Metabolic Flux Analysis
Mostrando 1-12 de 88 artigos, teses e dissertações.
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1. Visual FTBL Generator: Visual Generation Tool for 13C-FLUX File
Abstract 13C metabolic flux analysis (13C-MFA) has achieved increasing significance in quantitative metabolic system analysis in recent years. In 13C metabolic flux analysis, 13C-FLUX software is a major analytical tool. The software’s input script is primarily expressed in textual form without visual presentation of the structure of the entire metabolic
Braz. arch. biol. technol.. Publicado em: 25/11/2019
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2. Gene Deletion Leads to Improved Valinomycin Production by Streptomyces sp. CBMAI 2042
The genus Streptomyces represents one of the largest producers of molecules with antibiotic activity. The whole genome sequencing of the endophytic microorganism Streptomyces sp. CBMAI 2042 revealed 35 gene clusters encoding for secondary metabolism including 3 non-ribosomal peptide synthetases (NRPS) and 7 NRPS-hybrids. Combining genome mining and cultivati
J. Braz. Chem. Soc.. Publicado em: 2019-03
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3. Liver proteome of mice with different genetic susceptibilities to the effects of fluoride
ABSTRACT A/J and 129P3/J mice strains have been widely studied over the last few years because they respond quite differently to fluoride (F) exposure. 129P3/J mice are remarkably resistant to the development of dental fluorosis, despite excreting less F in urine and having higher circulating F levels. These two strains also present different characteristics
J. Appl. Oral Sci.. Publicado em: 2016-06
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4. Metabolic capabilities of Actinobacillus succinogenes for succinic acid production
Attention has been focused on microbial succinic acid production as an alternative for conventional chemical synthesis that is associated with environmental pollution. A metabolic model for Actinobacillus succinogenes 130Z was developed with a mixture of glucose and xylose as substrate. The metabolic fluxes during succinicate production were determined using
Braz. J. Chem. Eng.. Publicado em: 2014-12
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5. Production of biodegradable plastics using sugarcane bagasse hemicellulosic hydrolysate. / Produção de plásticos biodegradáveis utilizando hidrolisado hemicelulósico de bagaço de cana-de-açúcar.
The aim of this thesis is to produce poly3-hydroxybutyrate (P3HB) and poli-3-hidroxibutirate-co-3-hydroxyvalerate (PHB-co-3HV), biodegradable polymers, using hemicellulosic hydrolysate, rich in xylose, from sugarcane bagasse. Metabolic flux analysis in silico of xylose metabolism indicated that, though metabolism redirection is possible to increase P3HB yiel
Publicado em: 2010
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6. Análise de fluxos metabólicos para otimização da síntese do antibiótico cosmomicina por Streptomyces olindensis ICB20
A análise de fluxos metabólicos (AFM) é uma importante ferramenta de análise do metabolismo celular. O seu conhecimento é de extrema importância para entender como deve ser conduzido às condições de cultivo de um organismo, no sentido de melhorar os processos de obtenção de produtos de interesse do homem, bem como para entender como deve ser manip
Publicado em: 2010
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7. Alteration in the composition of cell wall polysaccharides in Nicotina tabacum by modulating the expression of the uxs gene, coding for UDP-D-glucuronic acid decarboxylase enzyme (EC 4.1.1.35) / Alteração da composição dos polissacarídeos da parede celular de Nicotiana tabacum, pela modulação da expressão do gene uxs que codifica a enzima UDP-D-glucuronato descarboxilase (EC 4.1.1.35)
The plant cell wall is not only an essential structure for plants, but also an extremely important raw material in human economy. The plant cell wall has diverse utilities, for example, papermaking, textile fiber, civil construction. Polysaccharides, such as cellulose, hemicelluloses and pectins, are the major components of the primary plant cell wall (appro
Publicado em: 2007
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8. Mathematical programming techniques for analysis and design of biotechnological systems. / Técnicas de programação matemática para a análise e projeto de sistemas biotecnológicos.
A complexidade de alguns sistemas biotecnológicos impossibilita seu estudo sem o uso de técnicas de programação matemática avançadas. A quantificação de fluxos metabólicos e a síntese e projeto ótimos de plantas multiproduto são problemas com esta característica, abordados na presente tese. A quantificação de fluxos metabólicos empregando bal
Publicado em: 2005
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9. Flux Coupling Analysis of Genome-Scale Metabolic Network Reconstructions
In this paper, we introduce the Flux Coupling Finder (FCF) framework for elucidating the topological and flux connectivity features of genome-scale metabolic networks. The framework is demonstrated on genome-scale metabolic reconstructions of Helicobacter pylori, Escherichia coli, and Saccharomyces cerevisiae. The analysis allows one to determine whether any
Cold Spring Harbor Laboratory Press.
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10. Flux Analysis Uncovers Key Role of Functional Redundancy in Formaldehyde Metabolism
Genome-scale analysis of predicted metabolic pathways has revealed the common occurrence of apparent redundancy for specific functional units, or metabolic modules. In many cases, mutation analysis does not resolve function, and instead, direct experimental analysis of metabolic flux under changing conditions is necessary. In order to use genome sequences to
Public Library of Science.
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11. Comparative Metabolic Flux Analysis of Lysine-Producing Corynebacterium glutamicum Cultured on Glucose or Fructose
A comprehensive approach to 13C tracer studies, labeling measurements by gas chromatography-mass spectrometry, metabolite balancing, and isotopomer modeling, was applied for comparative metabolic network analysis of lysine-producing Corynebacterium glutamicum on glucose or fructose. Significantly reduced yields of lysine and biomass and enhanced formation of
American Society for Microbiology.
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12. Fitness, Flux and Phantoms in Temporally Variable Environments
The evolutionary problem of selection in temporally variable environments is addressed by investigating a metabolic model describing the approach to steady state of a flux emanating from a simple linear pathway of unsaturated enzymes catalyzing reversible monomolecular reactions. Analysis confirms previous claims that steps having no influence on the steady