Mesencephalic Cell Culture
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Toxicidade causada pela cocaína in vitro: participação da via dopaminérgica e do fator de transcrição NF-kB. / In vitro cocaine toxicity: participation of the dopaminergic pathway and the transcription factor NF-kB.
Cocaine is a drug deeply used and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newly born have been demonstrated due to the toxics effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damages is very complex and involves interactions of the drug with several neurotransmitt
Publicado em: 2008
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2. Chalcones isolated from myracrodruon urundeuva and 2-methyl-inositol isolated from Magonia glabrata protect neurons from 6-hydroxydopamine-induced oxidative injury and apoptose: study in rat mesencephalic cell cultures / Chalconas isoladas da myracrodruon urundeuva e 2-O-metilinositol isolado da magonia glabrata protegem neurônios de danos oxidativos e apoptose induzida por 6-hidroxidopamina (6-OHDA): estudo em cultura primária de células mesencefálicas de ratos
The present work evaluated the cytoprotective effect of chalcone-enriched fraction (CEF) and 2-methyl-inositol (MIT) in primary rat mesencephalic cell culture exposed to the neurotoxin 6-hydroxydopamine (6-OHDA). The CEF was obtained from Myracrodruon urundeuva, a Brazilian medicinal plant used as an antiinflamatory and wound healing agent.in female genital
Publicado em: 2005
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3. Dopaminergic neurons from embryonic mouse mesencephalon are enriched in culture through immunoreaction with monoclonal antibody to neural specific protein 4 and flow cytometry.
Dopaminergic neurons represent a rare neurotransmitter phenotype within the mammalian central nervous system. The mesencephalic dopaminergic neurons form the ascending dopaminergic pathways in mammals and are involved in motor and limbic functions. Here we report that about 30% of all developing mouse mesencephalic cells, including virtually all of the dopam
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4. In vitro-generated neural precursors participate in mammalian brain development
During embryogenesis, pluripotent stem cells segregate into daughter lineages of progressively restricted developmental potential. In vitro, this process has been mimicked by the controlled differentiation of embryonic stem cells into neural precursors. To explore the developmental potential of these cell-culture-derived precursors in vivo, we have implanted
National Academy of Sciences.
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5. Schwann-cell differentiation in clonal cultures of the neural crest, as evidenced by the anti-Schwann cell myelin protein monoclonal antibody.
In the vertebrate embryo, Schwann cells lining the peripheral nerves originate from the neural crest (NC), a structure that also gives rise to ganglion satellite cells, most of the neurons of the peripheral nervous system, melanocytes, and part of the cranial mesenchyme. We have studied the emergence of the Schwann cell lineage in vitro in clonal cultures of