Membrane Type Matrix Metalloproteinases
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Papel de TGFβ-1 na regulação da expressão de MMPs seus inibidores (TIMPs e Reck) em modelo de carcinoma mamário humano: análise funcional de RECK e sua correlação com dados clínico-patológicos / Role of TGFβ-1 as a common regulator of MMPs and their inhibitors (TIMPs e RECK) in human breast cancer cell model: functional analysis of RECK and its correlation with clinical-pathological
The metastatic disease is the main mortality cause of breast cancer patients. The metastatic process involves a complex cascade of events, including the organized breakdown of the extracellular matrix (ECM) compounds. The degradation of ECM is tightly regulated by the balance between the activities of matrix metalloproteinases (MMPs) and their inhibitors, th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/10/2011
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2. Expression of mmp-2, mmp-9 and uPAR in normal canine prostates c proliferative lesions / Expressão de mmp-2, mmp-9 e upar em próstatas caninas normais e c lesões proliferativas
Humans and dogs show dysplastic lesions in the prostate, such as prostatic intraepithelial neoplasms (PIN) and proliferative inflammatory atrophy (PIA), which are studied due to their malignance potential. The matrix metalloproteinases (MMP) are a family of proteolytic enzymes thought to play an important role in tumor invasion and metastasis in face of thei
Publicado em: 2010
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3. Avaliação temporal e espacial da expressão das metaloproteinases de matriz tipo de membrana (MT2, MT3, MT4, MT5 e MT6-MMP) durante a ossificação endocondral em camundongos / Temporal and spatial expression of membrane type-MMPs (MT2, MT3, MT4, MT5, and MT6-MMPs) during endochondral ossification in mice
As MMPs são endopeptidases zinco dependentes que, em conjunto, podem degradar todos os componentes da MEC e gerar moléculas bioativas. São as principais responsáveis pelo remodelamento tecidual durante eventos fisiológicos normais como a embriogênese e organogênese e também em eventos patológicos como a invasão tumoral nos tecidos. As pesquisas na
Publicado em: 2010
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4. Distribuição de MT1-MMP na região odontogenica de incisivos inferiores de ratos em condições funcionais de erupção normal e alterada : estudo imunohistoquimico / MT1-MMP distribuiton in the odontogenic region of lower incisors in rats with normal and altered eruption : an immunohistochemical study
Matrix metalloproteinases (MMPs) are a growing family of endopeptidases that are capable of degrading many structural components of the extracellular matrix, including collagen. MMPs on the dental follicle may be related with remodelation that occurs in this tissue during dental eruption. MT1-MMP has been considered an important membrane-type matrix metallop
Publicado em: 2008
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5. Higher expression and activity of metalloproteinases is associated with HPV presence in human cervical carcinomas cell lines / Associação entre alta expressão e atividade de metaloproteinases e presença de HPV em linhagens de carcinomas cervicais humanos
Matrix metalloproteinases (MMPs) -2, -9, and MT1-MMP are required for basement membrane degradation in cervical carcinoma. We evaluated the expression and activity of MMPs and their inhibitors RECK and TIMP-2 in three human invasive cervical carcinoma cell lines. Two HPV-16- positive cell lines (SiHa and CaSki), HPV-negative cell line (C33A) were cultured ei
Publicado em: 2006
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6. Finasteride effects on epithelium-stroma interaction in the different rat prostatic lobes / Efeito da finasterida sobre a interação epitelio-estroma nos diferentes lobos da prostata de rato
Prostate cancer cells are generally dependent on androgen stimulation mediated by the androgen receptor (AR) for growth and survival. Therefore, hormonal manipulation, such as castration and/or the use of AR antagonists, results in a regression of the cancer. However, these treatments very rarely lead to the cure of advanced disease and cancer eventually bec
Publicado em: 2006
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7. Lung tissue remodeling in the acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is characterized by diffuse alveolar damage, and evolves progressively with three phases: exsudative, fibroproliferative, and fibrotic. In the exudative phase, there are interstitial and alveolar edemas with hyaline membrane. The fibroproliferative phase is characterized by exudate organization and fibroelastogenesi
Jornal de Pneumologia. Publicado em: 2003-08
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8. Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts
Normal fibroblasts cultured as monolayers secrete matrix metalloproteinases (MMP), including gelatinase A (72-kDa type IV collagenase) as inactive zymogens. Previously we found that normal fibroblasts cultured in a type I collagen lattice (dermal equivalent) secrete active gelatinase A. Here we show that the activation of progelatinase A occurs within the ce
The National Academy of Sciences of the USA.
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9. Metalloproteinases: role in breast carcinogenesis, invasion and metastasis
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases. Their primary function is degradation of proteins in the extracellular matrix. Currently, at least 19 members of this family are known to exist. Based on substrate specificity and domain organization, the MMPs can be loosely divided into four main groups: the interstitial col
BioMed Central.
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10. Comparative study of matrix metalloproteinase expression between African American and Caucasian Women
To date there are 26 human matrix metalloproteinases (MMPs) which are classified according to their substrate specificity and structural similarities. The four major subgroups of MMPs are gelatinases, interstitial collagenases, stromelysins, and membrane-type matrix metalloproteinases (MT-MMPs). This study investigates the expression of 26 MMPs, which have b
BioMed Central.
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11. Localization of tartrate-resistant acid phosphatase (TRAP), membrane type-1 matrix metalloproteinases (MT1-MMP) and macrophages during early endochondral bone formation
Endochondral bone formation, the process by which most parts of our skeleton evolve, leads to the establishment of the diaphyseal primary (POC) and epiphyseal secondary ossification centre (SOC) in long bones. An essential event for the development of the SOC is the early generation of vascularized cartilage canals that requires the proteolytic cleavage of t
Blackwell Science Inc.
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12. Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
Matrix metalloproteinases (MMPs) are a family of multidomain enzymes involved in the physiological degradation of connective tissue, as well as in pathological states such as tumor invasion and arthritis. Apart from transcriptional regulation, MMPs are controlled by proenzyme activation and a class of specific tissue inhibitors of metalloproteinases (TIMPs)
The National Academy of Sciences.