Metallo B Lactamases
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on β-lactams and polymyxins
ABSTRACT During the last 30 years there has been a dissemination of plasmid-mediated β-lactamases in Enterobacteriaceae in Brazil. Extended spectrum β-lactamases (ESBL) are widely disseminated in the hospital setting and are detected in a lower frequency in the community setting. Cefotaximases are the most frequently detected ESBL type and Klebsiella pneum
Braz. J. Microbiol.. Publicado em: 2016-12
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2. Clinical and microbiological characteristics of OXA-23- and OXA-143-producing Acinetobacter baumannii in ICU patients at a teaching hospital, Brazil
ABSTRACT Background: Carbapenem-resistant Acinetobacter baumannii (CRAb) is an important cause of nosocomial infections especially in intensive care units. This study aimed to assess clinical aspects and the genetic background of CRAb among ICU patients at a Brazilian teaching hospital. Methods: 56 critically ill patients colonized or infected by CRAb, dur
Braz J Infect Dis. Publicado em: 2016-12
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3. Metallo-β-lactamase-production in meropenem-susceptible Pseudomonas aeruginosa isolates: risk for silent spread
The aim of this study was to characterize two metallo-β-lactamases (MBLs)-producing Pseudomonas aeruginosa clinical isolates showing meropenem susceptibility. Antimicrobial susceptibility was assessed by automated testing and Clinical and Laboratory Standards Institute agar dilution method. MBL production was investigated by phenotypic tests. Molecular typi
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-09
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4. Ocorrência de cepas de Pseudomonas aeroginosa multirresistentes produtoras de metalo-beta-lactamase bla SPM-1 em amosytras clinicas = Occurence of multiresistant strains of Pseudomonas aeroginosa producing metallo-beta-lactamase bla SPM-1 in clinical samples / Occurence of multiresistant strains of Pseudomonas aeroginosa producing metallo-beta-lactamase bla SPM-1 in clinical samples
Este estudo avaliou a ocorrência de genes para metalo b-lactamases em isolados clínicos de Pseudomonas aeruginosa do Hospital São Vicente de Paulo, RS. Os genes foram pesquisados por PCR e o perfil de susceptibilidade foi avaliado por disco-difusão. Foram analisadas 46 cepas, sendo que cinco apresentaram o gene blaSPM-1.
Publicado em: 2010
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5. Ocurrence of bla spm-1 and bla imp-1 genes of metallo-B-lactamases in clinical isolates of pseudomonas aeruginosa from three universitary hospitals in the city of Porto Alegre, Brazil
We described the ocurrence of metallo-β-lactamases (MBL) genes blaSPM-1 and blaIMP-1 in clinical isolates of Pseudomonas aeruginosa resistant to imipenem and/or ceftazidime obtained from three universitary hospitals in the city of Porto Alegre, Brazil. The MBL production was screened by phenotypic test and the genes were detected by PCR.
Publicado em: 2010
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6. Reappraisal of pseudomonas aeruginosa hospital-acquired pneumonia mortality in the era of metallo-B-lactamase-mediated multidrug resistance : a prospective observational study
Introduction Hospital-acquired pneumonia (HAP) due to Pseudomonas aeruginosa is associated with high mortality rates. The metallo-β-lactamases (MBLs) are emerging enzymes that hydrolyze virtually all β-lactams. We aimed to assess P. aeruginosa HAP mortality in a setting of high-rate MBL production Methods A prospective cohort study was performed at two ter
Publicado em: 2010
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7. Metallo-b-lactamases detection among Pseudomonas aeruginosa isolated from bloodstream infections at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo / Detecção de metalo-lactamases em cepas de Pseudomonas aeruginosa isoladas de infecções sistêmicas no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
INTRODUÇÃO: Cepas de Pseudomonas aeruginosa (PA) produtoras de Metalo-b- lactamase (MBL) tem sido reportadas como sendo uma importante causa de infecções nosocomiais assim como um grande problema terapêutico mundial. No complexo HC-FMUSP, o maior hospital universitário do Brasil, a prevalência de PA resistente aos carbapenêmicos também se apresenta
Publicado em: 2009
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8. Pneumonia Hospitalar causada por Pseudomonas aeruginosa resistente a carbapenem : fatores de risco e impacto do tratamento e da presença da metalo-beta-lactamase SPM-1 na evolução clínica / Nosocomial Pneumonia due to carbapenem-resistant Pseudomonas aeruginosa: risk factors and impact of treatment and presence of metallo-beta-lactamase SPM-1 on clinical outcome
Objetivo: O estudo procurou determinar os fatores de risco independentes para o surgimento de pneumonia hospitalar por Pseudomonas aeruginosa resistente a carbapenem em uma UTI clinico-cirurgica. Foram tambem estudados os fatores relacionados a evolucao desfavoravel nesses episodios de pneumonia nosocomial tratados com polimixina B e os fatores de risco e ev
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/06/2008
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9. IDENTIFICATION OF METALLO-β-LACTAMASES IN NONFERMENTATIVE GRAM NEGATIVES BACILLI ISOLATED IN UNIVERSITY HOSPITAL OF SANTA MARIA / IDENTIFICAÇÃO DE METALO-β-LACTAMASES EM BACILOS GRAM-NEGATIVOS NÃO FERMENTADORES ISOLADOS NO HOSPITAL UNIVERSITÁRIO DE SANTA MARIA
Nos últimos anos, o isolamento de bactérias produtoras de β-lactamases tem causado preocupação em todo o mundo, devido ao fato dessas enzimas hidrolisarem o anel β- lactâmico dos principais antimicrobianos utilizados na clínica. Este trabalho teve por objetivo avaliar a prevalência de metalo-β-lactamases (MbL) em isolados de Pseudomonas
Publicado em: 2008
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10. Kinetic analysis of extension of substrate specificity with Xanthomonas maltophilia, Aeromonas hydrophila, and Bacillus cereus metallo-beta-lactamases.
Twenty beta-lactam molecules, including penicillins, cephalosporins, penems, carbapenems, and monobactams, were investigated as potential substrates for Xanthomonas maltophilia ULA-511, Aeromonas hydrophila AE036, and Bacillus cereus 5/B/6 metallo-beta-lactamases. A detailed analysis of the kinetic parameters examined confirmed these enzymes to be broad-spec
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11. Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases
This work describes the discovery and characterization of a novel series of tricyclic natural product-derived metallo-β-lactamase inhibitors. Natural product screening of the Bacillus cereus II enzyme identified an extract from a strain of Chaetomium funicola with inhibitory activity against metallo-β-lactamases. SB236050, SB238569, and SB236049 were succe
American Society for Microbiology.
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12. Interactions of biapenem with active-site serine and metallo-beta-lactamases.
Biapenem, formerly LJC 10,627 or L-627, a carbapenem antibiotic, was studied in its interactions with 12 beta-lactamases belonging to the four molecular classes proposed by R. P. Ambler (Philos. Trans. R. Soc. Lond. Biol. Sci. 289:321-331, 1980). Kinetic parameters were determined. Biapenem was readily inactivated by metallo-beta-lactamases but behaved as a