Membrane Microdomains
Mostrando 1-12 de 134 artigos, teses e dissertações.
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1. Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review
ABSTRACT Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs and, in turn, decrease NMDA-mediated anxiety. This hypothes
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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2. Estudo de membranas eritrocitárias resistentes a detergentes da série éter de polioxietileno (Brij)
A visão atual sobre membranas biológicas abarca descrições cada vez mais complexas devido, principalmente, à descoberta de novos papéis atribuídos aos lipídios e sua heterogeneidade. Em particular a associação de esfingolipídios e colesterol, acrescida de proteínas específicas, constitui a base da formação de domínios membranares conhecidos c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2011
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3. Membrane Microdomains composition of Paracoccidioides brasiliensis and Histoplasma capsulatum: Importance on alveolar macrophage infectivity. / Composição de Microdomínios de Membrana de Paracoccidioides brasiliensis e Histoplasma capsulatum: Importância na infectividade de macrófagos alveolares
As membranas biológicas são formadas por uma mistura de várias classes de lipídeos, cujo empacotamento preferencial entre esfingolipídeos e esteróis formam junto com proteínas específicas, esta complexa organização conhecida como microdomínios de membrana. Com o intuito de verificar a presença de microdomínios de membrana em leveduras de fungos
Publicado em: 2009
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4. Caracterização de microdomínios de membrana resitentes a detergente não iônico em promastigotas de Leishmania (Viannia) braziliensis. Papel dos microdomínios na infectividade. / Characterization of non-ionic detergent resistant membrane microdomains in Leishmania (Viannia) braziliensis promastigotes. Role of these microdmains in the infectivity
Glycoconjugates present in Leishmania surface are an important class of molecules involved in parasite-macrophage interaction. The structural elucidation of Leishmania (Viannia) braziliensis promastigote glycolipids is very relevant because in this specie the glycolipids represent the major promastigote surface glycoconjugate. Six glycolipid fractions, terme
Publicado em: 2006
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5. Papel dos (glico)esfingolipídeos e proteofosfoglicanos de Leishmania (Leishmania) amazonensis na infecção de macrófagos. Caracterização de novos antígenos e isolamento de microdomínios de membranas resistentes a detergente não-iônico. / Role of (glyco)sphingolipids and proteophosphoglycans of Leishmania (Leishmania) amazonensis on macrophage infection. Characterization of novel antigens and isolation of non-ionic detergent-resistant membrane microdomains.
As leishmanioses constituem um importante problema de saúde pública no Brasil, em razão da incidência da doença associada à alta taxa de morbidade. Devido ao fato da Leishmania ser um parasita intracelular no hospedeiro vertebrado, estudos de moléculas do parasita, que atuam na interação do parasita com a célula do hospedeiro vertebrado, são de al
Publicado em: 2006
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6. Organization of the Vesicular Stomatitis Virus Glycoprotein into Membrane Microdomains Occurs Independently of Intracellular Viral Components
The glycoprotein (G protein) of vesicular stomatitis virus (VSV) is primarily organized in plasma membranes of infected cells into membrane microdomains with diameters of 100 to 150 nm, with smaller amounts organized into microdomains of larger sizes. This organization has been observed in areas of the infected-cell plasma membrane that are outside of virus
American Society for Microbiology.
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7. Three Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma Membrane
The microlocalization of Ras proteins to different microdomains of the plasma membrane is critical for signaling specificity. Here we examine the complex membrane interactions of H-ras with a combination of FRAP on live cells to measure membrane affinity and electron microscopy of intact plasma membrane sheets to spatially map microdomains. We show that thre
American Society for Microbiology.
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8. Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection
HIV-1 infection triggers lateral membrane diffusion following interaction of the viral envelope with cell surface receptors. We show that these membrane changes are necessary for infection, as initial gp120–CD4 engagement leads to redistribution and clustering of membrane microdomains, enabling subsequent interaction of this complex with HIV-1 co-receptors
Oxford University Press.
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9. Sphingomyelin-enriched Microdomains at the Golgi Complex
Sphingomyelin- and cholesterol-enriched microdomains can be isolated as detergent-resistant membranes from total cell extracts (total-DRM). It is generally believed that this total-DRM represents microdomains of the plasma membrane. Here we describe the purification and detailed characterization of microdomains from Golgi membranes. These Golgi-derived
The American Society for Cell Biology.
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10. Microdomain-dependent Regulation of Lck and Fyn Protein-Tyrosine Kinases in T Lymphocyte Plasma Membranes
Src family protein-tyrosine kinases are implicated in signaling via glycosylphosphatidylinositol (GPI)-anchored receptors. Both kinds of molecules reside in opposite leaflets of the same sphingolipid-enriched microdomains in the lymphocyte plasma membrane without making direct contact. Under detergent-free conditions, we isolated a GPI-enriched plasma membra
The American Society for Cell Biology.
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11. Role of Plasma Membrane Lipid Microdomains in Respiratory Syncytial Virus Filament Formation
The fusion protein (F) of respiratory syncytial virus (RSV) is the envelope glycoprotein responsible for the characteristic cytopathology of syncytium formation. RSV has been shown to bud from selective areas of the plasma membrane as pleomorphic virions, including both filamentous and round particles. With immunofluorescent microscopy, we demonstrated evide
American Society for Microbiology.
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12. The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly
The superoxide-producing phagocyte NADPH oxidase consists of a membrane-bound flavocytochrome b558 complex, and cytosolic factors p47phox, p67phox and the small GTPase Rac, which translocate to the membrane to assemble the active complex following cell activation. We here show that insolubility of NADPH oxidase subunits in nonionic detergents TX-100, Brij-58
Nature Publishing Group.