, and growth disorders of the adrenal cortex from a molecular perspective. The adrenal gland consists of two distinct regions: the cortex and the medulla. During embryological development and transition to the adult adrenal gland, the adrenal cortex acquires three different structural and
Clinics. Publicado em: 06/09/2018
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14. Two independent grain-length mutants mapped to a single region on the long arm of chromosome 2 in rice
ABSTRACT Grain shape in rice is a key determinant of grain appearance, yield and market value, and thus has been widely studied. Rice mutant lines with long-grain phenotypes were previously isolated from an M2 population derived from mutagenized mature pollen grains that were treated with gamma-ray irradiation for a cultivar Ma85. To understand the genetic b
Bragantia. Publicado em: 02/08/2018
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15. Reactive oxygen species generation mediated by NADPH oxidase and PI3K/Akt pathways contribute to invasion of Streptococcus agalactiae in human endothelial cells
BACKGROUND Streptococcus agalactiae can causes sepsis, pneumonia, and meningitis in neonates, the elderly, and immunocompromised patients. Although the virulence properties of S. agalactiae have been partially elucidated, the molecular mechanisms related to reactive oxygen species (ROS) generation in infected human endothelial cells need further investigati
Mem. Inst. Oswaldo Cruz. Publicado em: 05/04/2018
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16. Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama
ABSTRACT Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and m
Rev. Inst. Med. trop. S. Paulo. Publicado em: 15/02/2018
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17. Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise
Abstract Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other o
Motriz: rev. educ. fis.. Publicado em: 02/05/2017
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18. Radiation exposure and thyroid cancer: a review
ABSTRACT The association between radiation exposure and the occurrence of thyroid cancer has been well documented, and the two main risk factors for the development of a thyroid cancer are the radiation dose delivered to the thyroid gland and the age at exposure. The risk increases after exposure to a mean dose of more than 0.05-0.1 Gy (50-100mGy). The risk
Arch. Endocrinol. Metab.. Publicado em: 16/02/2017
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19. Replacement of native vegetation alters the soil microbial structure in the Pampa biome
ABSTRACT: Land use change is one of the the major factors related to soil degradation and alterations in soil microbial diversity and structure. In this study, we aimed to evaluate the microbial shifts caused by deforestation of a small area of a natural forest for the introduction of a pasture in the Brazilian Pampa. The microbial abundance and structure we
Sci. agric. (Piracicaba, Braz.). Publicado em: 2017-02
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20. N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis
BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-02
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21. Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease?
Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their malignant cells. Given that gastric cancer is the third
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
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22. Phylogenetic analysis of Dengue virus 1 isolated from South Minas Gerais, Brazil
Abstract Dengue is a major worldwide public health problem, especially in the tropical and subtropical regions of the world. Primary infection with a single Dengue virus serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients who experience secondary infection with a different serotype can progress to a more s
Braz. J. Microbiol.. Publicado em: 2016-03
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23. Association of human papillomavirus and Chlamydia trachomatis with intraepithelial alterations in cervix samples
The influence of different infectious agents and their association with human papillomavirus (HPV) in cervical carcinogenesis have not been completely elucidated. This study describes the association between cytological changes in cervical epithelium and the detection of the most relevant aetiological agents of sexually transmitted diseases. Samples collecte
Mem. Inst. Oswaldo Cruz. Publicado em: 02/02/2016
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24. STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL
ABSTRACT Objective: To evaluate the structural and molecular changes in the extracellular matrix (ECM) during the process of intervertebral disc degeneration, using animal model. Methods: Wistar rats underwent intervertebral disc degeneration through 20-gauge needle puncture, and 360° rotation applied for 30 sec, representing the degenerated group, whil
Acta ortop. bras.. Publicado em: 2016-02