Mitogen Activated Protein Kinase Kinases
Mostrando 1-12 de 628 artigos, teses e dissertações.
-
1. Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis
Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Viability, proliferat
Braz J Med Biol Res. Publicado em: 14/02/2019
-
2. The p38 MAPK and NF-κB Pathways are Involved in Cyclic Compressive Force-induced IL-6 Secretion in MLO-Y4 Cells
ABSTRACT We previously revealed the involvement of extracellular regulated protein kinases 1/2 (ERK1/2) in interleukin-6 (IL-6) secretion induced by cyclic compressive force (CCF) in MLO-Y4 cells. In this study, we investigated the contributions of the p38 mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways to IL-6 secretion by s
Braz. arch. biol. technol.. Publicado em: 29/11/2018
-
3. Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-κB and MAPK pathways
Tubular-interstitial nephritis (TIN) is characterized by tubular cell damage and inflammatory lesions of kidneys. Baicalein (BAI) is a flavonoid compound found in the roots of Scutellaria baicalensis Georgi. The present study was undertaken to explore the anti-inflammatory and anti-oxidative effects of BAI on TIN patients and a lipopolysaccharide (LPS)-induc
Braz J Med Biol Res. Publicado em: 06/08/2018
-
4. Interleukin-27 augments the inhibitory effects of sorafenib on bladder cancer cells
Both sorafenib and interleukin-27 (IL-27) are antineoplastic drugs. This study aimed to investigate the synergistic effect of these two drugs on bladder cancer cells. HTB-9 and T24 cells were stimulated with IL-27 (50 ng/mL), sorafenib (2 μM) or the synergistic action of these two drugs. The cells without treatment acted as control. Cell proliferation, apop
Braz J Med Biol Res. Publicado em: 20/07/2017
-
5. Characterization of the Relationship of CDKL5 with MeCP2 and Dnmt1 in PrimaryRat Cortical Neurons
ABSTRACT Cyclin-dependent kinase-like 5 (CDKL5) is a protein kinase that is homologous to mitogen-activated protein kinases (MAPKs) and cyclin-dependent kinases (CDKs). Mutations in the CDKL5 gene cause X-linked infantile spasms and phenotypes that overlap with that of Rett syndrome, which is a neurodevelopmental disorder caused primarily by mutations in the
Braz. arch. biol. technol.. Publicado em: 07/07/2016
-
6. Normal mesenteric lymph ameliorates lipopolysaccharide challenge-induced spleen injury
PURPOSE: This study was conducted to investigate the effect of normal mesenteric lymph (NML) from mice on the spleen injury induced by lipopolysaccharide (LPS) challenge.METHODS: Mice in the LPS and LPS+NML groups received an intraperitoneal injection of LPS (35 mg/kg) and kept for 6 h.. The mice in the LPS+NML group received NML treatment at 1 h after LPS i
Acta Cir. Bras.. Publicado em: 2015-09
-
7. MAPK immunoreactivity in streptozotocin-induced diabetic rat testis
PURPOSE: To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes. METHODS: Twenty males Sprague-Dawley rats were randomly divided into a control group (n=8) and a diabetes group (administration of
Acta Cir. Bras.. Publicado em: 2014-10
-
8. ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells
The present study focuses on the neuroprotective effect of glycyrrhizic acid (GA, a major compound separated from Glycyrrhiza Radix, which is a crude Chinese traditional drug) against glutamate-induced cytotoxicity in differentiated PC12 (DPC12) cells. The results showed that GA treatment improved cell viability and ameliorated abnormal glutamate-induced alt
Braz J Med Biol Res. Publicado em: 25/07/2014
-
9. Vias de sobrevivência e morte em queratinócitos submetidos ao estresse oxidativo e choque hiperosmótico / Survival and death signaling pathways in keratinocytes exposed to oxidative stress and hyperosmotic shock
The epidermis is constantly confronted with multiple environmental stressors. Changes in humidity or exposition to UV radiation affect the redox state and osmotic balance, modifying the physiological characteristics of the skin. In response to different stresses, epidermal keratinocytes can activate distinct signaling pathways and the balance between death a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2011
-
10. Efeitos da administração intraestriatal aguda de ácido quinolítico sobre o citoesqueleto de células neurais de ratos
In the present study we investigated the effect of in vivo intrastriatal injection of quinolinic acid (QA) on rat cytoskeleton proteins in astrocytes and neurons of young rats at early stages (30 min) after infusion. Intrastriatal QA injection is an excitotoxic model of Huntington´s Disease (HD). Results showed that QA (150¿mol/0.5¿L) significantly increa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
-
11. Roles of mitogen-activated protein kinases and angiotensin II in renal development
Experimental and clinical evidence suggests that angiotensin II (AII) participates in renal development. Renal AII content is several-fold higher in newborn rats and mice than in adult animals. AII receptors are also expressed in higher amounts in the kidneys of newborn rats. The kidneys of fetuses whose mother received a type 1 AII receptor (AT1) antagonist
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-01
-
12. The role of stress-activated protein kinase signaling in renal pathophysiology
Two major stress-activated protein kinases are the p38 mitogen-activated protein kinase (MAPK) and the c-Jun amino terminal kinase (JNK). p38 and JNK are widely expressed in different cell types in various tissues and can be activated by a diverse range of stimuli. Signaling through p38 and JNK is critical for embryonic development. In adult kidney, p38 and
Brazilian Journal of Medical and Biological Research. Publicado em: 07/11/2008