Mitochondrial Dysfunction
Mostrando 13-24 de 205 artigos, teses e dissertações.
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13. Amburana cearensis seed extracts protect PC-12 cells against toxicity induced by glutamate
ABSTRACT Amburana cearensis (Allemão) A.C. Sm., Fabaceae, has been widely studied for its medicinal activities. Many neurodegenerative disorders are caused by oxidative stress, mitochondrial dysfunction, excitotoxicity induced by glutamate and ultimately cell death. This study describes the chemical profile of the ethanolic, hexane, dichloromethane, and eth
Rev. bras. farmacogn.. Publicado em: 2017-04
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14. Cytotoxic activity of Androctonus australis hector venom and its toxic fractions on human lung cancer cell line
Abstract Background: Several studies have showed that animal venoms are a source of bioactive compounds that may inhibit the growth of cancer cells, which makes them useful agents for therapeutic applications. Recently, it was established that venom toxins from scorpions induced cytotoxic, antiproliferative and apoptogenic effects on cancer cells. Therefore
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 01/12/2016
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15. Protective Effects of Edaravone against Methamphetamine-Induced cardiotoxicity
ABSTRACT Methamphetamine (METH) is widely abused in worldwide. METH use could damage the dopaminergic system and induce cardiotoxicity via oxidative stress and mitochondrial dysfunction. Edaravone, a sedative-hypnotic agent, is known for it's antioxidant properties. In this study we used edaravone for attenuating of METH-induced cardiotoxicity in rats. The g
Braz. arch. biol. technol.. Publicado em: 28/07/2016
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16. Propofol inhibits burn injury-induced hyperpermeability through an apoptotic signal pathway in microvascular endothelial cells
Recent studies have revealed that an intrinsic apoptotic signaling cascade is involved in vascular hyperpermeability and endothelial barrier dysfunction. Propofol (2,6-diisopropylphenol) has also been reported to inhibit apoptotic signaling by regulating mitochondrial permeability transition pore (mPTP) opening and caspase-3 activation. Here, we investigated
Braz J Med Biol Res. Publicado em: 06/03/2015
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17. Factors associated with inspiratory muscle weakness in patients with HIV-1
Background:the impact of human immunodeficiency virus type 1 (HIV-1) on lung function is well known and associated with a reduction in pulmonary ventilation. Moreover, the use of highly active antiretroviral therapy has been associated with mitochondrial dysfunction and decreased muscle strength. However, there is scarce information about the factors associ
Braz J Infect Dis. Publicado em: 2015-02
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18. Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders
Introduction: Mitochondrial dysfunction has been postulated to participate in the development of many neuropsychiatric disorders, but there is no consensus as to its role. The aim of this paper is to review recent studies and to outline the current understanding of the association between mitochondrial dysfunction and psychiatric disorders. Methodology: W
Rev. Bras. Psiquiatr.. Publicado em: 15/04/2014
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19. Pathophysiology of bacterial infection of the central nervous system and its putative role in the pathogenesis of behavioral changes
Invasion of the central nervous system (CNS) by microorganisms is a severe and frequently fatal event during the course of many infectious diseases. It may lead to deafness, blindness, cerebral palsy, hydrocephalus, cognitive impairment or permanent neurological dysfunction in survivors. Pathogens can cross the blood-brain barrier by transcellular migration,
Rev. Bras. Psiquiatr.. Publicado em: 2013-03
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20. EFEITOS DE COMPOSTOS ORGÂNICOS DE SELÊNIO FRENTE À TOXICIDADE INDUZIDA POR GLUTAMATO E METILMERCÚRIO / EFFECTS OF ORGANOSELENIUM COMPOUNDS AGAINST THE TOXICITY INDUCED BY GLUTAMATE OR METHYLMERCURY
Os compostos orgânicos de selênio têm sido propostos como potenciais agentes farmacológicos para o tratamento de patologias associadas ao estresse oxidativo. Em particular, o disseleneto de difenila e o ebselen têm sido demonstrados como potentes agentes antioxidantes em uma variedade de modelos experimentais. Dessa forma, os objetivos do presente estud
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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21. Unexplained Male infertility: diagnosis and Management
Unexplained male infertility is a diagnosis reserved for men in whom routine semen analyses results are within normal values and physical as well as endocrine abnormalities were ruled out. In addition to erectile problems and coital factors, immunologic causes and sperm dysfunction may contribute to such condition. New etiologies of unexplained male infertil
Int. braz j urol.. Publicado em: 2012-10
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22. Alteraciones morfológicas en las mitocondrias en la piel de enfermos con esclerosis lateral amiotrófica esporádica
OBJECTIVES: Mitochondrial dysfunction has been reported in the central nervous system, hepatocytes and peripheral blood lymphocytes from patients with sporadic amyotrophic lateral sclerosis (SALS). However, the status of skin mitochondria has not been reported, in spite of the fact that SALS patients present skin abnormalities. The objective of the present s
Arquivos de Neuro-Psiquiatria. Publicado em: 2012-01
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23. Estudo da bioenergética mitocondrial de cardiomiócitos de camundongos obesos / Study of mitochondrial bioenergetics of cardiomyocytes of obese mice
A obesidade é uma doença crônica, resultante do excesso de gordura no organismo. O aumento da obesidade no mundo, tem se revelado como um dos fenômenos clínicos e epidemiológicos da atualidade. Estudos populacionais e em modelos animais demonstram que a origem da epidemia da obesidade está relacionada a fatores genéticos, modificações de hábitos n
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/06/2011
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24. Protective effects of organoselenium compounds against methylmercury-induced oxidative stress in mouse brain mitochondrial-enriched fractions
We evaluated the potential neuroprotective effect of 1-100 µM of four organoselenium compounds: diphenyl diselenide, 3’3-ditri-fluoromethyldiphenyl diselenide, p-methoxy-diphenyl diselenide, and p-chloro-diphenyl diselenide, against methylmercury-induced mitochondrial dysfunction and oxidative stress in mitochondrial-enriched fractions from adult Swiss mo
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-11