Mismatch Distribution
Mostrando 13-24 de 43 artigos, teses e dissertações.
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13. The presence of proteins hMLH1 and hMSH6 of DNA mismatch repair system in actinic cheilitis and squamous cell carcinoma of the lip / "A presença das proteínas hMLH1 e hMSH6 do sistema de reparo do mau pareamento do DNA em queilites actínicas e carcinomas epidermóides de lábio"
Actinic cheilitis (AC) results from chronic and excessive exposure of the lips to the ultraviolet radiation in sunlight. AC is recognized as a potentially malignant condition and it is estimated that 10% to 20% will become lip squamous cell carcinoma (LSCC). It has been suggested that virtually every LSCC was initially AC. It is well known that solar radiati
Publicado em: 2006
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14. Demographic history of wood stork (Mycteria americana) Brazilian Pantanal colonies revealed by mitochondrial DNA analysis
We used mitochondrial DNA (mtDNA) sequences to investigate the demographic history of the wood stork (Mycteria americana) populations in the Brazilian Pantanal. Sequences of 390/460 bp fragment of the mtDNA control region were analyzed in 62 wood stork specimens from 8 colonies using neutrality tests, phylogeographic, and coalescent analyses. Population expa
Genetics and Molecular Biology. Publicado em: 2006
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15. Analysis of population genetic structure of Prochilodus lineatus (Teleostei, Characiformes, Prochilodontidae) in the Rio Grande basin, São Paulo, Brazil / Análise da estrutura genética populacional do curimbatá (Prochilodus lineatus, Characiformes: Prochilodontidae) na região da bacia do Rio Grande, SP.
Prochilodus lineatus has a commercial importance in the Brazilian freshwater fishing, especially in the Rio Grande basin. Several studies have been done with P. lineatus in this area, including those delimiting populations. Since then, the Rio Grande basin has been changed due to environmental impacts caused by construction of several dams. The most expressi
Publicado em: 2006
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16. Genealogy, distribution and history of NADH4 haplotypes in Aedes (Stegomyia) aegypti (DIPTERA: CULICIDAE) populations from Brazil. / Genealogia, distribuição e história de haplótipos do gene mitocondrial NADH 4 em populações do Aedes (Stegomyia) aegypti (Diptera: Culicidae) no Brasil
Knowledge about intrapopulacional variation of biological vectors is critical for understanding the dynamics of the transmission of an infectious agent. The major objective of the present study is to characterize the variability of a gene fragment, which codes for the subunit 4 of the mitochondrial gene of the Nicotinamide Adenine Dinucleotide Dehydrogenase
Publicado em: 2005
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17. Estudo dos polimorfismos dos sistemas de aloantigenos plaquetarios humanos (HPA) em doenças hemorragicas e tromboticas
Human platelet alloantigens (HP A) are polymorphic sequencies of the platelet membrane glycoproteins, which are associated to immune platelet disorders, such as neonatal alloimmune thrombocytopenia (NAIT), post-transfusion purpura (PTP), platelet transfusion reftactoriness and may be to related to occlusive vascular disease. Several distinct biallelic system
Publicado em: 2000
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18. Analysis of spontaneous base substitutions generated in mismatch-repair-deficient strains of Escherichia coli.
We used the lacI system of Escherichia coli to examine the distribution of base substitution mutations occurring spontaneously in different mismatch-repair-deficient strains. The examination of almost 1,200 nonsense mutations generated in strains carrying the mutS, mutH, and mutU alleles confirmed that transitions are highly favored over transversions. The d
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19. Reduction of mismatch of global ventilation and perfusion on exercise is related to exercise capacity in chronic heart failure.
BACKGROUND--The inability to match lung perfusion to ventilation because of a reduced cardiac output on exercise contributes to reduced exercise capacity in chronic heart failure. OBJECTIVE--To quantify ventilation to perfusion matching at rest and at peak exercise in patients with chronic heart failure and relate this to haemodynamic and ventilatory variabl
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20. Peptide Nanopores and Lipid Bilayers: Interactions by Coarse-Grained Molecular-Dynamics Simulations
A set of 49 protein nanopore-lipid bilayer systems was explored by means of coarse-grained molecular-dynamics simulations to study the interactions between nanopores and the lipid bilayers in which they are embedded. The seven nanopore species investigated represent the two main structural classes of membrane proteins (α-helical and β-barrel), and the seve
The Biophysical Society.
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21. Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.
To investigate the mechanisms of spontaneous mutation in the Escherichia coli mutD5 mutator strain, 502 mutations generated in this strain in the N-terminal part of the lacI gene were sequenced (i-d mutations). Since the mutator strength of this strain depends on the medium in which it grows, mutations were analyzed in both minimal medium (moderate mutator a
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22. Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2
The Pms2 gene has been implicated in hereditary colon cancer and is one of several mammalian homologs of the Escherichia coli mutL DNA mismatch repair gene. To determine the effect of Pms2 inactivation on genomic integrity in vivo, hybrid transgenic mice were constructed that carry targeted disruptions at the Pms2 loci along with a chromosomally integrated m
The National Academy of Sciences of the USA.
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23. Characterization of genetic variation and 3'-azido-3'-deoxythymidine- resistance mutations of human immunodeficiency virus by the RNase A mismatch cleavage method.
The RNase A mismatch cleavage method has been applied to the characterization of natural genetic variation of human immunodeficiency virus (HIV) from different geographical areas. The approach provides a rapid and simple assay for the analysis of differences in closely related viral isolates and allows the establishment of phylogenetic relationships between
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24. Repair of Heteroduplex DNA in Xenopus Laevis Oocytes
We have hypothesized that the inheritance of heteroallelic markers during recombination of homologous DNAs in Xenopus oocytes is determined by resolution of a heteroduplex intermediate containing multiple single-base mismatches. To test this idea, we prepared synthetic heteroduplexes carrying 8 separate mispairs in vitro and injected them into oocyte nuclei.