Melanotropic Peptides
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Caracterização estrutural de peptídeos melanotrópicos e suas interações com agregados anfifílicos: um estudo por fluorescência e ressonância paramagnética eletrônica / Structural caracterization of melanotropic peptides and their interaction with amphilic aggregates: a study by fluorescence and electron spin resonance
Neste trabalho são apresentados vários estudos com o peptídeo melanotrópico catiônico alfa-MSH (hormônio estimulador de melanócito) e análogos biologicamente mais ativos. Foram utilizadas as técnicas de fluorescência estática e resolvida no tempo, e RPE (ressonância paramagnética eletrônica). Com fluorescência, foi monitorado o aminoácido Trp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/01/2002
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2. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.
Corticotropin (ACTH) and melanotropin (MSH) peptides (melanocortins) are produced not only in the pituitary but also in the brain, with highest concentrations in the arcuate nucleus of the hypothalamus and the commisural nucleus of the solitary tract. We have identified a receptor for MSH and ACTH peptides that is specifically expressed in regions of the hyp
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3. Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.
Proopiomelanocortin (POMC), the precursor for melanotropic, corticotropic, and opioid peptides such as alpha-melanocyte-stimulating hormone (alpha MSH), ACTH, and other related peptides, was originally identified as a product of the pituitary gland. However, recent evidence shows that POMC products can also be produced by nonpituitary tissues. Because kerati
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4. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides.
The significance of melanotropic hormones as physiologic regulators of cutaneous pigmentation in humans is still controversial. Until recently, no direct effect for melanotropins could be demonstrated on human melanocytes. Here we present conclusive evidence that alpha-melanotropin (alpha-melanocyte-stimulating hormone, alpha-MSH) and the related hormone cor
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5. Effects of melanotropic peptides on fetal adrenal gland.
Adrenal glands from early, mid, and late fetuses of rabbit, guinea pig, and rat, and from newborn animals of each species, were incubated for 1-4 h with and without 0.1 nM-1 microM ACTH, alpha- or beta-melanocyte-stimulating hormone (alpha MSH or beta MSH). The effects of the peptides were measured on production of glucocorticoids, and on incorporation of la