Miconazole
Mostrando 25-36 de 167 artigos, teses e dissertações.
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25. Therapeutic Failures with Miconazole
A retrospective review of therapeutic failures of miconazole in three patients is presented. Miconazole, a new imidazole derivative, is a broad-spectrum antifungal agent purportedly effective topically, orally, and parenterally against a number of species of fungi. Three patients with the following culturally proven deep fungal infections were treated with m
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26. Mechanism of Action of Miconazole: Labilization of Rat Liver Lysosomes In Vitro by Miconazole
Miconazole, a potent antifungal agent, labilizes rat liver lysosomes. Its labilizing effect is followed by measuring the release of lysosomal hydrolases, namely, acid phosphatase, β-glucuronidase, and arylsulfatase A. The effect of miconazole is concentration dependent in the range of 10−5 to 1.2 × 10−4 M. However, at higher concentrations, miconazole
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27. Membrane Rafts Are Involved in Intracellular Miconazole Accumulation in Yeast Cells*
Azoles inhibit ergosterol biosynthesis, resulting in ergosterol depletion and accumulation of toxic 14α-methylated sterols in membranes of susceptible yeast. We demonstrated previously that miconazole induces actin cytoskeleton stabilization in Saccharomyces cerevisiae prior to induction of reactive oxygen species, pointing to an ancillary mode of action. U
American Society for Biochemistry and Molecular Biology.
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28. Growth phase in relation to ketoconazole and miconazole susceptibilities of Candida albicans.
The antifungal imidazoles miconazole and ketoconazole inhibit synthesis of essential cell membrane components. Furthermore, miconazole can exert direct physicochemical cell membrane damage at relatively high levels, but ketoconazole cannot. Experiments were designed to explain our previous observation that concentrations of miconazole capable of causing dire
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29. Miconazole and amphotericin B alter polymorphonuclear leukocyte functions and membrane fluidity in similar fashions.
The influence of miconazole on polymorphonuclear leukocytes (PMN) was investigated and compared with that of amphotericin B (AmB). Human PMN were preincubated in vitro with miconazole or AmB at therapeutically attainable concentrations in plasma, and their chemotactic functions were assessed with the synthetic chemotactic peptide N-formylmethionyl-leucyl-phe
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30. Endogenous Reactive Oxygen Species Is an Important Mediator of Miconazole Antifungal Effect
We investigated the significance of endogenous reactive oxygen species (ROS) produced by fungi treated with miconazole. ROS production in Candida albicans was measured by a real-time fluorogenic assay. The level of ROS production was increased by miconazole at the MIC (0.125 μg/ml) and was enhanced further in a dose-dependent manner, with a fourfold increas
American Society for Microbiology.
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31. Comparison of miconazole-coated tampons with clotrimazole vaginal tablets in the treatment of vaginal candidosis.
The effectiveness and acceptability of miconazole-coated tampons were compared with those clotrimazole vaginal tablets in the treatment of vaginal candidosis in 100 women. Both treatments were highly effective in reducing the signs and symptoms of infection; 95% of the group treated with miconazole had negative culture results for Candida species immediately
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32. Susceptibility of Candida albicans to Miconazole
A total of 439 clinical isolates of Candida albicans were tested for susceptibility to miconazole by the agar dilution technique. When tests were read at 48 and 24 h, 56 and 84%, respectively, of the strains were completely inhibited by 4.0 μg of miconazole per ml, the estimated upper limit of probable clinical susceptibility.
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33. Cytochemical and Biochemical Studies of Yeasts After In Vitro Exposure to Miconazole
Yeast cells exposed to different doses of the antimycotic agent miconazole revealed important cytochemical changes in the topographic distribution of the phosphatases. A strong effect was observed on the behavior of oxidative and peroxidative enzymes. Decreased cytochrome c oxidase and peroxidase activity and increased catalase activity were seen after treat
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34. In vivo pharmacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum.
A direct study evaluating whether differential drug uptake of topical 2% miconazole and 2% ketoconazole from cream formulations into human stratum corneum correlated with differential pharmacological activity against Candida albicans was investigated in healthy human subjects. A single 24-h topical dose of 2% ketoconazole cream or 2% miconazole cream was app
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35. In Vitro Activities of Ketoconazole, Econazole, Miconazole, and Melaleuca alternifolia (Tea Tree) Oil against Malassezia Species
The in vitro activities of ketoconazole, econazole, miconazole, and tea tree oil against 54 Malassezia isolates were determined by agar and broth dilution methods. Ketoconazole was more active than both econazole and miconazole, which showed very similar activities. M. furfur was the least susceptible species. M. sympodialis, M. slooffiae, M. globosa, and M.
American Society for Microbiology.
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36. Reversible Thrombocytosis and Anemia Due to Miconazole Therapy
Miconazole was administered intravenously in six consecutive patients with, active coccidioidal infection. Such treatment was associated with progressive anemia and thrombocytosis. The hematological abnormalities appeared to be dose related and potentially reversible. Bone marrow studies demonstrated erythroid hypoplasia and increased or active platelet prod