Metabolic Networks And Pathways
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers: new evidences and old challenges
ABSTRACT Human epidermal receptors (HER1/2/3/4) belong to the class of receptor-type tyrosine kinases. After binding a ligand, dimerization, it will ocurr activation of intracellular kinases after two-dimensional and cytoplasmic tail reciprocal transphosphorylation. This transphosphorylation recruits signaling pathways such as Ras/Raf/MEK/Erk1-2, PI3-K/AKT a
Braz. J. Pharm. Sci.. Publicado em: 20/07/2017
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2. Comparisons Between Different Methods in Measuring Enzyme Similarity for Metabolic Network Alignment
Metabolic network alignments enable comparison of the similarities and differences between pathways in two metabolic networks and help to uncover the conserved sub-blocks therein. Such analysis is important in the understanding of metabolic networks and species evolution. The fundamental parts of metabolic network alignment algorithms all involve comparisons
Braz. arch. biol. technol.. Publicado em: 22/03/2016
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3. Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance
An important disease among human metabolic disorders is type 2 diabetes mellitus. This disorder involves multiple physiological defects that result from high blood glucose content and eventually lead to the onset of insulin resistance. The combination of insulin resistance, increased glucose production, and decreased insulin secretion creates a diabetic meta
Braz J Med Biol Res. Publicado em: 2013-01
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4. Feature selection and intrinsically multivariate prediction in gene regulatory networks identification / Seleção de características e predição intrinsecamente multivariada em identificação de redes de regulação gênica
Feature selection is a crucial topic in pattern recognition applications, especially in bioinformatics, where problems usually involve data with a large number of variables and small number of observations. The present work addresses feature selection aspects in the problem of gene regulatory network identification from expression profiles. Particularly, we
Publicado em: 2008
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5. Ferramentas de bioinformática para proteômica / Bioinformatics tools for proteomics
The proteomics field aims to study sets of proteins expressed in a cell or tissue, according to a specific situation, through protein identification and quantification. Though technical limitations do exist, the amount of information derived from this field increases each day. And so, there is a need for employing computational tools that enable efficient an
Publicado em: 2007
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6. Redes bayesianas para inferÃncia de redes regulatÃrias de genes
With the development of functional genomics, data on a great number of species are being obtained in huge volumes. Technologies to measure the differences of the gene expression, through mRNA concentration (microarray), have become extremely popular, and their costs are decreasing. The reconstruction of genetic networks from gene expression data to study the
Publicado em: 2005
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7. Metabolic control analysis: biological applications and insights
Metabolic control analysis provides a robust mathematical and theoretical framework for describing metabolic and signaling pathways and networks, and for quantifying the controls over these processes. Its application has already shed light on some of the principles underlying the regulation of metabolic pathways, and it is well suited to the analysis of the
BioMed Central.
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8. Extreme Pathway Lengths and Reaction Participation in Genome-Scale Metabolic Networks
Extreme pathways are a unique and minimal set of vectors that completely characterize the steady-state capabilities of genome-scale metabolic networks. A framework is provided to mathematically characterize extreme pathway length and to study how individual reactions participate in the extreme pathway structure of a network. The length of an extreme pathway
Cold Spring Harbor Laboratory Press.
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9. Pathway Processor: A Tool for Integrating Whole-Genome Expression Results into Metabolic Networks
We have developed a new tool to visualize expression data on metabolic pathways and to evaluate which metabolic pathways are most affected by transcriptional changes in whole-genome expression experiments. Using the Fisher Exact Test, the method scores biochemical pathways according to the probability that as many or more genes in a pathway would be signific
Cold Spring Harbor Laboratory Press.
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10. Determination of Redundancy and Systems Properties of the Metabolic Network of Helicobacter pylori Using Genome-Scale Extreme Pathway Analysis
The capabilities of genome-scale metabolic networks can be described through the determination of a set of systemically independent and unique flux maps called extreme pathways. The first study of genome-scale extreme pathways for the simultaneous formation of all nonessential amino acids or ribonucleotides in Helicobacter pylori is presented. Three key resu
Cold Spring Harbor Laboratory Press.
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11. GeneNet: a database on structure and functional organisation of gene networks
The GeneNet database is designed for accumulation of information on gene networks. Original technology applied in GeneNet enables description of not only a gene network structure and functional relationships between components, but also metabolic and signal transduction pathways. Specialised software, GeneNet Viewer, automatically displays the graphical diag
Oxford University Press.
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12. KEGG: Kyoto Encyclopedia of Genes and Genomes.
Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules. The major component of KEGG is the PATHWAY database that consists of graphical diagrams of biochemical pathways including most of the known metabolic pathways and some of the known regulatory pathways.