Minimum Inhibitory Concentration
Mostrando 13-24 de 549 artigos, teses e dissertações.
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13. New Diesters Derived from Piperine: in silico Study and Evaluation of Their Antimicrobial Potential
Piperine, previously extracted from black pepper (Piper nigrum L.), was used as a precursor for the synthesis of twelve new diester derivatives. The final products were obtained through the bimolecular nucleophilic substitution reaction (SN2) of the alkyl 2-chloroacetates and the salt of piperic acid, obtained from the basic hydrolysis of piperine. The compo
J. Braz. Chem. Soc.. Publicado em: 2020-08
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14. Design, Synthesis and Antitubercular Activity of Novel Isoniazid-Cyclic-Amine-Azachalcones Hybrids
In this work, it is described the design of twenty-four heterocyclic amine-azachalcones compounds through molecular hybridization of chalcone scaffold and fragments of isoniazid, fluoroquinolones, and linezolid with antituberculosis potential. The new compounds were synthesized via Claisen-Schmidt condensation, providing yields of 36-95%. Fifteen compounds s
J. Braz. Chem. Soc.. Publicado em: 2020-06
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15. Synthesis, in silico Study and Antimicrobial Evaluation of New Diesters Derived from Phthaloylglycine
New diesters derived from phthaloylglycine (7a-7i) were synthesized and their structures characterized by infrared, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. The compounds were evaluated in an in silico study, which demonstrated positive features indicating a possible drug candidate. The diesters showed antifungal activity ranging from modera
J. Braz. Chem. Soc.. Publicado em: 2020-05
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16. Ultrasound-Promoted Synthesis, Structural Characterization and in vitro Antimicrobial Activity of New 5-Aryl-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboximidamides
This work aims the synthesis of amidino pyrazolines by the cyclocondensation reaction between 3-(hetero)aryl-1-(2-hydroxyphenyl)enones and aminoguanidine hydrochloride under sonochemical conditions. Thirteen new compounds were synthesized in 15-83% of yield after sonication for 30 min without purification by chromatography. Furthermore, antimicrobial activit
J. Braz. Chem. Soc.. Publicado em: 2020-04
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17. Synergic effect of simvastatin in combination with amphotericin B against environmental strains of Cryptococcus neoformans from northeastern Brazil: a prospective experimental study
BACKGROUND: Statins are used as cholesterol-lowering drugs and may also have direct antimicrobial effects. OBJECTIVE: To evaluate synergic interactions between simvastatin and both amphotericin B and fluconazole, against environmental strains of Cryptococcus neoformans isolated from captive birds’ droppings. DESIGNAND SETTING: Experimental study cond
Sao Paulo Med. J.. Publicado em: 2020-02
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18. Potential of thyme essential oil on arugula sanitization
RESUMO Óleos essenciais de espécies vegetais são fontes alternativas importantes de compostos antimicrobianos no combate a patógenos de importância alimentar. O presente estudo buscou avaliar a atividade antimicrobiana in vitro do óleo essencial de tomilho (Thymus vulgaris), e aplicá-lo na sanitização de rúcula (Eruca sativa) minimamente processada
Ciênc. agrotec.. Publicado em: 20/01/2020
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19. Anti-Biofilm and Hemolytic Effects of Cymbopogon citratus (Dc) Stapf Essential Oil
Abstract Objective: To perform chemical analysis and to evaluate the anti-biofilm and hemolytic effect of the essential oil of Cymbopogon citratus. Material and Methods: Gaseous chromatography coupled to mass spectrometer was performed for chemical characterization of the essential oil. To verify the antimicrobial action, the Minimum Inhibitory Concentrati
Pesqui. Bras. Odontopediatria Clín. Integr.. Publicado em: 13/01/2020
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20. Anti-Helicobacter pylori and Anti-inflammatory Properties of Eugenia uniflora L.
Abstract Helicobacter pylori is a bacterium that reaches half of the world population and it’s recognized as the main cause of chronic gastritis and peptic ulcer. In this study, we evaluated the anti-H. pylori, antioxidant and immunomodulatory activities of the methanolic (MeOH) extract of Eugenia uniflora leaves and chemical profile. Anti-H. pylori activi
Braz. arch. biol. technol.. Publicado em: 20/12/2019
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21. Acinetobacter baumannii infections in Amazon Region driven by extensively drug resistant international clones, 2016-2018
BACKGROUND Acinetobacter baumannii is a leading cause of nosocomial infections. This species is characterised by the presence of pandemic lineages (International Clones) that present a broad antimicrobial resistance profile. OBJECTIVE To perform the molecular epidemiology of carbapenem-resistant A. baumannii from a clinical setting in the Amazon Basin, an
Mem. Inst. Oswaldo Cruz. Publicado em: 25/11/2019
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22. Antimicrobial susceptibility and minimal inhibitory concentration of bacteria isolated from the eyes of dogs with keratoconjunctivitis sicca
RESUMO: O objetivo deste estudo foi avaliar o perfil de susceptibilidade antimicrobiana de bactérias isoladas de olhos de cães com ceratoconjuntivite seca (CCS). Foram avaliados 65 cães com diagnóstico de CCS e 30 cães saudáveis (Grupo Controle). Depois do diagnosticado de CCS, suabes conjuntivais foram coletados. Exames microbiológicos foram realizad
Pesq. Vet. Bras.. Publicado em: 04/11/2019
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23. Detection of efflux pump CmeABC in enrofloxacin resistant Campylobacter spp. strains isolated from broiler chickens (Gallus gallus domesticus) in the state of Rio de Janeiro, Brazil
RESUMO: As aves são os principais reservatórios de Campylobacter spp., importante patógeno de origem alimentar e a carne de frango e produtos derivados são os principais veículos desse microrganismo. O aumento de cepas de Campylobacter spp. resistentes às fluorquinolonas, uma classe antimicrobiana frequentemente empregada na avicultura e na medicina hu
Pesq. Vet. Bras.. Publicado em: 04/11/2019
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24. Inhibition and Eradication Effect of Javanese turmeric (Curcuma xanthorrhiza Roxb.) Extract Against Mature Phase Biofilm of Candida albicans
Abstract Objective: To analyze the potency of Javanese turmeric extract in inhibiting and eradicating the mature phase of C. albicans biofilm. Material and Methods: C. albicans ATCC 10231 was cultured in Sabouraud Dextrose Broth on a 96-well plate and was incubated at 37ºC. To analyze its inhibitory effect, C. albicans cultures were incubated for 1.5 hour
Pesqui. Bras. Odontopediatria Clín. Integr.. Publicado em: 31/10/2019