Mesothelin
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Mesothelin as a biomarker for ovarian carcinoma: a meta-analysis
O objetivo deste trabalho foi avaliar a acurácia da mesotelina como um biomarcador para o câncer de ovário. Realizou-se uma revisão sistemática quantita tiva. Uma pesquisa global nas bases de dados Medline, LILACS, SCOPUS, Embase, Cochrane Central Register of Controlled Trials, Biomed Central, e ISI Web of Science foi realizada de janeiro de 1990 a junh
An. Acad. Bras. Ciênc.. Publicado em: 31/05/2016
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2. Structural studies of the proteins Q4DV70 from Trypanosoma cruzi and mesothelin from Homo sapiens / Estudos estruturais das proteinas Q4DV70 de Trypanosoma cruzi e mesotelina de Homo sapiens
In this work we carried out studies with two proteins, Q4DV70 from Trypanosoma cruzi and mesothelin from Homo sapiens. The aim was to help the understanding of the function of these proteins which possibly are important to Chagas disease and cancer, respectively. Q4DV70 protein was annotated in T. cruzi genome as a conserved hypothetical protein. In our stud
Publicado em: 2009
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3. Mesothelin Is Not Required for Normal Mouse Development or Reproduction
Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function(s) of the protein is not known. We have analyzed the expression of the mouse mesothelin gene in different developmental stages and in various adult tissues by Northern hybridization. The 2.5-kb
American Society for Microbiology.
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4. Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas, and several other types of human cancers. Because among normal tissues, mesothelin is present only on mesothelial cells, it represents a good target for antibody-mediated delivery of cytotoxic agents. In the present study mice were immunized with an eukaryotic e
National Academy of Sciences.
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5. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.
Monoclonal antibody MAb K1 recognizes a 40-kDa glycoprotein present on the surface of mesothelial cells, mesotheliomas, and ovarian cancers. We have used MAb K1 to isolate a 2138-bp cDNA that encodes this antigen. The cDNA has an 1884-bp open reading frame encoding a 69-kDa protein. When the cDNA was transfected into COS and NIH 3T3 cells, the antigen was fo
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6. Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma
mAb OV569 was made by immunizing mice with ovarian carcinoma cells. It binds to cells from ovarian carcinomas and, to a lesser extent, to cells from certain other carcinomas whereas the binding to normal tissues is low to nondetectable. It also binds to soluble molecule(s) in culture supernatants from antigen-positive carcinomas. OV569 recognizes a protein(s
The National Academy of Sciences.
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7. Characterization of human mesothelin transcripts in ovarian and pancreatic cancer
BioMed Central.
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8. Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma
BMJ Group.
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9. Hunting for a pleural fluid test for mesothelioma: is soluble mesothelin the answer?
BMJ Group.
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10. Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells
BioMed Central.
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11. Gene Expression Patterns in Ovarian Carcinomas
We used DNA microarrays to characterize the global gene expression patterns in surface epithelial cancers of the ovary. We identified groups of genes that distinguished the clear cell subtype from other ovarian carcinomas, grade I and II from grade III serous papillary carcinomas, and ovarian from breast carcinomas. Six clear cell carcinomas were distinguish
The American Society for Cell Biology.
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12. Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22
A 3,673-bp murine cDNA predicted to encode a glycosylphosphatidylinositol-anchored protein of 1,088 amino acids was isolated during a study aimed at identifying transcripts specifically expressed in the inner ear. This inner ear-specific protein, otoancorin, shares weak homology with megakaryocyte potentiating factor/mesothelin precursor. Otoancorin is locat
The National Academy of Sciences.